{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:16:09Z","timestamp":1776356169370,"version":"3.51.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Healthcare workers (HCWs) with latent tuberculosis infection (LTBI) have a high risk of active tuberculosis and need systematic LTBI screening and treatment. However, acceptance and adherence rates of LTBI treatment are low.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To examine the specific reasons for the loss at each LTBI treatment-cascade stage: acceptance, continuation and completion of LTBI treatment in HCWs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective descriptive study was conducted among 61 HCWs with an interferon-gamma release assay-confirmed LTBI diagnosis who were prescribed LTBI treatment at a tertiary hospital in the Republic of Korea. Data were analysed using Pearson\u2019s chi-square, Fisher\u2019s exact, independent t-test and Mann\u2013Whitney U-test. A word cloud analysis was used to describe the perceived meaning of LTBI in HCWs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>HCWs who refused or discontinued LTBI treatment perceived LTBI as \u2018not a big deal\u2019, whereas HCWs who completed LTBI treatment had a high-risk perception of the LTBI prognosis, such as \u2018frightened about adverse prognosis\u2019. Determinants of non-adherence to the recommended LTBI treatment included a busy work schedule, side effects of anti-tuberculosis agents and the inconvenience of regularly taking anti-tuberculosis agents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>To ensure LTBI treatment adherence in HCWs, effective interventions that are customized to each stage of the LTBI treatment should be developed, with due consideration of the stage-specific perceived facilitators and barriers in the LTBI treatment cascade.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/occmed\/kqad036","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T20:26:21Z","timestamp":1679948781000},"page":"186-192","source":"Crossref","is-referenced-by-count":7,"title":["Healthcare workers\u2019 acceptance of and adherence to latent tuberculosis treatment"],"prefix":"10.1093","volume":"73","author":[{"given":"H","family":"Yang","sequence":"first","affiliation":[{"name":"Chonnam National University, College of Nursing , Gwangju 61469 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Lee","sequence":"additional","affiliation":[{"name":"Chonnam National University Hwasun Hospital , Hwasun 58128 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kim","sequence":"additional","affiliation":[{"name":"Chonnam National University, College of Nursing , Gwangju 61469 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"2023051900442767700_CIT0001","volume-title":"Global Tuberculosis Report 2017","author":"World Health Organization.","year":"2017"},{"key":"2023051900442767700_CIT0002","volume-title":"WHO End TB Strategy","author":"World Health Organization.","year":"2014"},{"key":"2023051900442767700_CIT0003","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s40272-020-00385-4","article-title":"Vaccine hesitancy: a growing concern","volume":"22","author":"Kennedy","year":"2020","journal-title":"Paediatr Drugs"},{"key":"2023051900442767700_CIT0004","doi-asserted-by":"crossref","first-page":"117594","DOI":"10.1016\/j.lfs.2020.117594","article-title":"Tuberculosis vaccine: a journey from BCG to present","volume":"252","author":"Fatima","year":"2020","journal-title":"Life Sci"},{"key":"2023051900442767700_CIT0005","first-page":"593","article-title":"Risk of tuberculosis infection and disease associated with work in health care settings","volume":"11","author":"Menzies","year":"2007","journal-title":"Int J Tuberc Lung Dis"},{"key":"2023051900442767700_CIT0006","author":"Centers for Disease Control and Prevention.","year":"2019"},{"key":"2023051900442767700_CIT0007","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S1473-3099(16)30216-X","article-title":"The cascade of care in diagnosis and treatment of latent tuberculosis infection: a systematic review and meta-analysis","volume":"16","author":"Alsdurf","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"2023051900442767700_CIT0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-016-1549-4","article-title":"Interventions for improving adherence to treatment for latent tuberculosis infection: a systematic review","volume":"16","author":"Stuurman","year":"2016","journal-title":"BMC Infect Dis"},{"key":"2023051900442767700_CIT0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-016-1550-y","article-title":"Initiation and completion rates for latent tuberculosis infection treatment: a systematic review","volume":"16","author":"Sandgren","year":"2016","journal-title":"BMC Infect Dis"},{"key":"2023051900442767700_CIT0010","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.ajic.2015.07.020","article-title":"Nosocomial exposure to active pulmonary tuberculosis in a neonatal intensive care unit","volume":"43","author":"Ahn","year":"2015","journal-title":"Am J Infect Control"},{"key":"2023051900442767700_CIT0011","doi-asserted-by":"crossref","first-page":"e0121639","DOI":"10.1371\/journal.pone.0121639","article-title":"Tuberculosis transmission from healthcare workers to patients and co-workers: a systematic literature review and meta-analysis","volume":"10","author":"Schepisi","year":"2015","journal-title":"PLoS One"},{"key":"2023051900442767700_CIT0012","volume-title":"7th Korea National Health and Nutrition Examination Survey, 1st Year (2016) Tuberculin Survey Support and Quality Control","author":"Korean National Tuberculosis Association.","year":"2017"},{"key":"2023051900442767700_CIT0013","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/cid\/ciz817","article-title":"Determinants of latent tuberculosis treatment acceptance and completion in healthcare personnel","volume":"71","author":"Swift","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2023051900442767700_CIT0014","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1086\/422995","article-title":"Health care workers and the initiation of treatment for latent tuberculosis infection","volume":"39","author":"Gershon","year":"2004","journal-title":"Clin Infect Dis"},{"key":"2023051900442767700_CIT0015","doi-asserted-by":"crossref","first-page":"853","DOI":"10.7196\/samj.7092","article-title":"Prevalence, risk factors and risk perception of tuberculosis infection among medical students and healthcare workers in Johannesburg, South Africa","volume":"103","author":"Van Rie","year":"2013","journal-title":"S Afr Med J"},{"key":"2023051900442767700_CIT0016","doi-asserted-by":"crossref","first-page":"e0254211","DOI":"10.1371\/journal.pone.0254211","article-title":"\u201cIf I\u2019ve got latent TB, I would like to get rid of it\u201d: derivation of the CARD (Constraints, Actions, Risks, and Desires) Framework informed by South African healthcare worker perspectives on latent tuberculosis treatment","volume":"16","author":"Nathavitharana","year":"2021","journal-title":"PLoS One"},{"key":"2023051900442767700_CIT0017","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1093\/cid\/cix725","article-title":"Management of latent tuberculosis infection among healthcare workers: 10-year experience at a single center","volume":"65","author":"Arguello Perez","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2023051900442767700_CIT0018","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1371\/journal.pmed.0040238","article-title":"Patient adherence to tuberculosis treatment: a systematic review of qualitative research","volume":"4","author":"Munro","year":"2007","journal-title":"PLoS Med"},{"key":"2023051900442767700_CIT0019","doi-asserted-by":"crossref","first-page":"e416","DOI":"10.1002\/hpm.2495","article-title":"Barriers to treatment adherence for individuals with latent tuberculosis infection: a systematic search and narrative synthesis of the literature","volume":"33","author":"Liu","year":"2018","journal-title":"Int J Health Plann Manage"},{"key":"2023051900442767700_CIT0020","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jmii.2013.07.008","article-title":"Prevalence of latent tuberculosis infection in BCG-vaccinated healthcare workers by using an interferon-gamma release assay and the tuberculin skin test in an intermediate tuberculosis burden country","volume":"48","author":"Hung","year":"2015","journal-title":"J Microbiol Immunol Infect"},{"key":"2023051900442767700_CIT0021","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4236\/jtr.2019.72007","article-title":"Selection of health care workers for screening for latent tuberculosis infection","volume":"7","author":"Lee","year":"2019","journal-title":"J Tuberc Res"},{"key":"2023051900442767700_CIT0022","doi-asserted-by":"crossref","first-page":"e0222810","DOI":"10.1371\/journal.pone.0222810","article-title":"Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: a multicentre cohort analysis","volume":"14","author":"Han","year":"2019","journal-title":"PLoS One"},{"key":"2023051900442767700_CIT0023","doi-asserted-by":"crossref","first-page":"e0184061","DOI":"10.1371\/journal.pone.0184061","article-title":"Knowledge about tuberculosis transmission and prevention and perceptions of health service utilization among index cases and contacts in Brazil: understanding losses in the latent tuberculosis cascade of care","volume":"12","author":"Salame","year":"2017","journal-title":"PLoS One"},{"key":"2023051900442767700_CIT0024","author":"TB","year":"2016"},{"key":"2023051900442767700_CIT0025","first-page":"917","article-title":"A comprehensive systematic review of healthcare workers\u2019 perceptions of risk from exposure to emerging acute respiratory infectious diseases and the perceived effectiveness of strategies used to facilitate healthy coping in acute hospital and community healthcare settings","volume":"8","author":"Yiwen","year":"2010","journal-title":"JBI Evid Synth"},{"key":"2023051900442767700_CIT0026","first-page":"201","article-title":"The role of social support on treatment adherence in TB patients: a systematic review","volume":"9","author":"Barik","year":"2020","journal-title":"Nurse and Health: Jurnal Keperawatan"},{"key":"2023051900442767700_CIT0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2458-6-66","article-title":"The impact of smoking on adherence to treatment for latent tuberculosis infection","volume":"6","author":"Lavigne","year":"2006","journal-title":"BMC Public Health"},{"key":"2023051900442767700_CIT0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-63156-8","article-title":"Adherence to nine-month isoniazid for latent tuberculosis infection in healthcare workers: a prospective study in a tertiary hospital","volume":"10","author":"Chung","year":"2020","journal-title":"Sci Rep"}],"container-title":["Occupational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/occmed\/article-pdf\/73\/4\/186\/50388700\/kqad036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/occmed\/article-pdf\/73\/4\/186\/50388700\/kqad036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:45:01Z","timestamp":1684457101000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/occmed\/article\/73\/4\/186\/7087247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,27]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2,27]]},"published-print":{"date-parts":[[2023,5,18]]}},"URL":"https:\/\/doi.org\/10.1093\/occmed\/kqad036","relation":{},"ISSN":["0962-7480","1471-8405"],"issn-type":[{"value":"0962-7480","type":"print"},{"value":"1471-8405","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2023,2,27]]}}}