{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:54:46Z","timestamp":1791215686861,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Zinc is essential for cutaneous barrier integrity and immune regulation. Whether zinc status is associated with severity and whether zinc supplementation provides clinical benefit in inflammatory dermatoses remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To synthesize evidence on zinc status and validated severity indices in psoriasis, atopic dermatitis (AD), and seborrheic dermatitis, and to evaluate whether zinc supplementation improves clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed, ScienceDirect, SpringerLink, and Google Scholar (January 2000\u2013December 2025) were used. A hand\u2011search of references was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection<\/jats:title>\n                    <jats:p>Randomized trials and observational case\u2013control\/cross\u2011sectional studies reporting zinc indices (serum or erythrocyte) and\/or severity (Psoriasis Area and Severity Index, Scoring Atopic Dermatitis, Seborrheic Dermatitis Area and Severity Index).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Four reviewers screened\/extracted the data, including risk of bias using the Cochrane RoB 2 for randomized controlled trials (RCTs) and Joanna Briggs Institute tools for observational designs. Zinc units were harmonized to \u00b5g\/dL; biomatrices were not cross\u2011pooled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>Random\u2011effects meta\u2011analyses (restricted maximum likelihood) with Hartung\u2013Knapp adjustment were used for case\u2013control differences in serum zinc. Prespecified sensitivity analyses included leave-one-out removal and random-vs-fixed-effects model switching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen studies met the inclusion criteria. Serum zinc was lower in cases than in controls across conditions; zinc\u2013severity associations were inverse where compatible, with high heterogeneity driven by assay platform, age strata, and biomatrix. Directionality was robust across sensitivity analyses and influence diagnostics. Interventional data were limited and did not demonstrate routine clinical benefit of zinc supplementation beyond standard care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Zinc status is frequently reduced in AD, seborrheic dermatitis, and psoriasis and is often inversely related to severity. Methodological heterogeneity warrants random\u2011effects inference and cautious interpretation. Current evidence does not support routine zinc therapy; targeted correction of documented deficiency is reasonable pending assay\u2011standardized, deficiency\u2011enriched RCTs with prespecified clinical endpoints.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuag136","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:34:08Z","timestamp":1787052848000},"source":"Crossref","is-referenced-by-count":0,"title":["Zinc Status and Disease Severity in Psoriasis, Atopic Dermatitis, and Seborrheic Dermatitis: A Systematic Review and Meta\u2011analysis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9478-8183","authenticated-orcid":false,"given":"Monica Gea","family":"Novita","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Aesthetic, Universitas Hasanuddin , Makassar, 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