{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:36:57Z","timestamp":1793824617246,"version":"4.6.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001861","name":"Swedish Council for Working Life and Social Research","doi-asserted-by":"publisher","award":["2011-426"],"award-info":[{"award-number":["2011-426"]}],"id":[{"id":"10.13039\/501100001861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aetiology of sarcoidosis is not well established. In previous studies, smoking has been negatively associated with sarcoidosis and there are some indications of an association between exposure to silica dust and sarcoidosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To study the risk of sarcoidosis in relation to silica dust exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A longitudinal cohort of construction workers linked with a registry of Swedish inpatient diagnoses. Workers were designated as exposed or unexposed to silica based on job titles in a job\u2013exposure matrix. The relative risk (RR) was analysed with Poisson regression adjusting for age and smoking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 371 cases of sarcoidosis among 297 917 male workers. There was an increased risk of sarcoidosis in the medium- to high-exposure group [RR 1.83 (95% confidence interval {CI} 1.14\u20132.95)]. A stratified analysis according to smoking showed that ever-smoking workers had an increased risk of sarcoidosis if highly exposed to silica dust [RR 2.44 (95% CI 1.37\u20134.33)] compared to non-exposed ever-smokers. The risk of non-smokers highly exposed to silica was not significantly increased [RR 1.07 (95% CI 0.72\u20131.58)] compared to non-exposed non-smokers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The study indicates an increased risk of developing sarcoidosis in ever-smoking men exposed to silica.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/occmed\/kqz118","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T15:11:28Z","timestamp":1564672288000},"page":"482-486","source":"Crossref","is-referenced-by-count":47,"title":["Silica dust and sarcoidosis in Swedish construction workers"],"prefix":"10.1093","volume":"69","author":[{"given":"E","family":"Jonsson","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"J\u00e4rvholm","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,24]]},"reference":[{"key":"2019121611071956400_CIT0001","first-page":"113","article-title":"Pulmonary sarcoidosis in the Nordic countries 1950\u20131982. II. Course and prognosis","volume":"7","author":"Milman","year":"1990","journal-title":"Sarcoidosis"},{"key":"2019121611071956400_CIT0002","first-page":"736","article-title":"Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999","volume":"160","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2019121611071956400_CIT0003","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12016-015-8481-z","article-title":"Etiologies of sarcoidosis","volume":"49","author":"Chen","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"2019121611071956400_CIT0004","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1183\/09031936.98.12051197","article-title":"Seasonal clustering of sarcoidosis presenting with erythema nodosum","volume":"12","author":"Wilsher","year":"1998","journal-title":"Eur Respir J"},{"key":"2019121611071956400_CIT0005","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1164\/rccm.200402-249OC","article-title":"A case control etiologic study of sarcoidosis: environmental and occupational risk factors","volume":"170","author":"Newman","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"2019121611071956400_CIT0006","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1136\/oem.60.2.122","article-title":"Occupational silica exposure and risk of various diseases: an analysis using death certificates from 27 states of the United States","volume":"60","author":"Calvert","year":"2003","journal-title":"Occup Environ Med"},{"key":"2019121611071956400_CIT0007","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/oem.55.10.657","article-title":"Association between exposure to crystalline silica and risk of sarcoidosis","volume":"55","author":"Rafnsson","year":"1998","journal-title":"Occup Environ Med"},{"key":"2019121611071956400_CIT0008","doi-asserted-by":"crossref","first-page":"e016839","DOI":"10.1136\/bmjopen-2017-016839","article-title":"Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study","volume":"7","author":"Vihlborg","year":"2017","journal-title":"BMJ Open"},{"key":"2019121611071956400_CIT0009","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.amjmed.2015.05.001","article-title":"Prospective risk of rheumatologic disease associated with occupational exposure in a cohort of male construction workers","volume":"128","author":"Blanc","year":"2015","journal-title":"Am J Med"},{"key":"2019121611071956400_CIT0010","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1378\/chest.13-1429","article-title":"Effect of occupational exposure to vapors, gases, dusts, and fumes on COPD mortality risk among Swedish construction workers: a longitudinal cohort study","volume":"145","author":"Tor\u00e9n","year":"2014","journal-title":"Chest"},{"key":"2019121611071956400_CIT0011","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(13)60680-7","article-title":"Sarcoidosis","volume":"383","author":"Valeyre","year":"2014","journal-title":"Lancet"},{"key":"2019121611071956400_CIT0012","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/ajim.4700280505","article-title":"Silica exposure and autoimmune diseases","volume":"28","author":"Steenland","year":"2017","journal-title":"Am J Ind Med"},{"key":"2019121611071956400_CIT0013","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/thx.43.7.516","article-title":"Smoking and pulmonary sarcoidosis: effect of cigarette smoking on prevalence, clinical manifestations, alveolitis, and evolution of the disease","volume":"43","author":"Valeyre","year":"1988","journal-title":"Thorax"},{"key":"2019121611071956400_CIT0014","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1749-6632.1986.tb18539.x","article-title":"Reduced prevalence of smokers in sarcoidosis. Results of a case-control study","volume":"465","author":"Harf","year":"1986","journal-title":"Ann N Y Acad Sci"},{"key":"2019121611071956400_CIT0015","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1136\/thx.41.10.787","article-title":"Sarcoidosis: a disorder commoner in non-smokers?","volume":"41","author":"Douglas","year":"1986","journal-title":"Thorax"},{"key":"2019121611071956400_CIT0016","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1749-6632.1986.tb18541.x","article-title":"Smoking and interstitial lung disease. The effect of cigarette smoking on the incidence of pulmonary histiocytosis X and sarcoidosis","volume":"465","author":"Hance","year":"1986","journal-title":"Ann N Y Acad Sci"},{"key":"2019121611071956400_CIT0017","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1164\/rccm.200909-1338OC","article-title":"Smoking, use of moist snuff, and risk of chronic inflammatory diseases","volume":"181","author":"Carlens","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2019121611071956400_CIT0018","first-page":"19","article-title":"Is tobacco smoking protective for sarcoidosis? A case-control study from North India","volume":"27","author":"Gupta","year":"2010","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2019121611071956400_CIT0019","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.rmed.2016.10.003","article-title":"Smoking, obesity and risk of sarcoidosis: a population-based nested case-control study","volume":"120","author":"Ungprasert","year":"2016","journal-title":"Respir Med"}],"container-title":["Occupational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/occmed\/article-pdf\/69\/7\/482\/31550480\/kqz118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/occmed\/article-pdf\/69\/7\/482\/31550480\/kqz118.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T11:17:53Z","timestamp":1576495073000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/occmed\/article\/69\/7\/482\/5554863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,24]]},"references-count":19,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,8,24]]},"published-print":{"date-parts":[[2019,12,7]]}},"URL":"https:\/\/doi.org\/10.1093\/occmed\/kqz118","relation":{},"ISSN":["0962-7480","1471-8405"],"issn-type":[{"value":"0962-7480","type":"print"},{"value":"1471-8405","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10]]},"published":{"date-parts":[[2019,8,24]]}}}