{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:42:55Z","timestamp":1772138575675,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Outbreaks of hypersensitivity pneumonitis (HP) are not uncommon in workplaces where metalworking fluids (MWFs) are used. The recirculation of MWFs leads to microbiological contamination, which is responsible for outbreaks. Most outbreak reports come from USA and the UK; however, no similar reports have been published from Central Europe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To describe an outbreak of MWF-associated HP in workers from a compressor assembly manufacturing facility in Slovak Republic and to identify the potential antigens responsible for the outbreak.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the history of worker\u2019s symptoms, physical examinations, lung function tests, radiographic scans and lung biopsies. The MWF samples were analysed for different strains of bacteria and fungi. Antigen extracts were produced from the microorganisms isolated from MWFs, and positive precipitin reactions were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MWF-associated HP was diagnosed in 21 men and 6 women. All workers had work-related dyspnoea and cough with abnormal pulmonary diffusing capacity. Twenty-four cases had evidence of interstitial lung disease. Four cases were classified as having fibrotic HP. Nineteen microbial isolates (12 bacteria and 7 fungi) were cultured from the MWFs. Twenty-five cases had a positive response to at least one isolate. Eikenella corrodens and Bacillus subtilis were the most frequently reacting antigens (in 15 and 12 workers, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite decreasing reports of MWF-associated HP outbreaks over the past several decades, we describe one of the largest outbreaks in Europe. While the bacterium E. corrodens was found in the MWF samples, its relationship to the disease should be further investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/occmed\/kqac077","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T09:28:52Z","timestamp":1659778132000},"page":"522-526","source":"Crossref","is-referenced-by-count":3,"title":["Machine operator\u2019s lung outbreak due to\n                    <i>Eikenella corrodens<\/i>"],"prefix":"10.1093","volume":"72","author":[{"given":"S","family":"Pere\u010dinsk\u00fd","sequence":"first","affiliation":[{"name":"Department of Occupational Medicine and Clinical Toxicology, Medical Faculty, Pavol Jozef \u0160af\u00e1rik University and the L. Pasteur University Hospital , Rastislavova, Kosice , Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Mur\u00ednov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Clinical Toxicology, Medical Faculty, Pavol Jozef \u0160af\u00e1rik University and the L. Pasteur University Hospital , Rastislavova, Kosice , Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Tom\u010dov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Clinical Toxicology, Medical Faculty, Pavol Jozef \u0160af\u00e1rik University and the L. Pasteur University Hospital , Rastislavova, Kosice , Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Po\u013eanov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, The National Institute of Tuberculosis, Respiratory Diseases and Thoracic Surgery , Vy\u0161n\u00e9 H\u00e1gy, Vysok\u00e9 Tatry , Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u013d","family":"Leg\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Clinical Toxicology, Medical Faculty, Pavol Jozef \u0160af\u00e1rik University and the L. 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