{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:19:23Z","timestamp":1778717963765,"version":"3.51.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GlaxoSmithKline Biologicals SA"},{"DOI":"10.13039\/501100003032","name":"Association Nationale pour la Recherche et la Technologie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003032","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although rotavirus vaccines have proven to prevent the risk of rotavirus gastroenteritis (RVGE) in children under 5 years old, they are also associated with an increased transient risk of intussusception (IS). Several quantitative benefit-risk models (qBRm) are performed to measure this balance in hospitalizations and deaths prevented versus the ones induced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this study, our objective was to provide a complete overview of qBRm used for rotavirus vaccination. We systematically searched 3 medical literature databases to identify relevant articles, in English, that were published between 2006 and 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 276 publications screened, 14 studies using qBRm for rotavirus vaccination were retained, based on preselected criteria. Four were performed in low- and middle-income countries. Almost all (13 of 14) displayed the following characteristics: force of infection assumed to be constant over time (static model), indirect effect of rotavirus vaccination (herd effect) not considered, closed model (individuals not allowed to enter and\/or exit the model over time), and aggregated level (no tracking of individual\u2019s behavior). Most of the models were probabilistic (9 of 14) and reported sensitivity and\/or scenario analyses (12 of 14). Input parameter values varied across studies. Selected studies suggest that, depending on the models used, for every IS hospitalization and death induced, vaccination would prevent, respectively, 190\u20131624 and 71\u2013743 RVGE-related hospitalizations and deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The benefits of rotavirus vaccination were shown to largely exceed the increased risk of IS, across all studies. Future research aiming to harmonize qBRm for rotavirus vaccination should ensure the comparability of studies and provide additional information for regulatory authorities, physicians, and patients.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ofid\/ofaa087","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T08:37:33Z","timestamp":1584002253000},"source":"Crossref","is-referenced-by-count":5,"title":["Quantitative Benefit-Risk Models Used for Rotavirus Vaccination: A Systematic Review"],"prefix":"10.1093","volume":"7","author":[{"given":"Hugo","family":"Arlegui","sequence":"first","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, University of Bordeaux, Bordeaux, France"},{"name":"Pharmaco-Epidemiology and Health Outcomes Research, GSK, Rueil-Malmaison, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Nachbaur","sequence":"first","affiliation":[{"name":"Pharmaco-Epidemiology and Health Outcomes Research, GSK, Rueil-Malmaison, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Praet","sequence":"first","affiliation":[{"name":"Clinical Research and Development, GSK, Wavre, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"B\u00e9gaud","sequence":"first","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, University of Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"2020060204000106300_CIT0001","first-page":"49","article-title":"Rotavirus vaccines. 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