{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:32:43Z","timestamp":1740130363679,"version":"3.37.3"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Protein contact dermatitis (PCD) often presents as chronic hand eczema (CHE) with an immediate hypersensitivity to protein proved by a positive skin prick test or by the presence of specific immunoglobulin E. This is frequently induced by occupational exposure to proteins in food workers, farmers, animal breeders, veterinarians and healthcare professionals. While skin barrier impairment is crucial in the pathogenesis of PCD, methods to assess skin barrier function such as trans-epidermal water loss and stratum corneum hydration are not widely used in clinical settings. We describe the diagnostic workup of occupational PCD due to Argentinean shrimps and discuss how the use of skin bioengineering methods including assessment of corneocytes morphology by Scanning Electron Microscopy provides with insightful information on skin barrier function. Diagnosis of PCD is time-consuming and a multidisciplinary team contributes to early diagnosis and proper occupational rehabilitation.<\/jats:p>","DOI":"10.1093\/occmed\/kqaa005","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T20:08:58Z","timestamp":1578600538000},"page":"282-285","source":"Crossref","is-referenced-by-count":1,"title":["Skin bioengineering in the diagnosis of occupational protein contact dermatitis"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3504-2473","authenticated-orcid":false,"given":"J H","family":"Alfonso","sequence":"first","affiliation":[{"name":"Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Afanou","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-\u00d8","family":"Holm","sequence":"first","affiliation":[{"name":"Department of Dermatology, Oslo University Hospital, Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Stylianou","sequence":"first","affiliation":[{"name":"Regional Centre for Asthma, Allergy and Hypersensitivity, Department of Respiratory Medicine, Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"2020062009232732300_CIT0001","first-page":"552","article-title":"Immediate contact skin reactions, an update of contact urticaria, syndrome and protein contact dermatitis. \u201cA never ending story\u201d","volume":"20","author":"Gimenez-Arnau","year":"2010","journal-title":"Eur J 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