{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:29:45Z","timestamp":1765960185707,"version":"3.41.2"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011054","name":"Danish International Development Agency","doi-asserted-by":"publisher","award":["17-02-KU"],"award-info":[{"award-number":["17-02-KU"]}],"id":[{"id":"10.13039\/501100011054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Independent Research Fund","award":["0134-00123B"],"award-info":[{"award-number":["0134-00123B"]}]},{"name":"Consultative Committee for Development Research","award":["BSU3-UG"],"award-info":[{"award-number":["BSU3-UG"]}]},{"name":"European 7th Framework Programme","award":["200889"],"award-info":[{"award-number":["200889"]}]},{"DOI":"10.13039\/100012947","name":"Institut de Recherche pour le D\u00e9veloppement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Sickle cell trait (HbAS) protects against severe Plasmodium falciparum malaria but not against placental malaria (PM). In this study, P falciparum erythrocyte membrane protein (PfEMP1)-specific antibodies were measured in HbAA and HbAS Beninese pregnant women as a proxy of exposure to specific PfEMP1 variants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Plasma samples collected at delivery from 338 HbAA and 63 HbAS women were used to measure immunoglobulin (Ig)G levels to 6 recombinant PfEMP1 proteins and 3 corresponding native proteins expressed on the infected erythrocyte (IE) surface. Immunoglobulin G-mediated inhibition of VAR2CSA+ IEs adhesion to chondroitin sulfate A (CSA) was also tested.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Levels of PfEMP1-specific IgG were similar in the 2 groups, except for native IT4VAR09 on IEs, where IgG levels were significantly higher in HbAS women. Adjusted odds ratios for women with positive IgG to HB3VAR06 and PFD1235w suggest a lower risk of infection with these virulent variants among HbAS individuals. The percentage of IEs binding to CSA did not differ between HbAA and HbAS women, but it correlated positively with levels of anti-VAR2CSA and parity. Women with PM had lower levels of anti-VAR2CSA-specific IgG and lower IgG-mediated inhibition of IE adhesion to CSA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The findings support similar malaria exposure in HbAA and HbAS women and a lack of HbAS-dependent protection against placental infection among pregnant women.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofab527","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T04:10:26Z","timestamp":1637208626000},"source":"Crossref","is-referenced-by-count":8,"title":["PfEMP1-Specific Immunoglobulin G Reactivity Among Beninese Pregnant Women With Sickle Cell Trait"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-0248","authenticated-orcid":false,"given":"Mary","family":"Lopez-Perez","sequence":"first","affiliation":[{"name":"Centre for Medical 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University of Ghana, Accra, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja T R","family":"Jensen","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Doritchamou","sequence":"additional","affiliation":[{"name":"Institut de Recherche Clinique du Benin, Abomey Calavi, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicaise Tuikue","family":"Ndam","sequence":"additional","affiliation":[{"name":"UMR 261 MERIT, Universit\u00e9 de Paris, Institut de Recherche pour le D\u00e9veloppement, Paris, France"},{"name":"Institut de Recherche Clinique du Benin, Abomey Calavi, Benin"},{"name":"Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-4927","authenticated-orcid":false,"given":"Lars","family":"Hviid","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Centre for Medical Parasitology, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"2021121102240022600_CIT0001","doi-asserted-by":"crossref","first-page":"299","DOI":"10.30875\/60123dd4-en","volume-title":"World Malaria Report 2020: 20 Years of Global Progress and Challenges","author":"World Health 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