{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T09:57:51Z","timestamp":1785664671218,"version":"3.56.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"NHS2 II Cohort Infrastructure","award":["U01 CA176726"],"award-info":[{"award-number":["U01 CA176726"]}]},{"name":"ERC-2021-ADG CLOCKrisk","award":["101053225"],"award-info":[{"award-number":["101053225"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Limited and conflicting data exist regarding the impact of first-trimester nursing occupational exposures on hypertensive disorders of pregnancy (HDP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To investigate whether first-trimester night shift work, work hours and work-related activities are associated with HDP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a cross-sectional analysis of 6610 women within the Nurses\u2019 Health Study II. We used multiple logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the relation of occupational exposures to HDP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Nine per cent of respondents reported an HDP in the index pregnancy (gestational hypertension: n\u2005=\u2005354, 5%, preeclampsia: n\u2005=\u2005222, 3%). First-trimester fixed or rotating night shift work was not significantly associated with gestational hypertension or preeclampsia compared to day shift work only. Compared to those working 21\u201340 h\/week, working overtime (\u226541 h\/week) was not associated with gestational hypertension but was associated with 43% higher odds of preeclampsia (95% CI 1.02, 2.00). For part-time work (\u226420 h\/week), the OR was 0.76 (95% CI 0.56, 1.02) for gestational hypertension and 0.64 (95% CI 0.43, 0.97) for preeclampsia. The odds of preeclampsia were 3% higher per additional hour worked per week (95% CI 1.01\u20131.04). Compared to 0\u20134 h spent standing or walking per day, standing or walking \u22659 h daily was associated with 32% lower odds of gestational hypertension (95% CI 0.47, 0.99) but was not significantly associated with preeclampsia. Frequency of heavy lifting was not associated with either hypertensive disorder or pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among nurses, working overtime was associated with higher odds of preeclampsia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/occmed\/kqad089","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T07:45:51Z","timestamp":1692258351000},"page":"419-426","source":"Crossref","is-referenced-by-count":7,"title":["First-trimester occupational exposures and hypertensive disorders of pregnancy among US nurses"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-5660","authenticated-orcid":false,"given":"I","family":"Agarwal","sequence":"first","affiliation":[{"name":"Maine Health Institute for Research, Maine Medical Center , Scarborough 04074, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5605-2016","authenticated-orcid":false,"given":"S","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA 02115 , USA"},{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-2056","authenticated-orcid":false,"given":"S","family":"Strohmaier","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Public Health, Medical University of Vienna , Vienna 1090 , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Schernhammer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA 02115 , USA"},{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115 , USA"},{"name":"Department of Epidemiology, Center for Public Health, Medical University of Vienna , Vienna 1090 , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rich-Edwards","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA 02115 , USA"},{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Kang","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"2024041206340249100_CIT0001","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S2155-8256(21)00027-2","article-title":"The 2020 National Nursing Workforce Survey","volume":"12","author":"Smiley","year":"2021","journal-title":"J Nurs Regul"},{"key":"2024041206340249100_CIT0002","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ajog.2019.06.051","article-title":"The impact of occupational shift work and working hours during pregnancy on health outcomes: a systematic review and meta-analysis","volume":"221","author":"Cai","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"2024041206340249100_CIT0003","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/01.ede.0000259988.77314.a4","article-title":"Work schedule during pregnancy and spontaneous abortion","volume":"18","author":"Whelan","year":"2007","journal-title":"Epidemiology"},{"key":"2024041206340249100_CIT0004","doi-asserted-by":"crossref","first-page":"51.e1","DOI":"10.1016\/j.ajog.2008.08.006","article-title":"Occupational factors and risk of preterm birth in nurses","volume":"200","author":"Lawson","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"2024041206340249100_CIT0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fendo.2013.00092","article-title":"Shift work and circadian dysregulation of reproduction","volume":"4","author":"Gamble","year":"2013","journal-title":"Front Endocrinol 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