{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:51:18Z","timestamp":1790661078864,"version":"4.1.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"International Postgraduate Research Scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) are widely considered as nootropic agents that may be beneficial in reversing cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present systematic review of randomized controlled trials was conducted to determine the changes in cognitive function after intervention with LCn-3PUFA supplementation in non-demented adults, including those with mild cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>Five databases (MEDLINE, CINAHL, Scopus, EMBASE, and the Cochrane Library) were searched systematically along with reference lists of selected articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection<\/jats:title>\n                    <jats:p>Studies were eligible for inclusion if they measured the effect of LCn-3PUFA supplementation on cognition in non-demented adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>A total of 787 records were screened, of which 25 studies were eligible for inclusion. Treatment effects were summarized as global cognitive function for primary outcome and measured using the Mini-Mental State Examination and individual cognitive domains for secondary outcome. The pooled effect sizes were estimated using Hedge\u2019s g and random-effects modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>Results from randomized controlled trials indicate that LCn-3PUFAs have no effect on global cognitive function (Hedge\u2019s g\u2009=\u20090.02; 95% confidence interval, \u22120.12 to 0.154), and among the specific cognitive domains, only memory function showed a mild benefit (Hedge\u2019s g\u2009=\u20090.31; P\u2009=\u20090.003; z\u2009=\u20092.945).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The existing literature suggests that LCn-3PUFA supplementation could provide a mild benefit in improving memory function in non-demented older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO registration no. CRD42017078664.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuz073","type":"journal-article","created":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T15:11:08Z","timestamp":1566141068000},"page":"563-578","source":"Crossref","is-referenced-by-count":60,"title":["Long-chain omega-3 polyunsaturated fatty acids and cognitive decline in non-demented adults: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"78","author":[{"given":"Anu","family":"Alex","sequence":"first","affiliation":[{"name":"Nutraceuticals Research Program, School of Biomedical Sciences and Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie A","family":"Abbott","sequence":"additional","affiliation":[{"name":"Nutraceuticals Research Program, School of Biomedical Sciences and Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"McEvoy","sequence":"additional","affiliation":[{"name":"School of Medicine and Public 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