{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:39:19Z","timestamp":1762508359580,"version":"3.41.2"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR001856"],"award-info":[{"award-number":["KL2TR001856"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We implemented a preprocedural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening initiative designed to sustain health care during a time when the extent of SARS-CoV-2 infection was unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a prospective study of patients undergoing procedures at 3 academic hospitals in Pittsburgh, Pennsylvania (April 21\u2013June 11), and 19 community hospitals across Middle\/Western Pennsylvania and Southwestern New York (May 1\u2013June 11). Patients at academic hospitals underwent symptom screening \u22647 days preprocedure, then SARS-CoV-2 nasopharyngeal polymerase chain reaction (PCR) testing 1\u20134 days preprocedure. A subset also underwent day-of-procedure testing. Community hospital patients underwent testing per local protocols. We report SARS-CoV-2 PCR positivity rates, impact, and barriers to testing encountered through June 11. PCR positivity rates of optional preprocedural SARS-CoV-2 testing for 2 consecutive periods following the screening initiative are also reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 5881 eligible academic hospital patients, 2415 (41.1%) were tested (April 21\u2013June 11). Lack of interest, distance, self-isolation, and nursing home\/incarceration status were barriers. There were 11 PCR-positive patients (10 asymptomatic) among 10\u2005539 patients tested (0.10%; 95% CI, 0.05%\u20130.19%): 3\/2415 (0.12%; 95% CI, 0.02%\u20130.36%) and 8\/8124 (0.10%; 95% CI, 0.04%\u20130.19%) at academic and community hospitals, respectively. Procedures were performed as scheduled in 40% (4\/10) of asymptomatic PCR-positive patients. Positivity increased during subsequent coronavirus disease 2019 (COVID-19) surges: 54\/34\u2005948 (0.15%; 95% CI, 0.12%\u20130.20%) and 101\/24\u2005741 (0.41%; 95% CI, 0.33%\u20130.50%) PCR-positive patients from June 12\u2013September 10 and September 11\u2013December 15, respectively (P\u2005&amp;lt;\u2005.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Implementing preprocedural PCR testing was complex and revealed low infection rates (0.24% overall), which increased during COVID-19 surges. Additional studies are needed to define the COVID-19 prevalence threshold at which universal preprocedural screening is warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofab022","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T20:02:53Z","timestamp":1611000173000},"source":"Crossref","is-referenced-by-count":8,"title":["Preprocedural SARS-CoV-2 Testing to Sustain Medically Needed Health Care Delivery During the COVID-19 Pandemic: A Prospective Observational Study"],"prefix":"10.1093","volume":"8","author":[{"given":"Ghady","family":"Haidar","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"},{"name":"Division of Infectious Diseases, UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Ayres","sequence":"additional","affiliation":[{"name":"Division of Hospital Epidemiology and Infection Control, UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy C","family":"King","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackenzie","family":"McDonald","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew L","family":"Bilderback","sequence":"additional","affiliation":[{"name":"Wolff Center, UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tami","family":"Minnier","sequence":"additional","affiliation":[{"name":"Wolff Center, UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W","family":"Mellors","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"},{"name":"Division of Infectious Diseases, UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2021021217185690000_CIT0001","article-title":"Preserving elective surgeries in the COVID-19 pandemic and the 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