{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:54:31Z","timestamp":1780545271560,"version":"3.54.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100007546","name":"Agence Nationale de S\u00e9curit\u00e9 Sanitaire de l\u2019Alimentation, de l\u2019Environnement et du Travail","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007546","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Systemic sclerosis (SSc) is the connective tissue disease with the highest individual mortality. Crystalline silica is known to be an occupational risk factor for SSc. To assess past crystalline silica exposure, we aimed to study the validity of a job exposure matrix (JEM) to assess occupational exposure to crystalline silica compared to specific occupational interviews in two populations of SSc patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To demonstrate the reliability of JEM for the assessment of occupational exposure to hazards such as silica, in severe rare disorders like SSc.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients from two university hospital centres underwent standardized assessment of occupational silica exposure and collected job histories through face-to-face interviews. A JEM from the French program Matg\u00e9n\u00e9 was used to assess silica exposure and compared to the standardized interview results. Standard metrics were computed for evaluate the accuracy of JEM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>67 participants from Rennes, and 119 from Tours were included, with respectively 10.5% and 18.0% of patients with silica exposure based on the results of the interview. The JEM with 50% probability cut-off had a good performance when compared with the classic assessment method. A cumulative exposure index from JEM over 250 had an area under the curve between 0.76 and 0.79 and also a very high positive likelihood ratio (17.14 and 10.29).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite limitations inherent to JEMs and associated validation methods, the JEM used in this setting provided accurate results to assess occupational exposure to crystalline silica for clinical purposes such as in SSc patients, especially to detect positive cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/occmed\/kqae133","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T22:20:50Z","timestamp":1738189250000},"page":"65-68","source":"Crossref","is-referenced-by-count":3,"title":["Job-exposure matrix (JEM) validity on crystalline silica among systemic sclerosis patients"],"prefix":"10.1093","volume":"75","author":[{"given":"M","family":"Touchard","sequence":"first","affiliation":[{"name":"Maine et Loire, Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S 1085, IRSET-ESTER, SFR ICAT, CAPTV CDC , 49000 Angers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Ille et Vilaine, Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sant\u00e9, Environnement et Travail) \u2013 UMR_S 1085 , 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-4524","authenticated-orcid":false,"given":"B","family":"Thoreau","sequence":"additional","affiliation":[{"name":"Indre et Loire, Service de M\u00e9decine Interne et d\u2019Immunologie Clinique, CHRU Tours, Universit\u00e9 de Tours , 37000 Tours ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-0021","authenticated-orcid":false,"given":"M","family":"Fadel","sequence":"additional","affiliation":[{"name":"Maine et Loire, Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S 1085, IRSET-ESTER, SFR ICAT, CAPTV CDC , 49000 Angers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Zavarsky","sequence":"additional","affiliation":[{"name":"Ille et Vilaine, Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sant\u00e9, Environnement et Travail) \u2013 UMR_S 1085 , 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Diot","sequence":"additional","affiliation":[{"name":"Indre et Loire, Service de M\u00e9decine Interne et d\u2019Immunologie Clinique, CHRU Tours, Universit\u00e9 de Tours , 37000 Tours ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lescoat","sequence":"additional","affiliation":[{"name":"Maine et Loire, Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S 1085, IRSET-ESTER, SFR ICAT, CAPTV CDC , 49000 Angers ,","place":["France"]},{"name":"Ille et Vilaine, Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sant\u00e9, Environnement et Travail) \u2013 UMR_S 1085 , 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Le Roux","sequence":"additional","affiliation":[{"name":"Maine et Loire, Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S 1085, IRSET-ESTER, SFR ICAT, CAPTV CDC , 49000 Angers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6028-3186","authenticated-orcid":false,"given":"A","family":"Descatha","sequence":"additional","affiliation":[{"name":"Maine et Loire, Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S 1085, IRSET-ESTER, SFR ICAT, CAPTV CDC , 49000 Angers ,","place":["France"]},{"name":"Department of Occupational Medicine, Epidemiology and Prevention, Donald and Barbara Zucker School of Medicine , Hofstra\/Northwell, Hempstead, NY 11549 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"2025040707243177400_CIT0001","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic 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