{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:54:45Z","timestamp":1789631685235,"version":"build-2803163510"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Histoplasma capsulatum is a rare cause of fungal endocarditis that affects both native and prosthetic valves. It is associated with a high mortality rate if not diagnosed early and treated with a combination of antifungal therapy and surgical intervention. We present a case of a 47-year-old man with histoplasmosis infective endocarditis. He was successfully treated with antifungal therapy and surgical replacement of the infected bioprosthetic aortic valve. Our systemic literature review includes 52 articles encompassing 60 individual cases of H. capsulatum infective endocarditis from 1940 to 2020. Patient presentations, diagnostic laboratory testing accuracy, treatment modalities, and patient outcomes comparing and contrasting native and prosthetic valve infection are described.<\/jats:p>","DOI":"10.1093\/ofid\/ofab360","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T15:41:33Z","timestamp":1626277293000},"source":"Crossref","is-referenced-by-count":17,"title":["Native vs Prosthetic Valve <i>Histoplasma capsulatum<\/i> Infective Endocarditis: A Case Report and Systemic Literature Review Comparing Patient Presentation, Treatment Modalities, Clinical Outcomes, and Diagnostic Laboratory Testing"],"prefix":"10.1093","volume":"8","author":[{"suffix":"Jr.","given":"Bobby L","family":"Boyanton","sequence":"first","affiliation":[{"name":"Department of Pathology, Arkansas Children\u2019s Hospital, Little Rock, Arkansas, USA"},{"name":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Boamah","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Western Michigan School of Medicine, Kalamazoo, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl B","family":"Lauter","sequence":"additional","affiliation":[{"name":"Sections of Infectious Diseases, Allergy and Immunology, Department of Medicine, Beaumont Hospital, Royal Oak, Michigan, USA"},{"name":"Department of Medicine, Oakland University William Beaumont School of Medicine, Rochester Hills, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"2021080916404296400_CIT0001","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s11046-020-00431-2","article-title":"Re-drawing the maps for endemic mycoses","volume":"185","author":"Ashraf","year":"2020","journal-title":"Mycopathologia"},{"key":"2021080916404296400_CIT0002","doi-asserted-by":"crossref","first-page":"902\u201318","DOI":"10.1001\/archinte.1940.00190110031004","article-title":"Reticuloendothelial cytomycosis (histoplasmosis of darling)","volume":"65","author":"Humphrey","year":"1940","journal-title":"Arch Intern Med"},{"key":"2021080916404296400_CIT0003","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jama.1943.02840250013003","article-title":"Histoplasmosis producing vegetative endocarditis: review of literature, with report of a case","volume":"122","author":"Broders","year":"1943","journal-title":"JAMA"},{"key":"2021080916404296400_CIT0004","first-page":"251","article-title":"Case reports of Barnes Hospital","volume":"40","author":"Wood","year":"1943","journal-title":"J Mo State Med Assoc"},{"key":"2021080916404296400_CIT0005","first-page":"167","article-title":"Histoplasmosis: report of a case","volume":"2","author":"Kemper","year":"1944","journal-title":"J Oral Surg"},{"key":"2021080916404296400_CIT0006","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0002-8703(45)90602-8","article-title":"Vegetative endocarditis caused by higher bacteria and fungi: review of previous cases and report of two cases with autopsies","volume":"29","author":"Beamer","year":"1945","journal-title":"Am Heart J"},{"key":"2021080916404296400_CIT0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archinte.1945.00210250008001","article-title":"Histoplasmosis in man: report of seven cases and a review of 71 cases","volume":"75","author":"Parsons","year":"1945","journal-title":"Arch Intern Med"},{"key":"2021080916404296400_CIT0008","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3949\/ccjm.18.4.305","article-title":"Vegetative endocarditis due to Histoplasma capsulatum; 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