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On consultation with the infectious disease service, thorough history taking was performed that uncovered salient epidemiologic information pointing toward the eventual diagnosis of disseminated histoplasmosis. We discuss aspects of diagnosis and management, including the management of immune reconstitution syndrome which complicated treatment.<\/jats:p>","DOI":"10.1093\/ofid\/ofab280","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T19:01:53Z","timestamp":1622055713000},"source":"Crossref","is-referenced-by-count":1,"title":["Acute Liver Failure and Fever of Unknown Origin"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-7241","authenticated-orcid":false,"given":"Terry A","family":"Marryshow","sequence":"first","affiliation":[{"name":"Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P","family":"McQuillen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M","family":"Wener","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Morgan","family":"Freiman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"2021082709044788500_CIT0001","first-page":"157","article-title":"Histoplasma capsulatum: mechanisms for pathogenesis","volume":"422","author":"Mittal","year":"2019","journal-title":"Curr Top Microbiol 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