{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:51:00Z","timestamp":1772639460991,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Planes Nacionales de I+D+i","award":["PI18\/01623"],"award-info":[{"award-number":["PI18\/01623"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR 18\/00048"],"award-info":[{"award-number":["JR 18\/00048"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM19\/00226"],"award-info":[{"award-number":["CM19\/00226"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa"},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Network for Research in Infectious Diseases","award":["RD16\/0016\/0002"],"award-info":[{"award-number":["RD16\/0016\/0002"]}]},{"name":"Spanish Network for Research in Infectious Diseases","award":["PI15\/02013"],"award-info":[{"award-number":["PI15\/02013"]}]},{"name":"European Development Regional Fund"},{"name":"Spanish Society of Infectious Diseases and Microbiology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Staphylococcus aureus is the leading cause of prosthetic joint infection (PJI). Beyond the antibiogram, little attention has been paid to the influence of deep microbiological characteristics on patient prognosis. Our aim was to investigate whether microbiological genotypic and phenotypic features have a significant influence on infection pathogenesis and patient outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective multicenter study was performed, including all S. aureus PJIs (2016\u20132017). Clinical data and phenotypic (agr functionality, \u03b2-hemolysis, biofilm formation) and genotypic characteristics of the strains were collected. Biofilm susceptibility to antimicrobials was investigated (minimal biofilm eradication concentration [MBEC] assay).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighty-eight patients (39.8% men, age 74.7\u2005\u00b1\u200514.1 years) were included. Forty-five had early postoperative infections (EPIs), 21 had chronic infections (CPIs), and 19 had hematogenous infections (HIs). Twenty (22.7%) were caused by methicillin-resistant S. aureus. High genotypic diversity was observed, including 16 clonal complexes (CCs), with CC5 being the most frequent (30.7%). agr activity was greater in EPI than CPI (55.6% vs 28.6%; P\u2005=\u2005.041). Strains causing EPI were phenotypically and genotypically similar, regardless of symptom duration. Treatment failure (36.5%) occurred less frequently among cases treated with implant removal. In cases treated with debridement and implant retention, there were fewer failures among those who received combination therapy with rifampin. No genotypic or phenotypic characteristics predicted failure, except vancomycin minimal inhibitory concentration \u22651.5 mg\/L (23.1% failure vs 3.4%; P\u2005=\u2005.044). MBEC50 was &amp;gt;128 mg\/L for all antibiotics tested and showed no association with prognosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>S. aureus with different genotypic backgrounds is capable of causing PJI, showing slight differences in clinical presentation and pathogenesis. No major microbiological characteristics were observed to influence the outcome, including MBEC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaa344","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T05:27:59Z","timestamp":1597382879000},"source":"Crossref","is-referenced-by-count":20,"title":["Genotypic and Phenotypic Characteristics of Staphylococcus aureus Prosthetic Joint Infections: Insight on the Pathogenesis and Prognosis of a Multicenter Prospective Cohort"],"prefix":"10.1093","volume":"7","author":[{"given":"Irene","family":"Mu\u00f1oz-Gallego","sequence":"first","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Viedma","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain"},{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Patolog\u00eda Infecciosa (REIPI), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovaci\u00f3n, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-3167","authenticated-orcid":false,"given":"Jaime","family":"Esteban","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikel","family":"Manche\u00f1o-Losa","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain"},{"name":"Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Garc\u00eda-Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna-Urgencias, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Blanco-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna-Urgencias, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Rico","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelaida","family":"Garc\u00eda-Perea","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Ruiz Garbajosa","sequence":"additional","affiliation":[{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Patolog\u00eda Infecciosa (REIPI), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovaci\u00f3n, Sevilla, Spain"},{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Escudero-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Patolog\u00eda Infecciosa (REIPI), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovaci\u00f3n, Sevilla, Spain"},{"name":"Servicio de 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Arana","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario de Getafe, Getafe, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Monereo","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario de Getafe, Getafe, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Domingo","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario de La Princesa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Cordero","sequence":"additional","affiliation":[{"name":"Servicio de Traumatolog\u00eda, Hospital Universitario de La Princesa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00aa Isabel","family":"S\u00e1nchez Romero","sequence":"additional","affiliation":[{"name":"Servicio de 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Chaves","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain"},{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Patolog\u00eda Infecciosa (REIPI), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovaci\u00f3n, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Grupo de Infecci\u00f3n Osteoarticular de la Comunidad de Madrid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal Parr\u00f3n","family":"Cambero","sequence":"additional","affiliation":[{"name":"Servicio de Traumatolog\u00eda y Cirug\u00eda Ortop\u00e9dica, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, 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