{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T11:10:24Z","timestamp":1781953824355,"version":"3.54.5"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T00:00:00Z","timestamp":1599955200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated with significant morbidity and mortality. Severe dysregulated systemic inflammation is the putative mechanism. We hypothesize that early prolonged methylprednisolone (MP) treatment could accelerate disease resolution, decreasing the need for intensive care unit (ICU) admission and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter observational study to explore the association between exposure to prolonged, low-dose MP treatment and need for ICU referral, intubation, or death within 28 days (composite primary end point) in patients with severe COVID-19 pneumonia admitted to Italian respiratory high-dependency units. Secondary outcomes were invasive MV-free days and changes in C-reactive protein (CRP) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Findings are reported as MP (n\u2005=\u200583) vs control (n\u2005=\u200590). The composite primary end point was met by 19 vs 40 (adjusted hazard ratio [aHR], 0.41; 95% CI, 0.24\u20130.72). Transfer to ICU and invasive MV were necessary in 15 vs 27 (P\u2005=\u2005.07) and 14 vs 26 (P\u2005=\u2005.10), respectively. By day 28, the MP group had fewer deaths (6 vs 21; aHR, 0.29; 95% CI, 0.12\u20130.73) and more days off invasive MV (24.0\u2005\u00b1\u20059.0 vs 17.5\u2005\u00b1\u200512.8; P\u2005=\u2005.001). Study treatment was associated with rapid improvement in PaO2:FiO2 and CRP levels. The complication rate was similar for the 2 groups (P\u2005=\u2005.84).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with severe COVID-19 pneumonia, early administration of prolonged, low dose MP treatment was associated with a significantly lower hazard of death (71%) and decreased ventilator dependence. Treatment was safe and did not impact viral clearance. A large randomized controlled trial (RECOVERY trial) has been performed that validates these findings.<\/jats:p>\n                    <jats:p>Clinical trial registration.\u2003ClinicalTrials.gov NCT04323592.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaa421","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T04:54:06Z","timestamp":1599972846000},"source":"Crossref","is-referenced-by-count":97,"title":["Prolonged Low-Dose Methylprednisolone in Patients With Severe COVID-19 Pneumonia"],"prefix":"10.1093","volume":"7","author":[{"given":"Francesco","family":"Salton","sequence":"first","affiliation":[{"name":"Department of Pulmonology, University Hospital of Cattinara, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Confalonieri","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital of Cattinara, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Umberto","family":"Meduri","sequence":"additional","affiliation":[{"name":"Pulmonary, Critical Care, and Sleep Medicine Service and Research Service, Memphis VA Medical Center and Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierachille","family":"Santus","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences (DIBIC), Universit\u00e0 degli Studi di Milano, \u201cL. 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Spallanzani,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Vertui","sequence":"additional","affiliation":[{"name":"Pulmonology Unit, Policlinico San Matteo IRCCS, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiberio","family":"Oggionni","sequence":"additional","affiliation":[{"name":"Pulmonology Unit, Policlinico San Matteo IRCCS, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Caminati","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, San Giuseppe Hospital MultiMedica IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Patruno","sequence":"additional","affiliation":[{"name":"Pulmonology Department, S. Maria della Misericordia University Hospital, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Tamburrini","sequence":"additional","affiliation":[{"name":"S.C. 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