{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:34:19Z","timestamp":1769916859147,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["110-T07"],"award-info":[{"award-number":["110-T07"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Controlling latent tuberculosis infection (LTBI) is important in eliminating tuberculosis (TB); however, the prevalence of LTBI has rarely been studied in patients with nontuberculous mycobacterial (NTM) lung disease (LD) and colonization (LC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We prospectively recruited subjects with NTM isolated from sputum mycobacterial cultures from December 2011 to June 2019. NTM-LD and NTM-LC were defined according to the American Thoracic Society guidelines. Patients with negative cultures were recruited as controls. Patients with a history of active TB or positive TB cultures were excluded. LTBI was confirmed using a QuantiFERON-TB Gold In-tube test. The prevalence and factors associated with LTBI were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 406 participants were enrolled, including 171 in the NTM-LD group, 153 in the NTM-LC group, and 82 in the control group. The prevalence of LTBI was higher in the NTM-LD and NTM-LC groups than in the controls (21.6%, 20.9%, and 6.1%; P\u2005=\u2005.006). Multivariable analysis showed that old age (adjusted odds ratio [aOR], 1.021, per year increment; P\u2005=\u2005.042), NTM-LD (aOR, 4.030; P\u2005=\u2005.005), NTM-LC (aOR, 3.610; P\u2005=\u2005.011, compared with the controls), and pulmonary cavitary lesions (aOR, 3.393; P\u2005=\u2005.034) were independently associated with LTBI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The prevalence of LTBI was higher in the patients with NTM-LD and NTM-LC than in the controls. Old age, pulmonary cavitation, and NTM isolated from sputum were associated with a higher risk of LTBI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofac072","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T11:14:26Z","timestamp":1644405266000},"source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of Latent Tuberculous Infection in Patients With Nontuberculous Mycobacterial Lung Disease and Colonization: A Prospective Study in an Intermediate Tuberculosis Burden Country"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-8670","authenticated-orcid":false,"given":"Ho-Sheng","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital, Kaohsiung City, Taiwan"},{"name":"School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6380-3527","authenticated-orcid":false,"given":"Yu-Feng","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung City, Taiwan"},{"name":"Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Jung","family":"Tsai","sequence":"additional","affiliation":[{"name":"College of Medicine, I-Shou University, Kaohsiung City, Taiwan"},{"name":"Department of Medical Research, E-Da Hospital, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0304-4258","authenticated-orcid":false,"given":"Ping-Huai","family":"Wang","sequence":"additional","affiliation":[{"name":"Far Eastern Memorial Hospital, New Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University, Hospital Yun-Lin Branch, Douliu City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Wei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chung","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei City, 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