{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:55:12Z","timestamp":1790790912390,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"CIBER de Enfermedades Respiratorias","award":["CB06\/06\/0028"],"award-info":[{"award-number":["CB06\/06\/0028"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PI19\/00207"],"award-info":[{"award-number":["PI19\/00207"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Lymphopenia is a marker of poor prognosis in patients with community-acquired pneumonia (CAP), yet its impact on outcomes in patients with CAP and sepsis remains unknown. We aim to investigate the impact of lymphopenia on outcomes, risk of intensive care unit (ICU) admission, and mortality in CAP patients with sepsis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective, observational study of prospectively collected data from an 800-bed tertiary teaching hospital (2005\u20132019).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 2203 patients with CAP and sepsis, 1347 (61%) did not have lymphopenia, while 856 (39%) did. When compared with the nonlymphopenic group, patients with sepsis and lymphopenia more frequently required ICU admission (P\u2005=\u2005.001), had a longer hospital length of stay (P\u2005\u02c2\u2005.001), and presented with a higher rate of in-hospital (P \u02c2 .001) and 30-day mortality (P\u2005=\u2005.001). Multivariable analysis showed that C-reactive protein \u226515 mg\/dL, lymphopenia, pleural effusion, and acute respiratory distress syndrome within 24 hours of admission were risk factors for ICU admission; age \u226580 years was independently associated with decreased ICU admission. In addition, age \u226580 years, chronic renal disease, chronic neurologic disease, being a nursing home resident, lymphopenia, and pleural effusion were independently associated with increased 30-day mortality, whereas pneumococcal vaccination, diabetes mellitus, and fever were independently associated with reduced 30-day mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Lymphopenia was independently associated with risk of ICU admission and higher in-hospital and 30-day mortality in patients with CAP and sepsis. Early identification of lymphopenia could help identify septic patients with CAP who require or will shortly require critical care.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofab169","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T14:38:32Z","timestamp":1617719912000},"source":"Crossref","is-referenced-by-count":65,"title":["Lymphopenia Is Associated With Poor Outcomes of Patients With Community-Acquired Pneumonia and Sepsis"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4646-9838","authenticated-orcid":false,"given":"Catia","family":"Cilloniz","sequence":"first","affiliation":[{"name":"Department of Pneumology, Hospital Clinic of Barcelona, Barcelona, Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute\u2013IDIBAPS, University of Barcelona, Barcelona, Spain"},{"name":"Biomedical Research Networking Centres in Respiratory Diseases (Ciberes) Barcelona, 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