{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:02:03Z","timestamp":1790258523022,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100016286","name":"Urmia University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Many studies have focused on the concept of \u201cnutrigenetics,\u201d which explores phenotypic responses to nutrition and lifestyle interventions in relation to an individual\u2019s genotype. No meta-analysis, to our knowledge, has evaluated their overall effects on health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically review and meta-analyze available clinical trials comparing the effect of genetically based personalized diet and lifestyle advice vs conventional diet and lifestyle advice on some anthropometric parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>Electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, were systematically searched from inception to March 2026 to identify relevant articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Using a data extraction sheet, 1 author extracted the data, and another researcher checked them. For the meta-analysis, quantitative data, including the sample sizes of each group and the means and SD, or their equivalents, for study outcomes, were extracted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>Effect sizes were calculated as weighted mean differences (WMDs) and corresponding 95% CIs, and analyses were conducted using the random-effects method. A total of 6175 records were identified, of which 8 were included in the meta-analysis. This meta-analysis showed that the body weight and body mass index (BMI) of participants receiving personalized lifestyle advice decreased by 0.52\u2009kg (95% CI, \u22121.04 to \u22120.003; P\u2009=\u2009.049) and 0.30\u2009kg m\u22122 (95% CI, \u22120.43 to \u22120.16; P\u2009&amp;lt;\u2009.001), respectively, compared with controls. Body fat percentage did not change significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, genetically based personalized nutrition and lifestyle advice may lead to a small but significant improvement in body weight and BMI compared with conventional advice, with no significant differences in body fat percentage. Therefore, more well-designed clinical trials are needed to confirm the effectiveness of genetically based personalized nutrition and lifestyle advice in weight management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO registration no. CRD42024609177)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuag125","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:57:49Z","timestamp":1785412669000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of Genetics-Based Personalized Nutrition and Lifestyle Advice vs Conventional Advice on Anthropometric Outcomes: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","author":[{"given":"Elham","family":"Sharifi-Zahabi","sequence":"first","affiliation":[{"name":"Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Pashaei","sequence":"additional","affiliation":[{"name":"Patient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia ,","place":["Iran"]},{"name":"Department of Internal Medicine, School of Medicine, Urmia 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