{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T10:24:59Z","timestamp":1787480699468,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>This report is based on a case of a retired painter erroneously diagnosed with elevated serum aluminium levels. It highlights the problematic nature of serum aluminium testing, particularly when undertaken without convincing clinical support for excessive aluminium exposure.<\/jats:p>\n                  <jats:p>Here, we report on a retired painter, living near an automotive manufacturing plant, found to have elevated serum aluminium levels as part of comprehensive investigations for neuropsychiatric symptoms. His case coincided with a cluster of referrals to local toxicologists for elevated aluminium levels. Further investigations revealed a flaw in the laboratory testing protocol as the source of falsely elevated results. This case highlights the problematic nature of serum aluminium testing, particularly when undertaken without a convincing clinical correlation for toxicity.<\/jats:p>","DOI":"10.1093\/occmed\/kqaf098","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T11:42:03Z","timestamp":1756640523000},"page":"646-648","source":"Crossref","is-referenced-by-count":1,"title":["Pitfalls of serum aluminium testing"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9979-2260","authenticated-orcid":false,"given":"Nisha","family":"Fernandes","sequence":"first","affiliation":[{"name":"Department of Medicine, Markham-Stouffville Hospital , 381 Church Street , Markham, ON L3P 7P3,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Mazzetti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Schulich School of Medicine, Western University , London, ON,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Spilchuk","sequence":"additional","affiliation":[{"name":"Division of Occupational Medicine, Faculty of Medicine, University of Toronto , Toronto,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Holbrook","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Department of Medicine, McMaster University , Hamilton, ON,","place":["Canada"]},{"name":"Clinical Pharmacology Research, Research Institute of St Joseph\u2019s Hamilton , Hamilton, ON,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"2026011213300630300_kqaf098-B1","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1007\/s00204-019-02599-z","article-title":"Aggregated aluminium exposure: risk assessment for the general population","volume":"93","author":"Tietz","year":"2019","journal-title":"Arch Toxicol"},{"key":"2026011213300630300_kqaf098-B2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s13181-013-0343-6","article-title":"The role of chelation in the treatment of other metal poisonings","volume":"9","author":"Smith","year":"2013","journal-title":"J Med Toxicol"},{"key":"2026011213300630300_kqaf098-B3","author":"Toxicological Profile for Aluminum","year":"2008"},{"key":"2026011213300630300_kqaf098-B4","year":"2024"},{"key":"2026011213300630300_kqaf098-B5","doi-asserted-by":"crossref","first-page":"126830","DOI":"10.1016\/j.jtemb.2021.126830","article-title":"Multi-elemental determination of metals, metalloids and rare earth element concentrations in whole blood from the Canadian Health Measures Survey, 2009-2011","volume":"68","author":"Jayawardene","year":"2021","journal-title":"J Trace Elem Med Biol"},{"key":"2026011213300630300_kqaf098-B6"},{"key":"2026011213300630300_kqaf098-B7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/bpa.12333","article-title":"Understanding aspects of aluminum exposure in Alzheimer\u2019s disease development","volume":"26","author":"Kandimalla","year":"2016","journal-title":"Brain Pathol"},{"key":"2026011213300630300_kqaf098-B8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1258\/0004563053026862","article-title":"Plasma aluminium: a redundant test for patients on dialysis?","volume":"42","author":"Gault","year":"2005","journal-title":"Ann Clin Biochem"},{"key":"2026011213300630300_kqaf098-B9","first-page":"153","article-title":"Determination of aluminum concentrations in biological specimens: application in the clinical \u00adlaboratory","volume":"3","author":"P\u00e9rez","year":"2022","journal-title":"Adv Lab Med"},{"key":"2026011213300630300_kqaf098-B10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.5858\/arpa.2017-0049-OA","article-title":"Aluminum toxicity: evaluation of 16-year trend among 14\u2009919 patients and 45\u2009480 results","volume":"142","author":"Schifman","year":"2018","journal-title":"Arch Pathol Lab Med"}],"container-title":["Occupational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/occmed\/article-pdf\/75\/9\/646\/64415493\/kqaf098.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/occmed\/article-pdf\/75\/9\/646\/64415493\/kqaf098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T18:30:12Z","timestamp":1768242612000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/occmed\/article\/75\/9\/646\/8266450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9,26]]},"published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/occmed\/kqaf098","relation":{},"ISSN":["0962-7480","1471-8405"],"issn-type":[{"value":"0962-7480","type":"print"},{"value":"1471-8405","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,9,26]]}}}