{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:30:58Z","timestamp":1791945058213,"version":"4.3.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Atrius Health implemented a best practice alert (BPA) to encourage clinicians to provide expedited partner therapy (EPT) in October 2014. We assessed (1) the impact of the BPA on EPT provision and chlamydial reinfection and (2) the impact of EPT on testing for chlamydia reinfection and reinfection rates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included patients\u2005\u226515 years with\u2005\u22651 positive chlamydia test between January 2013 and March 2019. Tests-of-reinfection were defined as chlamydia tests 28\u2013120 days after initial infection, and corresponding positive results were considered evidence of reinfection. We used interrupted time series analyses to identify changes in (1) frequency of EPT, (2) tests-of-reinfection, and (3) reinfections after the BPA was released. Log-binomial regression models, with generalized estimating equation methods, assessed associations between (1) EPT and tests-of-reinfection and (2) EPT and reinfection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 7267 chlamydia infections, EPT was given to 1475 (20%) patients. Expedited partner therapy frequency increased from 15% to 22% of infections between January 2013 and September 2014 (\u03b2\u2005=\u20050.003, P\u2005=\u2005.03). After the BPA was released, EPT frequency declined to 19% of infections by March 2019 (\u03b2\u2005=\u2005\u22120.004, P\u2005=\u2005.008). On average, 35% of chlamydia infections received a test-of-reinfection and 7% were reinfected; there were no significant changes in these percentages after BPA implementation. Patients given EPT were more likely to receive tests-of-reinfection (prevalence ratio [PR] 1.09; 95% confidence interval [CI], 1.01\u20131.16) but without change in reinfections (PR 0.88; 95% CI, 0.66\u20131.17).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Best practice alerts in electronic medical record systems may not be effective at increasing EPT prescribing and decreasing chlamydial reinfection. However, patients given EPT were more likely to receive a test of chlamydia reinfection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofab574","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T05:59:22Z","timestamp":1637215162000},"source":"Crossref","is-referenced-by-count":4,"title":["Impact of an Electronic Medical Record Best Practice Alert on Expedited Partner Therapy for Chlamydia Infection and Reinfection"],"prefix":"10.1093","volume":"9","author":[{"given":"Sarah J","family":"Willis","sequence":"first","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA"},{"name":"Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Elder","sequence":"additional","affiliation":[{"name":"Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelle M","family":"Cocoros","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myfanwy","family":"Callahan","sequence":"additional","affiliation":[{"name":"Atrius Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine K","family":"Hsu","sequence":"additional","affiliation":[{"name":"Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Klompas","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA"},{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"2022010923090612700_CIT0001","volume-title":"Sexually transmitted disease surveillance 2018","author":"Centers for Disease Control and Prevention.","year":"2019"},{"key":"2022010923090612700_CIT0002","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/OLQ.0b013e31815c11fe","article-title":"Chlamydia trachomatis reinfection rates among female adolescents seeking rescreening in school-based health centers.","volume":"35","author":"Gaydos","year":"2008","journal-title":"Sex Transm Dis"},{"key":"2022010923090612700_CIT0003","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1136\/sti.2006.024059","article-title":"Chlamydial and gonococcal reinfection among men: a systematic review of data to evaluate the need for retesting.","volume":"83","author":"Fung","year":"2007","journal-title":"Sex Transm Infect"},{"key":"2022010923090612700_CIT0004","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/OLQ.0b013e3181a2a933","article-title":"Repeat infection with Chlamydia and gonorrhea among females: a systematic review of the literature.","volume":"36","author":"Hosenfeld","year":"2009","journal-title":"Sex Transm Dis"},{"key":"2022010923090612700_CIT0005","volume-title":"Expedited partner therapy in the management of sexually transmitted diseases","author":"Centers for Disease Control and Prevention.","year":"2006"},{"key":"2022010923090612700_CIT0006","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1056\/NEJMoa041681","article-title":"Effect of expedited treatment of sex partners on recurrent or persistent gonorrhea or chlamydial infection.","volume":"352","author":"Golden","year":"2005","journal-title":"N Engl J Med"},{"key":"2022010923090612700_CIT0007","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1086\/432476","article-title":"Patient delivered partner treatment for male urethritis: a randomized, controlled trial.","volume":"41","author":"Kissinger","year":"2005","journal-title":"Clin Infect Dis"},{"key":"2022010923090612700_CIT0008","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00007435-200301000-00011","article-title":"Patient-delivered partner treatment with azithromycin to prevent repeated Chlamydia trachomatis infection among women: a randomized, controlled 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American College of Obstetricians and Gynecologists.","volume":"131","author":"Expedited partner therapy.","year":"2018","journal-title":"Obstet Gynecol"},{"key":"2022010923090612700_CIT0021","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/0009922814559379","article-title":"Real-time electronic medical record alerts increase high blood pressure recognition in children.","volume":"54","author":"Brady","year":"2015","journal-title":"Clin Pediatr (Phila)"},{"key":"2022010923090612700_CIT0022","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1002\/hep.29362","article-title":"Impact of an electronic health record alert in primary care on increasing hepatitis c screening and curative treatment for baby boomers.","volume":"66","author":"Konerman","year":"2017","journal-title":"Hepatology"},{"key":"2022010923090612700_CIT0023","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12911-017-0430-8","article-title":"Effects of workload, work complexity, and repeated alerts on alert fatigue in a clinical decision support system.","volume":"17","author":"Ancker","year":"2017","journal-title":"BMC Med Inform Decis Mak"},{"key":"2022010923090612700_CIT0024","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1089\/jwh.2018.7352","article-title":"Female sexual health: barriers to optimal outcomes and a roadmap for improved patient-clinician communications.","volume":"28","author":"Kingsberg","year":"2019","journal-title":"J Womens Health (Larchmt)"},{"key":"2022010923090612700_CIT0025","doi-asserted-by":"crossref","DOI":"10.1097\/OLQ.0000000000001337","article-title":"Who\u2019s practicing expedited partner therapy and why? Insights from providers working in high STI-volume specialties.","author":"McCool-Myers","year":"2020","journal-title":"Sex Transm Dis"},{"key":"2022010923090612700_CIT0026","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1331\/JAPhA.2010.09001","article-title":"Privacy in the pharmacy environment: analysis of observations from inside the pharmacy.","volume":"50","author":"Bednarczyk","year":"2010","journal-title":"J Am Pharm Assoc (2003)"},{"key":"2022010923090612700_CIT0027","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/OLQ.0000000000000751","article-title":"Expedited partner therapy: pharmacist refusal of legal prescriptions.","volume":"45","author":"Borchardt","year":"2018","journal-title":"Sex Transm Dis"},{"key":"2022010923090612700_CIT0028","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1097\/OLQ.0000000000000399","article-title":"The expedited partner therapy continuum: a conceptual framework to guide programmatic efforts to increase partner treatment.","volume":"43","author":"Schillinger","year":"2016","journal-title":"Sex Transm Dis"},{"key":"2022010923090612700_CIT0029","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/OLQ.0000000000001163","article-title":"Do prescriptions for expedited partner therapy for chlamydia get filled? Findings from a multi-jurisdictional evaluation, United States, 2017-2019.","volume":"47","author":"Slutsker","year":"2020","journal-title":"Sex Transm Dis"},{"key":"2022010923090612700_CIT0030","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/sextrans-2017-053161","article-title":"Detection of Chlamydia trachomatis in rectal specimens in women and its association with anal intercourse: a systematic review and meta-analysis.","volume":"94","author":"Chandra","year":"2018","journal-title":"Sex Transm Infect"},{"key":"2022010923090612700_CIT0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021.","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofab574\/41158558\/ofab574.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/9\/1\/ofab574\/42092587\/ofab574.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/9\/1\/ofab574\/42092587\/ofab574.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T23:25:50Z","timestamp":1641770750000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofab574\/6429316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,16]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofab574","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,11,16]]},"article-number":"ofab574"}}