{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:29:31Z","timestamp":1781155771927,"version":"3.54.1"},"reference-count":177,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vicente Lopez Program"},{"name":"Autonomous Government of Catalonia"},{"name":"Departament de Recerca i Universitats de la Generalitat de Catalunya to the Nutrition and Metabolic Health Research Group","award":["2021 SGR 00213"],"award-info":[{"award-number":["2021 SGR 00213"]}]},{"name":"Precision Nutrition, Wellness and Prevention of Metabolic Diseases","award":["2021 SGR 01556"],"award-info":[{"award-number":["2021 SGR 01556"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>With the global rise in aging populations, cognitive impairment and neurodegenerative diseases, such as Alzheimer\u2019s disease (AD), present a growing public health issue. Current pharmacological treatments primarily target symptoms rather than underlying causes, necessitating the exploration of alternative preventive strategies. Nutraceuticals have emerged as promising candidates for neuroprotection due to their ability to modulate oxidative stress, neuroinflammation, and mitochondrial function. This narrative review aimed to evaluate the neuroprotective potential of nutraceuticals and their interactions with the microbiota\u2013gut\u2013brain axis in preventing age-related cognitive decline. A comprehensive search of the scientific literature using the PubMed, Scopus, and Web of Science databases was undertaken, focusing on publications during the period 2010\u20132025. Nutraceuticals, including vitamins, omega-3 fatty acids, coenzyme Q10, polyphenols, and isothiocyanates, exhibit neuroprotective properties through antioxidant, anti-inflammatory, and mitochondrial-support mechanisms. The gut microbiota plays a crucial role in regulating the bioavailability and efficacy of these compounds. Microbiome-based interventions, such as prebiotics, probiotics, and fecal microbiota transplantation demonstrate potential in modulating neuroinflammatory responses and supporting cognitive function. Nutraceutical and microbiome-targeted interventions represent promising, low-risk strategies for preventing cognitive decline. Their ability to modulate neuroinflammation and oxidative stress underscores their potential for future clinical applications. Further large-scale studies are needed to validate their efficacy and explore personalized approaches adapted to individual microbiome profiles.<\/jats:p>","DOI":"10.1093\/nutrit\/nuag017","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:59:46Z","timestamp":1774375186000},"source":"Crossref","is-referenced-by-count":1,"title":["Nutraceuticals and the Microbiota\u2013Gut\u2013Brain Axis: A Pathway for Preventing Cognitive Decline"],"prefix":"10.1093","author":[{"given":"\u00c1ngela","family":"Castillo-Moral","sequence":"first","affiliation":[{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Unitat de Nutrici\u00f3 i Salut , Reus, 43204,","place":["Spain"]},{"name":"Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili , Tarragona 43007,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Toda-Ferran","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV) , Reus 43201,","place":["Spain"]},{"name":"Institute of Health Pere Virgili (IISPV) , Reus 43204,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f2nica","family":"Bull\u00f3","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV) , Reus 43201,","place":["Spain"]},{"name":"Institute of Health Pere Virgili (IISPV) , Reus 43204,","place":["Spain"]},{"name":"CIBER in Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute , Madrid 28029,","place":["Spain"]},{"name":"Center of Environmental, Food and Toxicological Technology\u2014TecnATox, Rovira i Virgili University , Reus 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