{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:22:13Z","timestamp":1784204533129,"version":"3.55.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Staphylococcus aureus bloodstream infection (SABSI) arising from a urinary tract source (UTS) is poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis in 3 major teaching hospitals in Spain of prospectively collected data of hospitalized patients with SABSI. SABSI-UTS was diagnosed in patients with urinary tract symptoms and\/or signs, no evidence of an extra-urinary source of infection, and a urinary S. aureus count of \u2265105\u2005cfu\/mL. Susceptibility of S. aureus strains and patient mortality were compared between SABSI from UTS (SABSI-UTS) and other sources (SABSI-other).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4181 episodes of SABSI, we identified 132 (3.16%) cases of SABSI-UTS that occurred predominantly in patients who were male, had high Charlson comorbidity scores, were dependent for daily life activities, and who had undergone urinary catheterization and\/or urinary manipulation before the infection. SABSI-UTS was more often caused by MRSA strains compared with SABSI-other (40.9% vs 17.5%; P &amp;lt; .001). Patients with SABSI-UTS caused by MRSA more often received inadequate empirical treatment compared with those caused by susceptible strains (59.7% vs 23.1%; P &amp;lt; .001). The 30-day case fatality rate was lower in patients with SABSI-UTS than in those with SABSI-other (14.4% vs 23.8%; P = .02). Factors independently associated with mortality were dependence for daily activities (aOR, 3.877; 95% CI, 1.08\u201313.8; P = .037) and persistent bacteremia (aOR, 7.88; 95% CI, 1.57\u201339.46; P = .012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SABSI-UTS occurs predominantly in patients with severe underlying conditions and in those who have undergone urinary tract manipulation. Moreover, it is frequently due to MRSA strains and causes significant mortality.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ofid\/ofaa216","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T09:30:44Z","timestamp":1591435844000},"source":"Crossref","is-referenced-by-count":14,"title":["Characteristics and Outcomes of Staphylococcus aureus Bloodstream Infection Originating From the Urinary Tract: A Multicenter Cohort Study"],"prefix":"10.1093","volume":"7","author":[{"given":"Sara","family":"Grillo","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Bellvitge University Hospital, Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-943X","authenticated-orcid":false,"given":"Guillermo","family":"Cuervo","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Bellvitge University Hospital, Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Carratal\u00e0","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Bellvitge University Hospital, Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"},{"name":"University of Barcelona (UB), Barcelona, 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University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Eduardo","family":"Lopez-Cort\u00e9s","sequence":"first","affiliation":[{"name":"Unidad Cl\u00ednica de Enfermedades Infecciosas, Microbiolog\u00eda y Medicina Preventiva, Hospital Universitario Virgen Macarena\/CSIC\/Departamento de Medicina, Universidad de Sevilla\/Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lalueza","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases, 12 de Octubre University Hospital, Madrid, Spain"},{"name":"Research Institute Hospital 12 de Octubre (I+12), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Sanjuan","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases, 12 de Octubre University Hospital, Madrid, Spain"},{"name":"Research Institute Hospital 12 de Octubre (I+12), Madrid, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sanchez-Batanero","sequence":"first","affiliation":[{"name":"Unidad Cl\u00ednica de Enfermedades Infecciosas, Microbiolog\u00eda y Medicina Preventiva, Hospital Universitario Virgen Macarena\/CSIC\/Departamento de Medicina, Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0225-607X","authenticated-orcid":false,"given":"Carmen","family":"Ardanuy","sequence":"first","affiliation":[{"name":"Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain"},{"name":"Department of Microbiology, Bellvitge University Hospital, Barcelona, Spain"},{"name":"CIBER of Respiratory Diseases, ISCIII, Madrid, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"},{"name":"Departmentos de Fundamentos Cl\u00ednicos and Patolog\u00eda y Terape\u00fatica Experimental, School of Medicine, of University of Barcelona (UB), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolors","family":"Garc\u00eda-Somoza","sequence":"first","affiliation":[{"name":"Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain"},{"name":"Department of Microbiology, Bellvitge University Hospital, Barcelona, Spain"},{"name":"CIBER of Respiratory Diseases, ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Teb\u00e9","sequence":"first","affiliation":[{"name":"Biostatistics Unit, Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, Spain"},{"name":"Basic Clinical Practice Department, Rovira Virgili University, Reus, 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