{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:28:34Z","timestamp":1759422514000,"version":"3.41.2"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T00:00:00Z","timestamp":1602979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a current pandemic worldwide. This virus can reach all organs and disturbs the immune system, leading to a cytokine storm in severe forms. We aimed to report cutaneous features among coronavirus disease 2019 (COVID-19) hospitalized patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a cross-sectional study on 1 given day among all patients hospitalized in acute care for COVID-19 and included all patients with cutaneous features. Follow-up 48 hours later was obtained.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 59 adult patients hospitalized on the day of the study in an infectious diseases ward for SARS-CoV-2 infection who were confirmed by molecular assay and\/or radiological findings (computed tomography scan), 40 were included. Several cutaneous manifestations were found: macular exanthema (80%), face edema (32%), livedo (13%), urticarial rash (8%), purpura (5%), oral lichenoid lesions (33%), and conjunctivitis (18%). Cutaneous biopsy was performed in 17 patients. Histological findings showed mast cell hyperplasia (100%), superficial perivascular infiltrate of lymphocytes (94%), and superficial edema (47%) consistent with capillary leak.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Various dermatological signs can be encountered during COVID-19. A macular rash was the most frequent. All cutaneous features could be related to a vascular leak process.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaa394","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T20:44:45Z","timestamp":1602967485000},"source":"Crossref","is-referenced-by-count":10,"title":["Clinical Cutaneous Features of Patients Infected With SARS-CoV-2 Hospitalized for Pneumonia: A Cross-sectional Study"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7218-3297","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Mascitti","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Bonsang","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy and Cytology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lien","family":"Dinh","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-6178","authenticated-orcid":false,"given":"Florence","family":"Assan","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Perronne","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibault","family":"Leblanc","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Duran","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Bouchand","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Matt","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Le Gal","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"N\u2019guyen Van Thanh","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aymeric","family":"Lanore","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, 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Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"de Truchis","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Landowski","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Davido","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Moreau","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Anne","family":"Rameix-Welti","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyanne","family":"Gault","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Laure","family":"Roux","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Sivadon-Tardy","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Salomon","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-2389","authenticated-orcid":false,"given":"Faten","family":"El Sayed","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Carlier","sequence":"additional","affiliation":[{"name":"Department of Radiology, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Emile","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy and Cytology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Perronne","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Raymond Poincar\u00e9 University Hospital, AP-HP Paris Saclay University, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Bourgault-Villada","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Immunology, Ambroise Par\u00e9 University Hospital, AP-HP Paris Saclay University, Boulogne-Billancourt, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,18]]},"reference":[{"author":"World Health Organization","key":"2020120402265894600_CIT0001"},{"key":"2020120402265894600_CIT0002"},{"key":"2020120402265894600_CIT0003","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S1473-3099(20)30200-0","article-title":"Clinical and virological data of the 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