{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:21:34Z","timestamp":1779906094441,"version":"3.53.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20fk0108270h0001"],"award-info":[{"award-number":["20fk0108270h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Detailed differences in clinical information between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia (CP), which is the main phenotype of SARS-CoV-2 disease, and influenza pneumonia (IP) are still unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective, multicenter cohort study was conducted by including patients with CP who were hospitalized between January and June 2020 and a retrospective cohort of patients with IP hospitalized from 2009 to 2020. We compared the clinical presentations and studied the prognostic factors of CP and IP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with the IP group (n = 66), in the multivariate analysis, the CP group (n = 362) had a lower percentage of patients with underlying asthma or chronic obstructive pulmonary disease (P &amp;lt; .01), lower neutrophil-to-lymphocyte ratio (P &amp;lt; .01), lower systolic blood pressure (P &amp;lt; .01), higher diastolic blood pressure (P &amp;lt; .01), lower aspartate aminotransferase level (P &amp;lt; .05), higher serum sodium level (P &amp;lt; .05), and more frequent multilobar infiltrates (P &amp;lt; .05). The diagnostic scoring system based on these findings showed excellent differentiation between CP and IP (area under the receiver operating characteristic curve, 0.889). Moreover, the prognostic predictors were different between CP and IP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Comprehensive differences between CP and IP were revealed, highlighting the need for early differentiation between these 2 pneumonias in clinical settings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofab282","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T18:29:52Z","timestamp":1622312992000},"source":"Crossref","is-referenced-by-count":3,"title":["Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study"],"prefix":"10.1093","volume":"8","author":[{"given":"Issei","family":"Oi","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan"},{"name":"Department of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Obama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan"},{"name":"Department of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Obama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Hirabayashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Emura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Kyoto City Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Fukui Prefectural Hospital, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitokazu","family":"Tsukao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Fukui Prefectural Hospital, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Tomii","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, 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