{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:33:31Z","timestamp":1792794811679,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hereaus Medical"},{"name":"John Hunter Hospital","id":[{"id":"https:\/\/ror.org\/0187t0j49","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Periprosthetic joint infection (PJI) is a devastating condition and there is a lack of evidence to guide its management. We hypothesized that treatment success is independently associated with modifiable variables in surgical and antibiotic management.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The is a prospective, observational study at 27 hospitals across Australia and New Zealand. Newly diagnosed large joint PJIs were eligible. Data were collected at baseline and at 3, 12, and 24 months. The main outcome measures at 24 months were clinical cure (defined as all of the following: alive, absence of clinical or microbiological evidence of infection, and not requiring ongoing antibiotic therapy) and treatment success (clinical cure plus index prosthesis still in place).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Twenty-four-month outcome data were available for 653 patients. Overall, 449 patients (69%) experienced clinical cure and 350 (54%) had treatment success. The most common treatment strategy was debridement and implant retention (DAIR), with success rates highest in early postimplant infections (119 of 160, 74%) and lower in late acute (132 of 267, 49%) and chronic (63 of 142, 44%) infections. Selected comorbidities, knee joint, and Staphylococcus aureus infections were independently associated with treatment failure, but antibiotic choice and duration (including rifampicin use) and extent of debridement were not.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Treatment success in PJI is associated with (1) selecting the appropriate treatment strategy and (2) nonmodifiable patient and infection factors. Interdisciplinary decision making that matches an individual patient to an appropriate management strategy is a critical step for PJI management. Randomized controlled trials are needed to determine the role of rifampicin in patients managed with DAIR and the optimal surgical strategy for late-acute PJI.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ofid\/ofac048","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T14:25:53Z","timestamp":1644330353000},"source":"Crossref","is-referenced-by-count":61,"title":["Predictors of Treatment Success After Periprosthetic Joint Infection: 24-Month Follow up From a Multicenter Prospective Observational Cohort Study of 653 Patients"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-5699","authenticated-orcid":false,"given":"Joshua S","family":"Davis","sequence":"first","affiliation":[{"name":"Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia"},{"name":"Department of Infectious Diseases, John Hunter Hospital, Newcastle, New South Wales, Australia"},{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Metcalf","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Christchurch Hospital, Christchurch, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Owen","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"College of Science, Health, Engineering and Education, Discipline of Health, Murdoch University, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Huggan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Waikato Hospital, Hamilton, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Luey","sequence":"additional","affiliation":[{"name":"Counties Manukau District Health Board, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"McBride","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Northern Health, Epping, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Aboltins","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Northern Health, Epping, Melbourne, Victoria, Australia"},{"name":"Northern Clinical School, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjy","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Wakefield Orthopaedic Clinic and The University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Bogdan","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma, Royal Adelaide Hospital and The University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R","family":"Loewenthal","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, John Hunter Hospital, Newcastle, New South Wales, Australia"},{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piers","family":"Yates","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"},{"name":"Medical School, University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Athan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Barwon Health, Deakin University, Geelong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcie","family":"Cooper","sequence":"additional","affiliation":[{"name":"Geelong Centre for Emerging Infectious Disease, Deakin University, Geelong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Rad","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Barwon Health, Deakin University, Geelong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Allworth","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St Vincent\u2019s Private Hospital Northside, Chermside, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Wollongong Hospital, Wollongong, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Read","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, North Shore Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases, Royal Hobart Hospital, Hobart, Tasmania, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Sud","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nepean Hospital, Kingswood, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vana","family":"Nagendra","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Liverpool Hospital, Liverpool, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Chean","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Latrobe Regional Hospital, Traralgon, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Lemoh","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Dandenong Hospital, Dandenong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Mutalima","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Dandenong Hospital, Dandenong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Dandenong Hospital, Dandenong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Grimwade","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Tauranga Hospital, Tauranga, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjoree","family":"Sehu","sequence":"additional","affiliation":[{"name":"Infection Management Services, Princess Alexandra Hospital, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Looke","sequence":"additional","affiliation":[{"name":"Infection Management Services, Princess Alexandra Hospital, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Torda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, UNSW Sydney, Randwick, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi","family":"Aung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Redcliffe, Hospital, Redcliffe, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Graves","sequence":"additional","affiliation":[{"name":"Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, South Australia, Australia"},{"name":"School of Surgery, University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Paterson","sequence":"additional","affiliation":[{"name":"UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-5351","authenticated-orcid":false,"given":"Laurens","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"},{"name":"Medical School, University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"2022022709385641400_CIT0001","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.arth.2009.04.027","article-title":"Prosthetic joint infection risk after total hip arthroplasty in the Medicare population.","volume":"24","author":"Ong","year":"2009","journal-title":"J Arthroplasty"},{"key":"2022022709385641400_CIT0002","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11999-009-1013-5","article-title":"Prosthetic joint 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A 10-year follow-up from Sweden.","author":"Wildeman","year":"2021","journal-title":"Clin Orthop Relat Res"},{"key":"2022022709385641400_CIT0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.arth.2012.02.022","article-title":"Economic burden of periprosthetic joint infection in the United States.","volume":"27","author":"Kurtz","year":"2012","journal-title":"J Arthroplasty"},{"key":"2022022709385641400_CIT0006","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1469-0691.2011.03758.x","article-title":"Cost analysis of debridement and retention for management of prosthetic joint infection.","volume":"19","author":"Peel","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"2022022709385641400_CIT0007","doi-asserted-by":"crossref","first-page":"S399","DOI":"10.1016\/j.arth.2018.09.025","article-title":"Hip and knee section, treatment, debridement and retention of implant: Proceedings of International Consensus on Orthopedic 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Dis"},{"key":"2022022709385641400_CIT0014","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/cis803","article-title":"Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America.","volume":"56","author":"Osmon","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2022022709385641400_CIT0015","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1007\/s11999-013-2866-1","article-title":"Success after treatment of periprosthetic joint infection: a Delphi-based international multidisciplinary consensus.","volume":"471","author":"Diaz-Ledezma","year":"2013","journal-title":"Clin Orthop Relat Res"},{"key":"2022022709385641400_CIT0016","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/j.1469-0691.2010.03157.x","article-title":"Acute haematogenous prosthetic joint infection: prospective evaluation of medical and surgical 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