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The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12","volume":"42","author":"Schilling","year":"1953","journal-title":"J Lab Clin Med"},{"key":"key\n\t\t\t\t20180910171309_nuy026-B63","first-page":"85","article-title":"[Urinary excretion study with radioactive vitamin B 12 (Schilling test) in internal, neurologic and psychiatric diseases]","author":"Castrill\u03ccn-OberndorferSt\u00fcber","year":"1967","journal-title":"Nucl Med (Stuttgart)"},{"key":"key\n\t\t\t\t20180910171309_nuy026-B64","first-page":"300","article-title":"Schilling test of vitamin B12 absorption","volume":"1","year":"1969","journal-title":"Br Med J"},{"key":"key\n\t\t\t\t20180910171309_nuy026-B65","first-page":"2320","article-title":"[Schilling test for absorption of 57-Co-vitamin B12]","volume":"suppl)","author":"Chiba","year":"1979","journal-title":"Nihon Rinsho"},{"key":"key\n\t\t\t\t20180910171309_nuy026-B66","first-page":"77","article-title":"[The radio-vitamin B-12 resorption-urinary excreton test (Schilling test)]","volume":"17","author":"Bublitz","year":"1964","journal-title":"Rontgenpraxis."},{"key":"key\n\t\t\t\t20180910171309_nuy026-B67","first-page":"989","article-title":"Use of Schilling test in the study of intestinal absorption of vitamin B12 in rats","volume":"152","author":"Nabet","year":"1958","journal-title":"C R Seances Soc Biol Fil"},{"key":"key\n\t\t\t\t20180910171309_nuy026-B68","doi-asserted-by":"crossref","first-page":"827","DOI":"10.7326\/0003-4819-83-6-827","article-title":"Spurious Schilling test results obtained with intrinsic factor enclosed in capsules","volume":"83","author":"McDonald","year":"1975","journal-title":"Ann Intern Med."},{"key":"key\n\t\t\t\t20180910171309_nuy026-B69","first-page":"568","article-title":"Simultaneous measurement of free and intrinsic factor (IF) bound vitamin B12 (B12) absorption; absolute quantitation with incomplete stool collection and rapid relative measurement using plasma B12 (IF): B 12 absorption ratio","volume":"14","author":"Fish","year":"1973","journal-title":"J Nucl Med."},{"key":"key\n\t\t\t\t20180910171309_nuy026-B70","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0140-6736(76)91795-5","article-title":"An augmented Schilling test in the diagnosis of pernicious anaemia","volume":"2","author":"Strauchen","year":"1976","journal-title":"Lancet."},{"key":"key\n\t\t\t\t20180910171309_nuy026-B71","first-page":"459","article-title":"Determination of absorption of vitamin B12 by a double isotope tracer technique","volume":"6","author":"Ganatra","year":"1965","journal-title":"J Nucl Med"},{"key":"key\n\t\t\t\t20180910171309_nuy026-B72","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1088\/0031-9155\/14\/3\/307","article-title":"An evaluation of 57-Co-labelled vitamin B12 in a double tracer test of absorption using a whole-body monitor","volume":"14","author":"Boddy","year":"1969","journal-title":"Phys Med Biol."},{"key":"key\n\t\t\t\t20180910171309_nuy026-B73","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/imj.1970.19.1.42","article-title":"A double isotope method to measure vitamin B 12 absorption","volume":"19","author":"Campbell","year":"1970","journal-title":"Australas Ann Med"},{"key":"key\n\t\t\t\t20180910171309_nuy026-B74","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/ajcn\/25.7.703","article-title":"A double-tracer test of the oral absorption of 57 Co- and 58 Co-vitamin B 12 using a whole-body monitor: clinical experience and technical factors","volume":"25","author":"Boddy","year":"1972","journal-title":"Am J Clin Nutr."},{"key":"key\n\t\t\t\t20180910171309_nuy026-B75","first-page":"479","article-title":"[Studies of B12 absorption test with dual-isotope method]","volume":"13","author":"Itaya","year":"1976","journal-title":"Kaku Igaku"},{"key":"key\n\t\t\t\t20180910171309_nuy026-B76","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0609.1974.tb00272.x","article-title":"Vitamin B12 absorption evaluated by a dual isotope test (Dicopac). 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