{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:40:42Z","timestamp":1785436842919,"version":"3.56.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Grant-a-Starr Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Universal HIV testing in adults presenting to a health care setting was recommended by the Centers for Disease Control and Prevention (CDC) in 2006, but compliance in central nervous system (CNS) infections is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A multicenter study of adults presenting with CNS infections to 18 hospitals in Houston and New Orleans between 2000 and 2015 was done to characterize HIV testing and explore factors associated with a positive HIV test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1478 patients with a diagnosis of meningitis or encephalitis were identified; 180 were excluded because of known HIV diagnosis (n = 100) or were &amp;lt;17 years old (n = 80). Out of 1292 patients, 642 (49.7%) had HIV testing, and testing did not differ significantly before or after the CDC recommendations in 2006 (53% vs 48%; P = .068). An HIV test was more commonly done in patients who were non-Caucasian, had fever &amp;gt;38\u00b0C, or had seizures on presentation, and of those tested, non-Caucasian patients and those with photophobia were more likely to have a positive HIV test (P &amp;lt; .05). HIV testing also varied by type of CNS infection: community-acquired bacterial meningitis (98\/130, 75.4%), encephalitis (174\/255, 68.2%), aseptic meningitis (285\/619, 46.0%), and health care\u2013associated meningitis (85\/288, 29.5%; P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Even though HIV testing should be done in all adults presenting with a CNS infection, testing remains ~50% and did not improve after the recommendation for universal testing by the CDC in 2006.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaa217","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T09:40:18Z","timestamp":1591436418000},"source":"Crossref","is-referenced-by-count":4,"title":["HIV Testing in Adults Presenting With Central Nervous System Infections"],"prefix":"10.1093","volume":"7","author":[{"given":"Bert","family":"Ma","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Texas (UT Health), McGovern Medical School, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J","family":"Vigil","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Texas (UT Health), McGovern Medical School, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Hasbun","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Texas (UT Health), McGovern Medical School, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,6]]},"reference":[{"key":"2020062716034744400_CIT0001","author":"Centers for Disease Control and Prevention","year":"2018"},{"key":"2020062716034744400_CIT0002","article-title":"Estimated HIV incidence and prevalence in the United States, 2010\u20132016","author":"Centers for Disease Control and Prevention","year":"2019"},{"key":"2020062716034744400_CIT0003","first-page":"1","article-title":"Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings","volume":"55","author":"Branson","year":"2006","journal-title":"MMWR Recomm Rep"},{"key":"2020062716034744400_CIT0004","doi-asserted-by":"crossref","first-page":"21579","DOI":"10.7448\/IAS.20.1.21579","article-title":"Clinical and public health implications of acute and early HIV detection and treatment: a scoping review","volume":"20","author":"Rutstein","year":"2017","journal-title":"J Int AIDS Soc"},{"key":"2020062716034744400_CIT0005","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1542\/peds.2012-2183KKKK","article-title":"Performance of HIV-1 DNA or HIV-1 RNA tests for early diagnosis of perinatal HIV-1 infection during anti-retroviral prophylaxis","volume":"130","author":"Church Joseph","year":"2012","journal-title":"Pediatrics"},{"key":"2020062716034744400_CIT0006","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1128\/JCM.05471-11","article-title":"Use of quantitative HIV RNA detection for early diagnosis of HIV infection in infants and acute HIV infections in Alberta, Canada","volume":"50","author":"Lee","year":"2012","journal-title":"J Clin Microbiol"},{"key":"2020062716034744400_CIT0007","first-page":"60","article-title":"Performance of HIV-1 DNA or HIV-1 RNA tests for early diagnosis of perinatal HIV-1 infection during anti-retroviral prophylaxis","volume":"2012; 160","author":"Burgard","journal-title":"J Pediatrics"},{"key":"2020062716034744400_CIT0008","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0140-6736(85)91205-X","article-title":"Acute AIDS retrovirus infection. 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