{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T21:22:46Z","timestamp":1787433766254,"version":"build-2736575974"},"reference-count":83,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Vice Chancellor for Research, Student Research Committee"},{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["04S46"],"award-info":[{"award-number":["04S46"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Overweight (OW) and obesity (OB) are prevalent chronic conditions commonly associated with abnormalities in lipid metabolism. Recent research suggests that high-quality proteins (HQPs), such as milk protein (MP), casein protein (CP), whey protein (WP), and soy protein (SP), may ameliorate lipid profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta-analysis of randomized controlled trials (RCTs) assessed the impact of HQP supplementation on the lipid profiles in overweight and obese adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>RCTs that fulfilled the inclusion criteria were identified by a comprehensive literature search in PubMed, Scopus, and the ISI Web of Science databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Data extracted included study characteristics, participant demographics, health status, sample size, intervention details (protein type, dose, and duration), cointerventions, and lipid outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>Fixed- or random-effects models were used to calculate weighted mean differences (WMDs) and 95% CIs. Thirty-two RCTs (39 intervention arms) with 1357 participants (710 intervention, 647 control) were included. Meta-analysis showed that HQP supplementation significantly reduced low-density lipoprotein cholesterol (LDL-C) (WMD, \u22123.45\u2009mg\/dL; 95% CI, \u22125.77 to \u22121.13, P\u2009=\u2009.004) and total cholesterol (TC) (WMD, \u22125.70\u2009mg\/dL; 95% CI, \u221210.20 to \u22121.20; P\u2009=\u2009.013). No significant effects were observed for triglycerides (TG) (WMD, \u22124.25\u2009mg\/dL; 95% CI, \u221210.49 to 1.99; P\u2009=\u2009.182) or high-density lipoprotein cholesterol (HDL-C) (WMD, 0.33\u2009mg\/dL; 95% CI, \u22120.82 to 1.48; P\u2009=\u2009.574).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of this study indicate that supplementation with HQPs was associated with reductions in LDL-C and TC; however, these effects were attenuated when high-risk-of-bias studies were excluded. Supplementation with HPQs did not affect TG and HDL-C. Additional trials with longer follow-up periods are necessary to confirm our results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuag107","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:35:07Z","timestamp":1782992107000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of High-Quality Protein Supplementation on Lipid and Lipoprotein Profiles in Overweight and Obese Adults: A GRADE-Assessed Systematic Review and Meta-Analysis of 32 Randomized Controlled Trials"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9448-7392","authenticated-orcid":false,"given":"Kian","family":"Khosravi","sequence":"first","affiliation":[{"name":"Student Research Committee, Ahvaz Jundishapur University of Medical Sciences , 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