{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:59:48Z","timestamp":1790805588042,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Incarcerated persons are a special population with higher hepatitis C virus (HCV) prevalence and should be prioritized for micro-elimination. This study aimed to investigate the seroprevalence and to evaluate the effectiveness and safety of direct acting antiviral (DAA) therapy in the custodial settings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Incarcerated persons in Yunlin Prison were recruited to receive anti-HCV antibody screening. Patients with positive HCV ribonucleic acid (HCV RNA) were treated with glecaprevir\/pibrentasvir (GLE\/PIB) in our special chronic hepatitis C (CHC) clinic in prison. The primary endpoint was sustained virologic response at week 12 off therapy (SVR12).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1402 incarcerated persons were invited to anti-HCV screening and 824 (58.7%) accepted. The prevalence of anti-HCV positivity was 33.5% (276\/824) and the viremic rate (detectable HCV RNA) was 69.2% (191\/276). According to FIB-4 index, patients with F3 stage were six (3.1%), but none met the criteria of F4 stage. However, six (3.1%) had liver cirrhosis with splenomegaly, confirmed by findings of ultrasonography. The median log10 HCV RNA level at baseline was 6.235 (2.394-7.403). Genotype (GT) 6 was predominant (39.3%), followed by GT 1a (22.0%) and 1b (14.1%). Mixed genotype HCV infection accounted for 3.6% of total infections. In total, 165 patients received GLE\/PIB therapy. The overall SVR12 rates were 100%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>DAA therapy is highly effective and safe for incarcerated patients in Taiwan. Our special prison-based CHC clinic, linking universal screening to medical care, can serve as a model for micro-elimination of HCV in custodial settings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaa301","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T12:35:38Z","timestamp":1594989338000},"source":"Crossref","is-referenced-by-count":31,"title":["Micro-elimination of Chronic Hepatitis C by Universal Screening plus Direct Acting Antivirals for Incarcerated Persons in Taiwan"],"prefix":"10.1093","author":[{"given":"Tsung-Hua","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan"},{"name":"Hepatology Medical Center, National Taiwan University Hospital, Yunlin Branch, Douliu City, Yunlin County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jen","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan"},{"name":"Hepatology Medical Center, National Taiwan University Hospital, Yunlin Branch, Douliu City, Yunlin County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jer","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan"},{"name":"Hepatology Medical Center, National Taiwan University Hospital, Yunlin Branch, Douliu City, Yunlin County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Yuh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan"},{"name":"Hepatology Medical Center, National Taiwan University Hospital, Yunlin Branch, Douliu City, Yunlin County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Chin","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan"},{"name":"Hepatology Medical Center, National Taiwan University Hospital, Yunlin Branch, Douliu City, Yunlin County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jyun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan"},{"name":"Hepatology Medical Center, National Taiwan University Hospital, Yunlin Branch, Douliu City, Yunlin County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chi","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan"},{"name":"Hepatology Medical Center, National Taiwan University Hospital, Yunlin Branch, Douliu City, Yunlin County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan"},{"name":"Hepatology Medical Center, National Taiwan University Hospital, Yunlin Branch, Douliu City, Yunlin County, Taiwan"},{"name":"College of Medicine, National Taiwan University, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,17]]},"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofaa301\/33504985\/ofaa301.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofaa301\/33504985\/ofaa301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T12:35:38Z","timestamp":1594989338000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article\/doi\/10.1093\/ofid\/ofaa301\/5872670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofaa301","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,17]]},"article-number":"ofaa301"}}