{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:40:54Z","timestamp":1792435254590,"version":"4.5.0"},"reference-count":139,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"the Coordination for the Improvement of Higher Education Personnel"},{"name":"the National Council for Scientific and Technological Development"},{"name":"the Piau\u00ed Research Support Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast cancer (BC) is a prevalent and heterogeneous neoplasm whose therapeutic resistance remains a major challenge. Ferroptosis, an iron-dependent form of regulated cell death that is characterized by lipid peroxidation, has emerged as a key mechanism linking iron metabolism, oxidative stress, and tumor aggressiveness. The objective for this narrative review was to summarize the principal mechanisms regulating ferroptosis in BC and discuss its potential as a therapeutic target. A literature review was conducted to investigate the mechanisms involved in ferroptosis in BC, with emphasis on iron metabolism, oxidative stress, lipid peroxidation, antioxidant defense systems, and differences in ferroptosis sensitivity among BC subtypes. The literature indicates intracellular iron accumulation increases reactive oxygen species generation and enhances the susceptibility of cancer cells to ferroptosis. This process is mainly controlled by the glutathione peroxidase 4\u2013glutathione and ferroptosis suppressor protein 1\u2013coenzyme Q10 antioxidant systems, which neutralize lipid peroxides and preserve membrane integrity. Dysregulation of these pathways contributes to redox imbalance and disease progression. Among BC subtypes, triple-negative tumors show greater sensitivity to ferroptosis due to heightened oxidative activity and reduced expression of protective enzymes, whereas luminal and Human epidermal growth factor receptor 2\u2013positive tumors exhibit increased resistance. Controlled induction of ferroptosis may help eliminate drug-resistant cells and enhance treatment efficacy, reinforcing its relevance as a central axis connecting metabolism, oxidative stress, and programmed cell death.<\/jats:p>","DOI":"10.1093\/nutrit\/nuag149","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:21:00Z","timestamp":1792434060000},"source":"Crossref","is-referenced-by-count":0,"title":["Ferroptosis in Breast Cancer: Linking Iron Metabolism, Intertumoral Heterogeneity, and Predictive Biomarkers of Clinical Response"],"prefix":"10.1093","author":[{"given":"Jheniffer da S","family":"Sousa","sequence":"first","affiliation":[{"name":"Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piau\u00ed , Teresina, PI 64049-550,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo S P","family":"Lima","sequence":"additional","affiliation":[{"name":"Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piau\u00ed , Teresina, PI 64049-550,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Shelda de O","family":"Neres","sequence":"additional","affiliation":[{"name":"Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piau\u00ed , Teresina, PI 64049-550,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irislene C","family":"Pereira","sequence":"additional","affiliation":[{"name":"Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piau\u00ed , Teresina, PI 64049-550,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorddam A","family":"Martins","sequence":"additional","affiliation":[{"name":"Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piau\u00ed , Teresina, PI 64049-550,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallyla J M","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piau\u00ed , Teresina, PI 64049-550,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca L","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piau\u00ed , Teresina, PI 64049-550,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana S","family":"Severo","sequence":"additional","affiliation":[{"name":"Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piau\u00ed , Teresina, PI 64049-550,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4325-7458","authenticated-orcid":false,"given":"Francisco Leonardo","family":"Torres-Leal","sequence":"additional","affiliation":[{"name":"Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piau\u00ed , Teresina, PI 64049-550,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"2026101914205004500_nuag149-B1","doi-asserted-by":"publisher","first-page":"6242","DOI":"10.1111\/jcmm.15261","article-title":"LncRNA HOTTIP facilitates the stemness of breast cancer via regulation of miR-148a-3p\/WNT1 pathway","volume":"24","author":"Han","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2026101914205004500_nuag149-B2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40659-017-0140-9","article-title":"Awareness and current knowledge of breast cancer","volume":"50","author":"Akram","year":"2017","journal-title":"Biol Res"},{"key":"2026101914205004500_nuag149-B3","doi-asserted-by":"publisher","first-page":"632079","DOI":"10.3389\/fphar.2020.632079","article-title":"Advanced approaches to breast cancer classification and diagnosis","volume":"11","author":"Zubair","year":"2021","journal-title":"Front Pharmacol"},{"key":"2026101914205004500_nuag149-B4","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41419-023-05972-0","article-title":"HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-\u03baB signaling pathway in breast cancer","volume":"14","author":"Liang","year":"2023","journal-title":"Cell Death Dis"},{"key":"2026101914205004500_nuag149-B5","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1056\/NEJM199307223290403","article-title":"A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer","volume":"329","author":"Hunter","year":"1993","journal-title":"N Engl J Med"},{"key":"2026101914205004500_nuag149-B6","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s40364-020-00229-w","article-title":"Novel insights on targeting ferroptosis in cancer therapy","volume":"8","author":"Zuo","year":"2020","journal-title":"Biomark Res"},{"key":"2026101914205004500_nuag149-B7","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.21577\/1984-6835.20180081","article-title":"Antineoplastic chemotherapics platinum-based under the light of evolutionary biology","volume":"10","author":"Silva","year":"2018","journal-title":"Virtual Qui"},{"key":"2026101914205004500_nuag149-B8","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41581-023-00689-x","article-title":"Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney","volume":"19","author":"Bay\u0131r","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"2026101914205004500_nuag149-B9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"2026101914205004500_nuag149-B10","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1111\/cas.14181","article-title":"Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells","volume":"110","author":"Yu","year":"2019","journal-title":"Cancer Sci"},{"key":"2026101914205004500_nuag149-B11","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12943-020-01157-x","article-title":"The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression","volume":"19","author":"Wu","year":"2020","journal-title":"Mol Cancer"},{"key":"2026101914205004500_nuag149-B12","doi-asserted-by":"publisher","first-page":"e436","DOI":"10.1038\/emm.2017.273","article-title":"Differential regulation of hepcidin in cancer and non-cancer tissues and its clinical implications","volume":"50","author":"Vela","year":"2018","journal-title":"Exp Mol Med"},{"key":"2026101914205004500_nuag149-B13","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/sj.bjc.6604510","article-title":"Resistance to chemotherapy: new treatments and novel insights into an old problem","volume":"99","author":"Raguz","year":"2008","journal-title":"Br J Cancer"},{"key":"2026101914205004500_nuag149-B14","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.ccell.2018.03.017","article-title":"Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress","volume":"33","author":"Tsoi","year":"2018","journal-title":"Cancer Cell"},{"key":"2026101914205004500_nuag149-B15","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"key":"2026101914205004500_nuag149-B16","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1631\/jzus.B2200194","article-title":"Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns","volume":"23","author":"Qu","year":"2022","journal-title":"J Zhejiang Univ Sci B"},{"key":"2026101914205004500_nuag149-B17","volume-title":"Tratado de Hematologia","author":"Zago","year":"2013"},{"key":"2026101914205004500_nuag149-B18","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.tips.2021.05.001","article-title":"Iron metabolism: pathophysiology and pharmacology","volume":"42","author":"Roemhild","year":"2021","journal-title":"Trends Pharmacol Sci"},{"key":"2026101914205004500_nuag149-B19","volume-title":"Biodisponibilidade de nutrientes","author":"Cozzolino","year":"2015","edition":"4th"},{"key":"2026101914205004500_nuag149-B20","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.bbamcr.2016.12.002","article-title":"Iron mediated toxicity and programmed cell death: a review and a re-examination of existing paradigms","volume":"1864","author":"Eid","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"2026101914205004500_nuag149-B21","doi-asserted-by":"publisher","first-page":"8412","DOI":"10.7150\/thno.59092","article-title":"Targeting iron metabolism in cancer therapy","volume":"11","author":"Morales","year":"2021","journal-title":"Theranostics"},{"key":"2026101914205004500_nuag149-B22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.canlet.2019.08.007","article-title":"Iron and lung cancer","volume":"464","author":"Kuang","year":"2019","journal-title":"Cancer Lett"},{"key":"2026101914205004500_nuag149-B23","doi-asserted-by":"publisher","first-page":"5918218","DOI":"10.1155\/2022\/5918218","article-title":"Iron metabolism and ferroptosis in peripheral nerve injury","volume":"2022","author":"Huang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"2026101914205004500_nuag149-B24","doi-asserted-by":"publisher","first-page":"590226","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2026101914205004500_nuag149-B25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat Chem Biol"},{"key":"2026101914205004500_nuag149-B26","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s10147-011-0327-y","article-title":"Serum total oxidant\/antioxidant status and trace element levels in breast cancer patients","volume":"17","author":"Feng","year":"2012","journal-title":"Int J Clin Oncol"},{"key":"2026101914205004500_nuag149-B27","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrc3495","article-title":"Iron and cancer: more ore to be mined","volume":"13","author":"Torti","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"2026101914205004500_nuag149-B28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s13238-014-0119-z","article-title":"Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities","volume":"6","author":"Zhang","year":"2015","journal-title":"Protein Cell"},{"key":"2026101914205004500_nuag149-B29","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1089\/gtmb.2016.0300","article-title":"Association of single-nucleotide polymorphism in the hepcidin promoter gene with susceptibility to extrapulmonary tuberculosis","volume":"21","author":"Liang","year":"2017","journal-title":"Genet Test Mol Biomarkers"},{"key":"2026101914205004500_nuag149-B30","doi-asserted-by":"publisher","first-page":"6493","DOI":"10.3390\/ijms22126493","article-title":"Hepcidin-ferroportin interaction controls systemic iron homeostasis","volume":"22","author":"Nemeth","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026101914205004500_nuag149-B31","doi-asserted-by":"publisher","first-page":"5157","DOI":"10.1007\/s11033-023-08433-1","article-title":"Expression of genes related to iron homeostasis in breast cancer","volume":"50","author":"Mutlu","year":"2023","journal-title":"Mol Biol Rep"},{"key":"2026101914205004500_nuag149-B32","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1016\/j.cellsig.2014.07.029","article-title":"Disordered hepcidin\u2013ferroportin signaling promotes breast cancer growth","volume":"26","author":"Zhang","year":"2014","journal-title":"Cell Signal"},{"key":"2026101914205004500_nuag149-B33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1159\/000087513","article-title":"In silico comparison of gene expression levels in ten human tumor types reveals candidate genes associated with carcinogenesis","volume":"112","author":"Chen","year":"2006","journal-title":"Cytogenet Genome Res"},{"key":"2026101914205004500_nuag149-B34","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1186\/s12885-019-5642-0","article-title":"Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis","volume":"19","author":"Chang","year":"2019","journal-title":"BMC Cancer"},{"key":"2026101914205004500_nuag149-B35","doi-asserted-by":"publisher","first-page":"963","DOI":"10.3390\/life12070963","article-title":"Iron overload and breast cancer: iron chelation as a potential therapeutic approach","volume":"12","author":"Islam","year":"2022","journal-title":"Life (Basel)"},{"key":"2026101914205004500_nuag149-B36","doi-asserted-by":"publisher","first-page":"111159","DOI":"10.1016\/j.jinorgbio.2020.111159","article-title":"Iron promotes breast cancer cell migration via IL-6\/JAK2\/STAT3 signaling pathways in a paracrine or autocrine IL-6-rich inflammatory environment","volume":"210","author":"Cheng","year":"2020","journal-title":"J Inorg Biochem"},{"key":"2026101914205004500_nuag149-B37","doi-asserted-by":"publisher","first-page":"132","DOI":"10.12873\/362alburquerqueleticia","article-title":"Serum iron, zinc and copper and nutritional status of patients with breast cancer","volume":"36","author":"De Albuquerque Ara\u00fajo","year":"2016","journal-title":"Nutr Clin Diet Hosp"},{"key":"2026101914205004500_nuag149-B38","doi-asserted-by":"publisher","first-page":"BC25","DOI":"10.7860\/JCDR\/2015\/11627.5476","article-title":"Serum levels of metal ions in female patients with breast cancer","volume":"9","author":"Pavithra","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"2026101914205004500_nuag149-B39","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.etap.2017.05.014","article-title":"Cadmium, arsenic, selenium and iron- implications for tumor progression in breast cancer","volume":"53","author":"Jablonska","year":"2017","journal-title":"Environ Toxicol Pharmacol"},{"key":"2026101914205004500_nuag149-B40","doi-asserted-by":"publisher","first-page":"114","DOI":"10.14196\/mjiri.31.114","article-title":"Comparison of hematological parameters, iron levels, and oxidative stress in women with and without breast cancer: a case-control study","volume":"31","author":"Rajizadeh","year":"2017","journal-title":"Med J Islam Repub Iran"},{"key":"2026101914205004500_nuag149-B41","doi-asserted-by":"publisher","first-page":"25","DOI":"10.18051\/UnivMed.2018.v37.25-30","article-title":"High serum iron and zinc decrease glutathione S-transferase among women with breast cancer","volume":"37","author":"Roestijawati","year":"2018","journal-title":"Univ Med"},{"key":"2026101914205004500_nuag149-B42","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"key":"2026101914205004500_nuag149-B43","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"key":"2026101914205004500_nuag149-B44","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ"},{"key":"2026101914205004500_nuag149-B45","doi-asserted-by":"publisher","first-page":"586578","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2026101914205004500_nuag149-B46","doi-asserted-by":"publisher","first-page":"101953","DOI":"10.1016\/j.redox.2021.101953","article-title":"Reactive oxygen species produced by altered tumor metabolism impacts cancer stem cell maintenance","volume":"44","author":"Tuy","year":"2021","journal-title":"Redox Biol"},{"key":"2026101914205004500_nuag149-B47","doi-asserted-by":"publisher","first-page":"4677","DOI":"10.26355\/eurrev_202207_29192","article-title":"Role of oxidative stress in angiogenesis and the therapeutic potential of antioxidants in breast cancer","volume":"26","author":"Mdkhana","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2026101914205004500_nuag149-B48","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1007\/s13277-016-4873-9","article-title":"The role of oxidative stress on breast cancer development and therapy","volume":"37","author":"Hecht","year":"2016","journal-title":"Tumour Biol"},{"key":"2026101914205004500_nuag149-B49","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.3390\/cells9122591","article-title":"Iron: an essential element of cancer metabolism","volume":"9","author":"Hsu","year":"2020","journal-title":"Cells"},{"key":"2026101914205004500_nuag149-B50","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab"},{"key":"2026101914205004500_nuag149-B51","doi-asserted-by":"publisher","first-page":"994458","DOI":"10.3389\/fnins.2022.994458","article-title":"Deep profiling of multiple ischemic lesions in a large, multi-center cohort: frequency, spatial distribution, and associations to clinical characteristics","volume":"16","author":"Bonkhoff","year":"2022","journal-title":"Front Neurosci"},{"key":"2026101914205004500_nuag149-B52","doi-asserted-by":"publisher","first-page":"e202105043","DOI":"10.1083\/jcb.202105043","article-title":"Mitochondrial regulation of ferroptosis","volume":"220","author":"Gan","year":"2021","journal-title":"J Cell Biol"},{"key":"2026101914205004500_nuag149-B53","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol"},{"key":"2026101914205004500_nuag149-B54","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13045-020-01016-8","article-title":"Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells","volume":"14","author":"Ding","year":"2021","journal-title":"J Hematol Oncol"},{"key":"2026101914205004500_nuag149-B55","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1038\/cdd.2017.149","article-title":"How do we fit ferroptosis in the family of regulated cell death?","volume":"24","author":"Fearnhead","year":"2017","journal-title":"Cell Death Differ"},{"key":"2026101914205004500_nuag149-B56","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jid.2021.06.014","article-title":"Ironing-out the details: new strategies for combining ferroptosis inhibitors with immunotherapy in melanoma","volume":"142","author":"Emmons","year":"2022","journal-title":"J Invest Dermatol"},{"key":"2026101914205004500_nuag149-B57","doi-asserted-by":"publisher","first-page":"637162","DOI":"10.3389\/fcell.2021.637162","article-title":"Characteristics and biomarkers of ferroptosis","volume":"9","author":"Chen","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026101914205004500_nuag149-B58","doi-asserted-by":"publisher","first-page":"1524711","DOI":"10.3389\/fimmu.2025.1524711","article-title":"Ferroptosis: a novel perspective on tumor immunotherapy","volume":"16","author":"Xu","year":"2025","journal-title":"Front Immunol"},{"key":"2026101914205004500_nuag149-B59","doi-asserted-by":"publisher","first-page":"1410018","DOI":"10.3389\/fimmu.2024.1410018","article-title":"Ferroptosis: mechanism, immunotherapy and role in ovarian cancer","volume":"15","author":"Guo","year":"2024","journal-title":"Front Immunol"},{"key":"2026101914205004500_nuag149-B60","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"2026101914205004500_nuag149-B61","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"2026101914205004500_nuag149-B62","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1007\/s00011-021-01495-6","article-title":"Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells-\u201cutilization\u201d of ferroptosis mechanism","volume":"70","author":"Li","year":"2021","journal-title":"Inflamm Res"},{"key":"2026101914205004500_nuag149-B63","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13045-024-01564-3","article-title":"Ferroptosis: principles and significance in health and disease","volume":"17","author":"Chen","year":"2024","journal-title":"J Hematol Oncol"},{"key":"2026101914205004500_nuag149-B64","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/cac2.12250","article-title":"Ferroptosis in cancer and cancer immunotherapy","volume":"42","author":"Zhao","year":"2022","journal-title":"Cancer Commun (Lond)"},{"key":"2026101914205004500_nuag149-B65","doi-asserted-by":"publisher","first-page":"101017","DOI":"10.1016\/j.neo.2024.101017","article-title":"Emerging role of necroptosis, pyroptosis, and ferroptosis in breast cancer: new dawn for overcoming therapy resistance","volume":"55","author":"Fu","year":"2024","journal-title":"Neoplasia"},{"key":"2026101914205004500_nuag149-B66","doi-asserted-by":"publisher","first-page":"104919","DOI":"10.1016\/j.phrs.2020.104919","article-title":"The application of ferroptosis in diseases","volume":"159","author":"Qiu","year":"2020","journal-title":"Pharmacol Res"},{"key":"2026101914205004500_nuag149-B67","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cytogfr.2025.06.007","article-title":"Ferroptosis in immune cells: implications for tumor immunity and cancer therapy","volume":"84","author":"Gao","year":"2025","journal-title":"Cytokine Growth Factor Rev"},{"key":"2026101914205004500_nuag149-B68","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s10552-013-0219-8","article-title":"Iron metabolism and risk of cancer in the Swedish AMORIS study","volume":"24","author":"Gaur","year":"2013","journal-title":"Cancer Causes Control"},{"key":"2026101914205004500_nuag149-B69","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"2026101914205004500_nuag149-B70","doi-asserted-by":"publisher","first-page":"107992","DOI":"10.1016\/j.pharmthera.2021.107992","article-title":"Emerging role of ferroptosis in breast cancer: new dawn for overcoming tumor progression","volume":"232","author":"Sui","year":"2022","journal-title":"Pharmacol Ther"},{"key":"2026101914205004500_nuag149-B71","doi-asserted-by":"publisher","first-page":"1036140","DOI":"10.3389\/fphar.2022.1036140","article-title":"Targeting ferroptosis, the Achilles\u2019 heel of breast cancer: a review","volume":"13","author":"Liu","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026101914205004500_nuag149-B72","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"2026101914205004500_nuag149-B73","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol Cancer"},{"key":"2026101914205004500_nuag149-B74","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat Chem Biol"},{"key":"2026101914205004500_nuag149-B75","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40364-020-00230-3","article-title":"Targeting ferroptosis in breast cancer","volume":"8","author":"Li","year":"2020","journal-title":"Biomark Res"},{"key":"2026101914205004500_nuag149-B76","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1038\/s44321-024-00090-6","article-title":"FADS1\/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer","volume":"16","author":"Lorito","year":"2024","journal-title":"EMBO Mol Med"},{"key":"2026101914205004500_nuag149-B77","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41419-025-07354-0","article-title":"Targeting estrogen-regulated system xc- promotes ferroptosis and endocrine sensitivity of ER+ breast cancer","volume":"16","author":"Cao","year":"2025","journal-title":"Cell Death Dis"},{"key":"2026101914205004500_nuag149-B78","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/s41419-023-06042-1","article-title":"Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer","volume":"14","author":"Park","year":"2023","journal-title":"Cell Death Dis"},{"key":"2026101914205004500_nuag149-B79","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res"},{"key":"2026101914205004500_nuag149-B80","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"2026101914205004500_nuag149-B81","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1007\/s13238-021-00841-y","article-title":"Ferroptosis, radiotherapy, and combination therapeutic strategies","volume":"12","author":"Lei","year":"2021","journal-title":"Protein Cell"},{"key":"2026101914205004500_nuag149-B82","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"2026101914205004500_nuag149-B83","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13045-022-01392-3","article-title":"Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research","volume":"15","author":"Tong","year":"2022","journal-title":"J Hematol Oncol"},{"key":"2026101914205004500_nuag149-B84","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41419-023-05930-w","article-title":"Ferroptosis as a potential target for cancer therapy","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis"},{"key":"2026101914205004500_nuag149-B85","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D\u2019Arcy","year":"2019","journal-title":"Cell Biol Int"},{"key":"2026101914205004500_nuag149-B86","doi-asserted-by":"publisher","first-page":"9703","DOI":"10.3390\/ijms25179703","article-title":"Cell death: mechanisms and potential targets in breast cancer therapy","volume":"25","author":"Qian","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026101914205004500_nuag149-B87","doi-asserted-by":"publisher","first-page":"1493188","DOI":"10.3389\/fphar.2024.1493188","article-title":"Targeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application","volume":"15","author":"Imam","year":"2025","journal-title":"Front Pharmacol"},{"key":"2026101914205004500_nuag149-B88","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.trecan.2023.02.001","article-title":"Cell death, therapeutics, and the immune response in cancer","volume":"9","author":"H\u00e4nggi","year":"2023","journal-title":"Trends Cancer"},{"key":"2026101914205004500_nuag149-B89","doi-asserted-by":"publisher","first-page":"7517","DOI":"10.3390\/ijms25147517","article-title":"Immunotherapy in breast cancer","volume":"25","author":"Dvir","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026101914205004500_nuag149-B90","doi-asserted-by":"publisher","first-page":"e2300230","DOI":"10.1002\/smtd.202300230","article-title":"Triple tumor microenvironment-responsive ferroptosis pathways induced by manganese-based imageable nanoenzymes for enhanced breast cancer theranostics","volume":"7","author":"He","year":"2023","journal-title":"Small Methods"},{"key":"2026101914205004500_nuag149-B91","doi-asserted-by":"publisher","first-page":"100913","DOI":"10.1016\/j.ctarc.2025.100913","article-title":"Ferroptosis as the new approach to cancer therapy","volume":"43","author":"Ojo","year":"2025","journal-title":"Cancer Treat Res Commun"},{"key":"2026101914205004500_nuag149-B92","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"2026101914205004500_nuag149-B93","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1158\/2159-8290.CD-19-0338","article-title":"Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11","volume":"9","author":"Lang","year":"2019","journal-title":"Cancer Discov"},{"key":"2026101914205004500_nuag149-B94","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"key":"2026101914205004500_nuag149-B95","doi-asserted-by":"publisher","first-page":"e2204514","DOI":"10.1002\/advs.202204514","article-title":"Ferroptosis signature shapes the immune profiles to enhance the response to immune checkpoint inhibitors in head and neck cancer","volume":"10","author":"Chung","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"2026101914205004500_nuag149-B96","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2018.10.426","article-title":"Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer","volume":"129","author":"Shin","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"2026101914205004500_nuag149-B97","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"2026101914205004500_nuag149-B98","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3390\/ijms26020635","article-title":"Ferroptosis inducers erastin and RSL3 enhance adriamycin and topotecan sensitivity in ABCB1\/ABCG2-expressing tumor cells","volume":"26","author":"Perera","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026101914205004500_nuag149-B99","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/s41419-021-04306-2","article-title":"Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells","volume":"12","author":"Sun","year":"2021","journal-title":"Cell Death Dis"},{"key":"2026101914205004500_nuag149-B100","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41571-026-01128-z","article-title":"Translating ferroptosis into oncology: challenges, opportunities and future directions","volume":"23","author":"Kang","year":"2026","journal-title":"Nat Rev Clin Oncol"},{"key":"2026101914205004500_nuag149-B101","doi-asserted-by":"publisher","first-page":"e14506","DOI":"10.7717\/peerj.14506","article-title":"Identification and validation of a ferroptosis-related lncRNA signature to robustly predict the prognosis, immune microenvironment, and immunotherapy efficiency in patients with clear cell renal cell carcinoma","volume":"10","author":"Ju","year":"2022","journal-title":"PeerJ"},{"key":"2026101914205004500_nuag149-B102","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s43018-023-00653-5","article-title":"Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia","volume":"5","author":"Bruedigam","year":"2024","journal-title":"Nat Cancer"},{"key":"2026101914205004500_nuag149-B103","doi-asserted-by":"publisher","first-page":"6284540","DOI":"10.1155\/2022\/6284540","article-title":"A ferroptosis-related LncRNA signature associated with prognosis, tumor immune environment, and genome instability in hepatocellular carcinoma","volume":"2022","author":"Lian","year":"2022","journal-title":"Comput Math Methods Med"},{"key":"2026101914205004500_nuag149-B104","doi-asserted-by":"publisher","first-page":"101287","DOI":"10.1016\/j.tjnut.2025.101287","article-title":"Pesco-vegetarian food components promote colonocyte ferroptosis in preclinical mouse models and a randomized crossover trial in healthy human adults","volume":"156","author":"Fan","year":"2026","journal-title":"J Nutr"},{"key":"2026101914205004500_nuag149-B105","author":"ClinicalTrials.gov"},{"key":"2026101914205004500_nuag149-B106","author":"ClinicalTrials.gov"},{"key":"2026101914205004500_nuag149-B107","author":"ClinicalTrials.gov"},{"key":"2026101914205004500_nuag149-B108","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.actbio.2023.02.015","article-title":"An iron oxyhydroxide-based nanosystem sensitizes ferroptosis by a \"three-pronged\" strategy in breast cancer stem cells","volume":"160","author":"Wu","year":"2023","journal-title":"Acta Biomater"},{"key":"2026101914205004500_nuag149-B109","doi-asserted-by":"publisher","first-page":"122395","DOI":"10.1016\/j.biomaterials.2023.122395","article-title":"Ferroptosis-enhanced chemotherapy for triple-negative breast cancer with magnetic composite nanoparticles","volume":"303","author":"Zhang","year":"2023","journal-title":"Biomaterials"},{"key":"2026101914205004500_nuag149-B110","doi-asserted-by":"publisher","first-page":"10509","DOI":"10.1021\/acsnano.3c12064","article-title":"Iron oxide nanoparticles inhibit tumor progression and suppress lung metastases in mouse models of breast cancer","volume":"18","author":"Korangath","year":"2024","journal-title":"ACS Nano"},{"key":"2026101914205004500_nuag149-B111","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.jcis.2024.02.201","article-title":"Au-Fe3O4Janus nanoparticles for imaging-guided near infrared-enhanced ferroptosis therapy in triple negative breast cancer","volume":"663","author":"Wei","year":"2024","journal-title":"J Colloid Interface Sci"},{"key":"2026101914205004500_nuag149-B112","doi-asserted-by":"publisher","first-page":"6191","DOI":"10.1021\/acs.nanolett.0c02515","article-title":"Spatiotemporally targeted nanomedicine overcomes hypoxia-induced drug resistance of tumor cells after disrupting neovasculature","volume":"20","author":"Chen","year":"2020","journal-title":"Nano Lett"},{"key":"2026101914205004500_nuag149-B113","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2015.10.019","article-title":"\u201cCombo\u201d nanomedicine: co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy","volume":"98","author":"Kemp","year":"2016","journal-title":"Adv. Drug Del. Rev"},{"key":"2026101914205004500_nuag149-B114","doi-asserted-by":"publisher","first-page":"1900730","DOI":"10.1002\/advs.201900730","article-title":"Engineering state-of-the-art plasmonic nanomaterials for SERS-based clinical liquid biopsy applications","volume":"6","author":"Wang","year":"2019","journal-title":"Adv Sci (Weinh)"},{"key":"2026101914205004500_nuag149-B115","doi-asserted-by":"publisher","first-page":"6670","DOI":"10.1039\/C9TB01490J","article-title":"Advanced liquid biopsy technologies for circulating biomarker detection","volume":"7","author":"Soda","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"2026101914205004500_nuag149-B116","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12943-017-0644-5","article-title":"Liquid biopsy: a step forward towards precision medicine in urologic malignancies","volume":"16","author":"Di Meo","year":"2017","journal-title":"Mol Cancer"},{"key":"2026101914205004500_nuag149-B117","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-022-01004-z","article-title":"ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity","volume":"7","author":"Gan","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"2026101914205004500_nuag149-B118","doi-asserted-by":"publisher","first-page":"1594419","DOI":"10.3389\/fphar.2025.1594419","article-title":"ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis","volume":"16","author":"Jiang","year":"2025","journal-title":"Front. Pharmacol"},{"key":"2026101914205004500_nuag149-B119","doi-asserted-by":"publisher","first-page":"1043344","DOI":"10.3389\/fphar.2022.1043344","article-title":"Ferritinophagy, a form of autophagic ferroptosis: new insights into cancer treatment","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Pharmacol"},{"key":"2026101914205004500_nuag149-B120","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41420-024-01938-z","article-title":"The crosstalk between exosomes and ferroptosis: a review","volume":"10","author":"Wu","year":"2024","journal-title":"Cell Death Discov"},{"key":"2026101914205004500_nuag149-B121","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13046-024-03026-7","article-title":"Liquid biopsy techniques and lung cancer: diagnosis, monitoring and evaluation","volume":"43","author":"Ren","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"2026101914205004500_nuag149-B122","doi-asserted-by":"publisher","first-page":"1331215","DOI":"10.3389\/fonc.2024.1331215","article-title":"Metabolomic biomarkers in liquid biopsy: accurate cancer diagnosis and prognosis monitoring","volume":"14","author":"Wang","year":"2024","journal-title":"Front Oncol"},{"key":"2026101914205004500_nuag149-B123","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13045-024-01531-y","article-title":"Optical nanomaterial-based detection of biomarkers in liquid biopsy","volume":"17","author":"Kim","year":"2024","journal-title":"J Hematol Oncol"},{"key":"2026101914205004500_nuag149-B124","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s12943-025-02445-0","article-title":"Advances in novel cell death mechanisms in breast cancer: intersecting perspectives on ferroptosis, cuproptosis, disulfidptosis, and pyroptosis","volume":"24","author":"Jing","year":"2025","journal-title":"Mol Cancer"},{"key":"2026101914205004500_nuag149-B125","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41419-026-08460-3","article-title":"CD36 enhances sensitivity of triple negative breast cancer cells to palmitate-induced ferroptosis","volume":"17","author":"Closset","year":"2026","journal-title":"Cell Death Dis"},{"key":"2026101914205004500_nuag149-B126","doi-asserted-by":"publisher","first-page":"111869","DOI":"10.1016\/j.cellsig.2025.111869","article-title":"Role of ferroptosis in breast cancer: molecular mechanisms and therapeutic interventions","volume":"134","author":"Wang","year":"2025","journal-title":"Cell Signal"},{"key":"2026101914205004500_nuag149-B127","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1017\/S0954422421000226","article-title":"Ferroptosis regulations by nutrient signalling","volume":"35","author":"Qi","year":"2022","journal-title":"Nutr Res Rev"},{"key":"2026101914205004500_nuag149-B128","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","article-title":"Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke","volume":"177","author":"Alim","year":"2019","journal-title":"Cell"},{"key":"2026101914205004500_nuag149-B129","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"2026101914205004500_nuag149-B130","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.chembiol.2020.03.012","article-title":"Selenium: tracing another essential element of ferroptotic cell death","volume":"27","author":"Conrad","year":"2020","journal-title":"Cell Chem Biol"},{"key":"2026101914205004500_nuag149-B131","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1002\/bab.2176","article-title":"Vitamin E at a high dose as an anti-ferroptosis drug and not just a supplement for COVID-19 treatment","volume":"69","author":"Tavakol","year":"2022","journal-title":"Biotechnol Appl Biochem"},{"key":"2026101914205004500_nuag149-B132","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026101914205004500_nuag149-B133","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3390\/cells12050804","article-title":"Polyunsaturated fatty acids drive lipid peroxidation during ferroptosis","volume":"12","author":"Mortensen","year":"2023","journal-title":"Cells"},{"key":"2026101914205004500_nuag149-B134","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/s41467-023-36630-w","article-title":"Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism","volume":"14","author":"Upadhyayula","year":"2023","journal-title":"Nat Commun"},{"key":"2026101914205004500_nuag149-B135","doi-asserted-by":"publisher","first-page":"e70042","DOI":"10.1002\/cph4.70042","article-title":"Crosstalk between microbiome and ferroptosis in diseases: from mechanism to therapy","volume":"15","author":"Ding","year":"2025","journal-title":"Compr Physiol"},{"key":"2026101914205004500_nuag149-B136","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1172\/JCI122359","article-title":"Hepatic hepcidin\/intestinal HIF-2\u03b1 axis maintains iron absorption during iron deficiency and overload","volume":"129","author":"Schwartz","year":"2019","journal-title":"J Clin Invest"},{"key":"2026101914205004500_nuag149-B137","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/sj.bjc.6604503","article-title":"High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study","volume":"99","author":"Akil","year":"2008","journal-title":"Br J Cancer"},{"key":"2026101914205004500_nuag149-B138","doi-asserted-by":"publisher","first-page":"914.2","DOI":"10.1096\/fasebj.29.1_supplement.914.2","article-title":"Relationship between intestinal microbiota and clinical characteristics of patients with early stage breast cancer","volume":"29","author":"Bard","year":"2015","journal-title":"FASEB J"},{"key":"2026101914205004500_nuag149-B139","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fonc.2020.00120","article-title":"Microbiome and breast cancer: new role for an ancient population","volume":"10","author":"Eslami-S","year":"2020","journal-title":"Front Oncol"}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/advance-article-pdf\/doi\/10.1093\/nutrit\/nuag149\/72115915\/nuag149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/advance-article-pdf\/doi\/10.1093\/nutrit\/nuag149\/72115915\/nuag149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:21:02Z","timestamp":1792434062000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/advance-article\/doi\/10.1093\/nutrit\/nuag149\/8943677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":139,"URL":"https:\/\/doi.org\/10.1093\/nutrit\/nuag149","relation":{},"ISSN":["0029-6643","1753-4887"],"issn-type":[{"value":"0029-6643","type":"print"},{"value":"1753-4887","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"article-number":"nuag149"}}