{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T02:01:55Z","timestamp":1780020115344,"version":"3.53.1"},"reference-count":82,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Hospitalized patients and those with medical disorders frequently present with nutritional deficits and systemic inflammation. Whether omega-3 polyunsaturated fatty acid (\u03c9-3 PUFA) supplementation improves survival in this vulnerable population is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to examine the potential association between \u03c9-3 PUFAs and all-cause mortality risk in hospitalized or medically ill patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>We searched the following databases from their inception to October 15, 2025: PubMed, Embase, The Cochrane Library, Web of Science, and the Chinese databases China Science and Technology Journal (CSTJ), Wanfang, Chinese Biomedical Literature (CBM), and China National Knowledge Infrastructure (CNKI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Randomized controlled trials comparing \u03c9-3 PUFAs with a placebo or standard therapy were included in the analysis to determine their effects on the composite endpoint of all-cause mortality in hospitalized or medically ill patients. Clinical data were extracted independently, and the quality of each study was evaluated. A quantitative synthesis was then conducted using both fixed- and random-effects models to estimate the mortality risk ratio between the intervention and control groups. The primary endpoint was all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>We performed statistical analyses using RevMan (version 5.3.3) and R (version 4.4.0) and calculated risk ratios (RRs) with 95% CIs to evaluate the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, this meta-analysis demonstrates that \u03c9-3 PUFA supplementation is associated with a significant reduction in the risks of all-cause, cardiovascular, and coronary heart disease mortality among hospitalized patients or individuals with existing medical conditions. Patients with cardiovascular disease or myocardial infarction appeared to derive a greater benefit. These findings suggest that \u03c9-3 PUFAs play a potential role as a beneficial intervention in the primary or secondary prevention of cardiovascular outcomes but do not address effects in community-dwelling healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO registration no. CRD42024620157.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuag077","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:12:19Z","timestamp":1776510739000},"source":"Crossref","is-referenced-by-count":0,"title":["Association Between \u03c9-3 Polyunsaturated Fatty Acid Supplementation and Mortality in Hospitalized Patients or Individuals With Established Diseases: A Systematic Review and Meta-analysis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3017-1310","authenticated-orcid":false,"given":"Lei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine , Taihe Hospital, Shiyan City, 442000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pianpian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shiyan Municipal Development and Reform Commission , Shiyan City, 442000, Hubei Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine , Taihe Hospital, Shiyan City, 442000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinggang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine , Taihe Hospital, Shiyan City, 442000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peimin","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine , Taihe Hospital, Shiyan City, 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