{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:50:33Z","timestamp":1760205033640,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T00:00:00Z","timestamp":1570320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Possible factors for cell atypia in nasal mucosa include noxious chemicals: ammonia, formaldehyde and heavy metals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Case presentation of a nasal polyp with epithelial dysplasia in a worker exposed to nickel and copper salt dust.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case report<\/jats:title>\n                  <jats:p>A 27-year-old man complained of impaired nasal breathing and mild right-sided epistaxis. He was exposed to copper and nickel salt dust for 6 years. Clinical examination showed a polypoid lesion arising from the right middle turbinate. Histopathological examination of the excised lesion showed high-grade epithelial dysplasia. Duration of exposure and concentration of heavy metals in serum suggest the biological plausibility of exposure to these factors and development of epithelial dysplasia in the nasal mucosa.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Epithelial dysplasia may occasionally be noted in inflammatory nasal polyps, especially in workers exposed to heavy metals.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/occmed\/kqz123","type":"journal-article","created":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T03:32:15Z","timestamp":1567308735000},"source":"Crossref","is-referenced-by-count":2,"title":["Nasal polyp epithelial atypia and exposure to nickel and copper"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8453-7272","authenticated-orcid":false,"given":"A","family":"Peri\u0107","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Military Medical Academy Faculty of Medicine, Crnotravska, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Vukomanovi\u0107 \u0110ur\u0111evi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Military Medical Academy Faculty of Medicine, Crnotravska, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,6]]},"reference":[{"key":"2019100609382881300_CIT0001","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/coa.12157","article-title":"The site of origin of nasal polyposis in the ethmoid subcompartments assessed from clinical observation of ninety-four nasal cavities","volume":"38","author":"Benamara","year":"2013","journal-title":"Clin Otolaryngol"},{"key":"2019100609382881300_CIT0002","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/0194599817711887","article-title":"Polypoid change of the middle turbinate and paranasal sinus polyposis are distinct entities","volume":"157","author":"Brunner","year":"2017","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2019100609382881300_CIT0003","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2500\/ajra.2014.28.4003","article-title":"Histological characteristics of chronic rhinosinusitis with nasal polyps: recent 10-year experience of a single center in Daegu, Korea","volume":"28","author":"Shin","year":"2014","journal-title":"Am J Rhinol Allergy"},{"key":"2019100609382881300_CIT0004","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1017\/S002221510014160X","article-title":"Epithelial atypia and squamous metaplasia in nasal polyps","volume":"112","author":"Baird","year":"1998","journal-title":"J Laryngol Otol"},{"key":"2019100609382881300_CIT0005","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/bjc.1979.222","article-title":"Histopathological changes of the nasal mucosa in active and retired nickel workers","volume":"40","author":"Torjussen","year":"1979","journal-title":"Br J Cancer"},{"key":"2019100609382881300_CIT0006","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(197909)44:3<963::AID-CNCR2820440326>3.0.CO;2-H","article-title":"Histopathologic changes of nasal mucosa in nickel workers: a pilot study","volume":"44","author":"Torjussen","year":"1979","journal-title":"Cancer"},{"key":"2019100609382881300_CIT0007","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/00016487909137170","article-title":"Rhinoscopical findings in nickel workers, with special emphasis on the influence of nickel exposure and smoking habits","volume":"88","author":"Torjussen","year":"1979","journal-title":"Acta Otolaryngol"},{"key":"2019100609382881300_CIT0008","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5271\/sjweh.2861","article-title":"Changes in the nasal mucosa after exposure to copper salt dust. 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