{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:08:50Z","timestamp":1784686130122,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3-4","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Exposure to benzene is a widespread occupational hazard that has been associated with haematopoietic neoplasms. The increasing awareness of the health effects that can arise from extended dermal contact with aromatic hydrocarbons, such as benzene, may elevate the risk of skin cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study addresses the association between occupational benzene exposure and its incidence and mortality, encompassing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma, as well as cutaneous melanoma (CM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>After removing duplicates, we screened 5652 articles from four different sources (Embase, Pubmed, Scopus and IARC Monographs), retrieving 29 independent studies on occupational benzene exposure and skin cancer. The meta-analysis used a random-effects model, overall and stratifying by gender, publication year, outcome, geographic region, industry type and study design.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The analysis encompasses 18 risk estimates on CM and 21 on either NMSC or not-specified skin cancer (NM\/NS) mostly from Europe and North America and predominantly from oil industry cohorts. There was no association with either CM (relative risk [RR]\u2005=\u20050.99, 95% confidence interval [CI] 0.81; 1.21) or NM\/NS (RR\u2005=\u20051.19, 95% CI 0.94; 1.50), except for a positive association between employment in the chemical industry and NM\/NS risk. There was no evidence of publication bias for either type of cancer (P\u2005=\u20050.70 and P\u2005=\u20050.08).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our meta-analysis found no association between occupational benzene exposure and skin cancer. Further research should aim to describe the association of benzene exposure with skin cancer in less developed countries and among various occupations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/occmed\/kqae112","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T17:06:26Z","timestamp":1741107986000},"page":"163-170","source":"Crossref","is-referenced-by-count":5,"title":["Occupational benzene exposure and skin cancers: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1061-065X","authenticated-orcid":false,"given":"M","family":"Angelini","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna , Bologna, 40138 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-9128","authenticated-orcid":false,"given":"M S","family":"Seyyedsalehi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna , Bologna, 40138 ,","place":["Italy"]},{"name":"Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences , Tehran, 1446667451 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna , Bologna, 40138 ,","place":["Italy"]},{"name":"Stony Brook Cancer Center, Stony Brook University , Stony Brook, NY, 11794 ,","place":["USA"]},{"name":"Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY, 11794 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"2025071508370207700_CIT0001","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2025071508370207700_CIT0002","doi-asserted-by":"publisher","first-page":"adv00136","DOI":"10.2340\/00015555-3491","article-title":"Melanoma epidemiology and sun exposure","volume":"100","author":"Raimondi","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"2025071508370207700_CIT0003","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/cam4.404","article-title":"Cutaneous squamous cell carcinoma in Norway 1963-2011: increasing incidence and stable mortality","volume":"4","author":"Robsahm","year":"2015","journal-title":"Cancer Med"},{"key":"2025071508370207700_CIT0004","first-page":"35","author":"International Agency for Research on Cancer. 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