{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:42:15Z","timestamp":1784194935965,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["095778"],"award-info":[{"award-number":["095778"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107743"],"award-info":[{"award-number":["107743"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DELTAS Africa Initiative","award":["107743"],"award-info":[{"award-number":["107743"]}]},{"DOI":"10.13039\/501100011858","name":"African Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014163","name":"Alliance for Accelerating Excellence in Science in Africa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009250","name":"New Partnership for Africa's Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K012126\/1"],"award-info":[{"award-number":["MR\/K012126\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK Department for International Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Praziquantel mass drug administration (MDA) is recommended in schistosomiasis-endemic areas. Animal models demonstrate Schistosoma parasite resistance to praziquantel after repeated exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a parasitological survey in 26 fishing communities in Uganda after 4 years of quarterly (13 communities) or annual (13 communities) praziquantel MDA, with Schistosoma infection detected by single-stool-sample Kato-Katz. A test of cure was done in participants who were positive on both urine circulating cathodic antigen test and 3-sample Kato-Katz. We calculated cure rates (CRs) and egg reduction rates (ERRs) based on 3-sample Kato-Katz and infection intensity using worm-specific circulating anodic antigen (CAA) in blood, comparing these between quarterly and annually treated participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Single-sample Kato-Katz Schistosoma mansoni prevalence was 22% in 1,056 quarterly treated participants and 34% in 1,030 annually treated participants (risk ratio, 0.62; 95% confidence interval [CI], 0.40 to 0.94). Among 110 test-of-cure participants, CRs were 65% and 51% in annually and quarterly treated villages, respectively (odds ratio, 0.65; 95% CI, 0.27 to 1.58); ERRs were 94% and 81% (difference, \u201313%; 95% CI, \u201348% to 2%). There was no impact of quarterly vs annual praziquantel on S. mansoni by CAA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this schistosomiasis hot spot, there was little evidence of decreased praziquantel efficacy. However, in the absence of alternative therapies, there remains a need for continued vigilance of praziquantel efficacy in the MDA era.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaa091","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T02:27:30Z","timestamp":1584066450000},"source":"Crossref","is-referenced-by-count":7,"title":["Does Intensive Treatment Select for Praziquantel Resistance in High-Transmission Settings? Parasitological Trends and Treatment Efficacy Within a Cluster-Randomized Trial"],"prefix":"10.1093","volume":"7","author":[{"given":"John Vianney","family":"Tushabe","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"},{"name":"Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Lubyayi","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Sserubanja","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prossy","family":"Kabuubi","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elson","family":"Abayo","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kiwanuka","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacent","family":"Nassuuna","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kaweesa","sequence":"first","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Corstjens","sequence":"first","affiliation":[{"name":"Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govert","family":"van Dam","sequence":"first","affiliation":[{"name":"Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E","family":"Sanya","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"},{"name":"Department of Internal Medicine, College of Health Sciences, Makerere University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Ssenyonga","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edridah Muheki","family":"Tukahebwa","sequence":"first","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcis B","family":"Kabatereine","sequence":"first","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M","family":"Elliott","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Research Programme, Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda"},{"name":"Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4019-7456","authenticated-orcid":false,"given":"Emily L","family":"Webb","sequence":"first","affiliation":[{"name":"MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"LaVIISWA trial team","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Nampijja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Mpairwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Nerima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Serubanja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Lubyayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hellen","family":"Akurut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Okello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Owilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Ochola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Zziwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milly","family":"Namutebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Nakazibwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Tumusiime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Ninsiima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Amongi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Kamukama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Iwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Asherwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehema","family":"Nampijja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Akello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirriam","family":"Akello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kizindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Sewankambo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Nsubuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Cose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prossy Kabuubi","family":"Nakawungu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Niwagaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Oduru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Kabami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elson","family":"Abayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred Muwonge","family":"Kakooza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Kabagenyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyaviira","family":"Nkurunungi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Nalwoga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Vianney","family":"Tushabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacent","family":"Nassuuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridgious","family":"Walusimbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Abiriga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Walusimbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Kabonesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kaweesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edridah","family":"Tukahebwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Kizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"2020041015552391900_CIT0001","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"2020041015552391900_CIT0002","doi-asserted-by":"crossref","first-page":"E111","DOI":"10.3390\/tropicalmed3040111","article-title":"Low praziquantel treatment coverage for Schistosoma mansoni in Mayuge District, Uganda, due to the absence of treatment opportunities, rather than systematic non-compliance","volume":"3","author":"Adriko","year":"2018","journal-title":"Trop Med Infect Dis"},{"key":"2020041015552391900_CIT0003","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/QCO.0b013e328318978f","article-title":"Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis","volume":"21","author":"Doenhoff","year":"2008","journal-title":"Curr Opin Infect Dis"},{"key":"2020041015552391900_CIT0004","volume-title":"Report of an Informal Consultation on Schistosomiasis Control","author":"World Health Organization","year":"2011"},{"key":"2020041015552391900_CIT0005","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.ijpara.2011.06.002","article-title":"Schistosoma mansoni population structure and persistence after praziquantel treatment in two villages of Bahia, Brazil","volume":"41","author":"Blanton","year":"2011","journal-title":"Int J Parasitol"},{"key":"2020041015552391900_CIT0006","first-page":"1151","article-title":"Reduced efficacy of praziquantel against Schistosoma mansoni is associated with multiple rounds of mass drug administration","volume":"63","author":"Crellen","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2020041015552391900_CIT0007","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/QCO.0000000000000312","article-title":"Mass drug administration and the global control of schistosomiasis: successes, limitations and clinical outcomes","volume":"29","author":"Olveda","year":"2016","journal-title":"Curr Opin Infect Dis"},{"key":"2020041015552391900_CIT0008","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s13071-015-1144-3","article-title":"Modelling control of Schistosoma haematobium infection: predictions of the long-term impact of mass drug administration in Africa","volume":"8","author":"Gurarie","year":"2015","journal-title":"Parasit Vectors"},{"key":"2020041015552391900_CIT0009","first-page":"e0005982","article-title":"Perceptions about interventions to control schistosomiasis among the Lake Victoria island communities of Koome, Uganda","volume-title":"PLOS Negl Trop Dis","author":"Sanya","year":"2018"},{"key":"2020041015552391900_CIT0010","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3109\/13880209.2014.970289","article-title":"Evaluation of a method for induction of praziquantel resistance in Schistosoma mansoni","volume":"53","author":"Lotfy","year":"2015","journal-title":"Pharm Biol"},{"key":"2020041015552391900_CIT0011","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4269\/ajtmh.1995.53.61","article-title":"Short report: diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni","volume":"53","author":"Fallon","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"2020041015552391900_CIT0012","doi-asserted-by":"crossref","first-page":"e2596","DOI":"10.1371\/journal.pntd.0002596","article-title":"Praziquantel treatment decreases Schistosoma mansoni genetic diversity in experimental infections","volume":"7","author":"Coeli","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"2020041015552391900_CIT0013","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3389\/fmicb.2016.00594","article-title":"Morphological characteristics of Schistosoma mansoni PZQ-resistant and -susceptible strains are different in presence of praziquantel","volume":"7","author":"Pinto-Almeida","year":"2016","journal-title":"Front Microbiol"},{"key":"2020041015552391900_CIT0014","doi-asserted-by":"crossref","first-page":"e0140147","DOI":"10.1371\/journal.pone.0140147","article-title":"The role of efflux pumps in Schistosoma mansoni praziquantel resistant phenotype","volume":"10","author":"Pinto-Almeida","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"2020041015552391900_CIT0015","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/cid\/ciy761","article-title":"The impact of intensive versus standard anthelminthic treatment on allergy-related outcomes, helminth infection intensity and helminth-related morbidity in Lake Victoria fishing communities, Uganda: results from the LaVIISWA cluster randomised trial","volume":"68","author":"Sanya","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2020041015552391900_CIT0016","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13063-015-0702-5","article-title":"The Lake Victoria Island Intervention Study on Worms and Allergy-Related Diseases (LaVIISWA): study protocol for a randomised controlled trial","volume":"16","author":"Nampijja","year":"2015","journal-title":"Trials"},{"key":"2020041015552391900_CIT0017","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.inhe.2012.03.003","article-title":"Treatment of schistosomiasis in African infants and preschool-aged children: downward extension and biometric optimization of the current praziquantel dose pole","volume":"4","author":"Sousa-Figueiredo","year":"2012","journal-title":"Int Health"},{"key":"2020041015552391900_CIT0018","doi-asserted-by":"crossref","first-page":"e2843","DOI":"10.1371\/journal.pntd.0002843","article-title":"Diagnostic accuracy and cost-effectiveness of alternative methods for detection of soil-transmitted helminths in a post-treatment setting in Western Kenya","volume":"8","author":"Assefa","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"2020041015552391900_CIT0019","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s10096-018-3303-x","article-title":"Improved diagnosis of active Schistosoma infection in travellers and migrants using the ultra-sensitive in-house lateral flow test for detection of circulating anodic antigen (CAA) in serum","volume":"37","author":"van Grootveld","year":"2018","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2020041015552391900_CIT0020","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1017\/S0031182014000626","article-title":"Tools for diagnosis, monitoring and screening of Schistosoma infections utilizing lateral-flow based assays and upconverting phosphor labels","volume":"141","author":"Corstjens","year":"2014","journal-title":"Parasitology"},{"key":"2020041015552391900_CIT0021","first-page":"CD000528","article-title":"Drugs for treating Schistosoma mansoni infection","volume":"2","author":"Danso-Appiah","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2020041015552391900_CIT0022","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.vetpar.2008.12.007","article-title":"Geometric means provide a biased efficacy result when conducting a faecal egg count reduction test (FECRT)","volume":"161","author":"Dobson","year":"2009","journal-title":"Vet Parasitol"},{"key":"2020041015552391900_CIT0023","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijpddr.2011.09.002","article-title":"Is anthelmintic resistance a concern for the control of human soil-transmitted helminths?","volume":"1","author":"Vercruysse","year":"2011","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"2020041015552391900_CIT0024","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.4269\/ajtmh.18-0671","article-title":"Comparison of the impact of different mass drug administration strategies on infection with Schistosoma mansoni in Mwanza Region, tanzania-a cluster-randomized controlled trial","volume":"99","author":"Olsen","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"2020041015552391900_CIT0025","doi-asserted-by":"crossref","first-page":"e0006033","DOI":"10.1371\/journal.pntd.0006033","article-title":"Cluster randomized trial comparing school-based mass drug administration schedules in areas of Western Kenya with moderate initial prevalence of Schistosoma mansoni infections","volume":"11","author":"Karanja","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"2020041015552391900_CIT0026","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.4269\/ajtmh.17-0368","article-title":"Defining persistent hotspots: areas that fail to decrease meaningfully in prevalence after multiple years of mass drug administration with praziquantel for control of schistosomiasis","volume":"97","author":"Kittur","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"2020041015552391900_CIT0027","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13071-016-1312-0","article-title":"New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel","volume":"9","author":"Walker","year":"2016","journal-title":"Parasit Vectors"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofaa091\/32899070\/ofaa091.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/7\/4\/ofaa091\/33034100\/ofaa091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/7\/4\/ofaa091\/33034100\/ofaa091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T20:00:51Z","timestamp":1586548851000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofaa091\/5804219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,12]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofaa091","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2020,3,12]]},"article-number":"ofaa091"}}