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This review compiles evidence from both human studies and animal models, highlighting the global prevalence of vitamin\u2009D deficiency, especially among high-risk groups such as pregnant women, infants, and children. The review identifies potential pathways through which early vitamin\u2009D deficiency affects glucose and lipid metabolism, including insulin resistance and lipid accumulation, and discusses the role of vitamin\u2009D in regulating metabolic pathways through mechanisms involving the vitamin\u2009D receptor (VDR). Key findings suggest that current vitamin\u2009D intake recommendations may not adequately prevent long-term metabolic disorders. Consequently, the study advocates for updating public health policies, highlighting that, in addition to maintaining a healthy lifestyle, early-life vitamin\u2009D supplementation may be a viable strategy for preventing future metabolic diseases in high-risk populations. Further research is required to refine dosage guidelines across diverse populations and life stages.<\/jats:p>","DOI":"10.1093\/nutrit\/nuag015","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:00:07Z","timestamp":1769086807000},"source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Early-Life Vitamin D Deficiency on Future Glucose and Lipid Metabolism: A Narrative Review"],"prefix":"10.1093","author":[{"given":"Jiayan","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, College of Public Health, Shanghai University of Medicine & Health Sciences , Shanghai, 201318,","place":["China"]},{"name":"Department of Public Health, Changbai Community Healthcare Center , Shanghai, 200093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyin","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, College of Public Health, Shanghai University of Medicine & Health Sciences , Shanghai, 201318,","place":["China"]},{"name":"Department of Food Hygiene and Nutrition, School of Public Health, Shanghai University of Traditional Chinese Medicine , Shanghai, 201203,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Public Health, Kangqiao Community Healthcare Center , Shanghai, 201315,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Public Health, Kangqiao Community Healthcare Center , Shanghai, 201315,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3612-8398","authenticated-orcid":false,"given":"Lixin","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food 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