{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T13:10:13Z","timestamp":1772025013252,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Italian National Institute for Insurance against Accidents at Work"},{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico","award":["PB-0162"],"award-info":[{"award-number":["PB-0162"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Epithelial sinonasal cancers (SNC) are rare tumours with recognized associations with known\/suspected occupational carcinogens (wood\/leather dust, nickel\/chromium compounds and formaldehyde). In Italy, a national SNC registry organized as a network of regional registries was established by law in 2008.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To describe SNC time trends, occupational exposures and geographical distribution in Lombardy, North-West Italy, based on population registry data (2008\u201320).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Lombardy SNC Registry records epithelial SNCs using various sources. Interviews to collect occupational history are performed using a standardized questionnaire. Using several standard populations, we calculated yearly crude and age-standardized rates (ASRs per 100,000 person-years). Standardized incidence ratios (SIR) at municipality level were calculated, and Bayesian models were fitted to produce smoothed SIR maps.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We recorded 827 cases (553 men, 274 women). Crude (world standardized) ASRs were 0.9 (0.4) in men and 0.4 (0.2) in women, with no time trends. Interviews were obtained for 485 (88%) men and 223 (81%) women. Among men, 217 (45%) had been exposed to occupational carcinogens (wood\/leather dust: 150\/65 cases, 31%\/13%), while only 36 women (16%) were exposed. Among 201 men with adenocarcinoma, exposure to wood\/leather dust occurred in 103\/50 cases (75%\/50%). Areas with elevated SIRs associated with leather dust were found in the Western areas. Exposure to wood dust was more widespread.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study found a high frequency of occupational exposures (wood and leather dust), particularly in men with SNC. Employment in shoe industries clustered in the Western part, while work in furniture industries was less spatially structured.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/occmed\/kqae034","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T01:14:35Z","timestamp":1715908475000},"page":"304-312","source":"Crossref","is-referenced-by-count":4,"title":["Sinonasal cancer incidence in Lombardy, Italy, 2008\u201320"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-3843","authenticated-orcid":false,"given":"D","family":"Consonni","sequence":"first","affiliation":[{"name":"Occupational Health Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan 20122 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Stoppa","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, DCTVPH, University of Padova , Padua 35131 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Binazzi","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, National Institute for Insurance against Accidents at Work (INAIL) , Rome 00143 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Dallari","sequence":"additional","affiliation":[{"name":"Occupational Health Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan 20122 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Stella","sequence":"additional","affiliation":[{"name":"Occupational Health Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan 20122 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rugarli","sequence":"additional","affiliation":[{"name":"Occupational Health Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan 20122 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Trobbiani","sequence":"additional","affiliation":[{"name":"School of Occupational Health, University of Milan , Milan 20122 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Biggeri","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, DCTVPH, University of Padova , Padua 35131 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Catelan","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, DCTVPH, University of Padova , Padua 35131 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Mensi","sequence":"additional","affiliation":[{"name":"Occupational Health Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan 20122 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"2024061110372544400_CIT0001","first-page":"1","article-title":"European position paper on endoscopic management of tumours of the nose, paranasal sinuses, and skull base","volume":"1","author":"Lund","year":"2010","journal-title":"Rhinol Suppl"},{"key":"2024061110372544400_CIT0002","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/hed.21830","article-title":"Incidence, and survival in patients with sinonasal cancer: a historical analysis of population-based data","volume":"34","author":"Turner","year":"2012","journal-title":"Head Neck"},{"key":"2024061110372544400_CIT0003","first-page":"1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El-Naggar","year":"2017","edition":"4"},{"key":"2024061110372544400_CIT0004","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.hoc.2021.05.006","article-title":"Cancer of the paranasal sinuses","volume":"35","author":"Taylor","year":"2021","journal-title":"Hematol Oncol Clin North Am"},{"key":"2024061110372544400_CIT0005","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/bjc.2012.112","article-title":"Occupational cancer burden in Great Britain","volume":"107","author":"Rushton","year":"2012","journal-title":"Br J Cancer"},{"key":"2024061110372544400_CIT0006","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1038\/bjc.2012.118","article-title":"Occupational cancer in Britain. Nasopharynx and sinonasal cancers","volume":"107","author":"Slack","year":"2012","journal-title":"Br J Cancer"},{"key":"2024061110372544400_CIT0007","volume-title":"List of Classifications by Cancer Sites with Sufficient or Limited Evidence in Humans; IARC Monographs","author":"IARC","year":"2023"},{"key":"2024061110372544400_CIT0008","volume-title":"Arsenic, Metals, Fibres, and Dust. Volume 100 C. A Review of Human Carcinogens","author":"IARC","year":"2012"},{"key":"2024061110372544400_CIT0009","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ajim.22789","article-title":"Sinonasal cancer in the Italian national surveillance system: Epidemiology, occupation, and public health implications","volume":"61","author":"Binazzi","year":"2018","journal-title":"Am J Ind Med"},{"key":"2024061110372544400_CIT0010","doi-asserted-by":"crossref","first-page":"672621","DOI":"10.1155\/2013\/672621","article-title":"Sinonasal cancer and occupational exposure in a population-based registry","volume":"2013","author":"Mensi","year":"2013","journal-title":"Int J Otolaryngol"},{"key":"2024061110372544400_CIT0011","volume-title":"ReNaTuNS. Sorveglianza Epidemiologica dei Tumori Naso-Sinusali","author":"Binazzi","year":"2020"},{"key":"2024061110372544400_CIT0012","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/bmj.322.7280.226","article-title":"Sifting the evidence-what\u2019s wrong with significance tests","volume":"322","author":"Sterne","year":"2001","journal-title":"BMJ (Clin Res Ed.)"},{"key":"2024061110372544400_CIT0013","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1177\/1536867X1201200408","article-title":"A command to calculate age-standardized rates with efficient interval estimation","volume":"12","author":"Consonni","year":"2012","journal-title":"Stata J"},{"key":"2024061110372544400_CIT0014","volume-title":"Stata 18. Statistical software","author":"StataCorp","year":"2023"},{"key":"2024061110372544400_CIT0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00031305.2019.1583913","article-title":"Moving to a world beyond \u2018p &lt; 0.05\u2019","volume":"73","author":"Wasserstein","year":"2019","journal-title":"Am Stat"},{"key":"2024061110372544400_CIT0016","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0021-9681(75)90010-7","article-title":"Indirect standardization, and multiplicative models for rates, with reference to the age adjustment of cancer incidence and relative frequency data","volume":"28","author":"Breslow","year":"1975","journal-title":"J Chronic Dis"},{"key":"2024061110372544400_CIT0017","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2307\/2532003","article-title":"Empirical Bayes estimates of age-standardized relative risks for use in disease mapping","volume":"43","author":"Clayton","year":"1987","journal-title":"Biometrics"},{"key":"2024061110372544400_CIT0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00116466","article-title":"Bayesian image restoration, with two applications in spatial statistics","volume":"43","author":"Besag","year":"1991","journal-title":"Ann Inst Stat Math"},{"key":"2024061110372544400_CIT0019","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1023\/A:1008929526011","article-title":"WinBUGS\u2014a Bayesian modelling framework: concepts, structure, and extensibility","volume":"10","author":"Lunn","year":"2000","journal-title":"Stat Comput"},{"key":"2024061110372544400_CIT0020","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1002\/1097-0258(20000915\/30)19:17\/18<2217::AID-SIM565>3.0.CO;2-E","article-title":"Disease mapping models: an empirical evaluation. Disease Mapping Collaborative Group","volume":"19","author":"Lawson","year":"2000","journal-title":"Stat Med"},{"key":"2024061110372544400_CIT0021","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ajim.22789","article-title":"Sinonasal cancer in the Italian national surveillance system: epidemiology, occupation, and public health implications","volume":"61","author":"Binazzi","year":"2018","journal-title":"Am J Ind Med"},{"key":"2024061110372544400_CIT0022","doi-asserted-by":"crossref","first-page":"12593","DOI":"10.3390\/ijerph182312593","article-title":"Exposures to IARC carcinogenic agents in work settings not traditionally associated with sinonasal cancer risk: the experience of the Italian National Sinonasal Cancer Registry","volume":"18","author":"Binazzi","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"2024061110372544400_CIT0023","first-page":"1","article-title":"Italian cancer figures\u2014report 2015. The burden of rare cancers in Italy","volume":"40","author":"AIRTUM Working Group","year":"2016","journal-title":"Epidemiol Prev"},{"key":"2024061110372544400_CIT0024","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S1470-2045(17)30445-X","article-title":"Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet\u2014a population-based study","volume":"18","author":"Gatta","year":"2017","journal-title":"Lancet Oncol"},{"key":"2024061110372544400_CIT0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4193\/Rhino14.070","article-title":"Sinonasal malignancies in Sweden 1960-2010: a nationwide study of the Swedish population","volume":"53","author":"Elliot","year":"2015","journal-title":"Rhinology"},{"key":"2024061110372544400_CIT0026","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.canep.2013.09.014","article-title":"International comparisons of the incidence and mortality of sinonasal cancer","volume":"37","author":"Youlden","year":"2013","journal-title":"Cancer Epidemiol"},{"key":"2024061110372544400_CIT0027","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12901-018-0061-4","article-title":"Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973-2015 database","volume":"18","author":"Gore","year":"2018","journal-title":"BMC Ear Nose Throat Disorders"},{"key":"2024061110372544400_CIT0028","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1002\/lary.25465","article-title":"Sinonasal malignancies: a population-based analysis of site-specific incidence and survival","volume":"125","author":"Dutta","year":"2015","journal-title":"Laryngoscope"},{"key":"2024061110372544400_CIT0029","doi-asserted-by":"crossref","first-page":"106391","DOI":"10.1016\/j.oraloncology.2023.106391","article-title":"Trends in the incidence of head and neck cancer: a nationwide population-based study","volume":"140","author":"Yang","year":"2023","journal-title":"Oral Oncol"},{"key":"2024061110372544400_CIT0030","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1080\/0284186X.2018.1454603","article-title":"Incidence and survival in sinonasal carcinoma: a Danish population-based, nationwide study from 1980 to 2014","volume":"57","author":"Sj\u00f6stedt","year":"2018","journal-title":"Acta Oncol"},{"key":"2024061110372544400_CIT0031","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S0022215121003522","article-title":"Fifty years of woodworkers\u2019 nasal adenocarcinoma in High Wycombe","volume":"136","author":"Capper","year":"2022","journal-title":"J Laryngol Otol"},{"key":"2024061110372544400_CIT0032","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1186\/1471-2407-12-506","article-title":"Risk factors for nasal malignancies in German men: the South-German Nasal cancer study","volume":"12","author":"Greiser","year":"2012","journal-title":"BMC Cancer"}],"container-title":["Occupational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/occmed\/article-pdf\/74\/4\/304\/58195454\/kqae034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/occmed\/article-pdf\/74\/4\/304\/58195454\/kqae034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T21:39:41Z","timestamp":1718141981000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/occmed\/article\/74\/4\/304\/7675493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,5,16]]},"published-print":{"date-parts":[[2024,6,11]]}},"URL":"https:\/\/doi.org\/10.1093\/occmed\/kqae034","relation":{},"ISSN":["0962-7480","1471-8405"],"issn-type":[{"value":"0962-7480","type":"print"},{"value":"1471-8405","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,5]]}}}