{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:25:31Z","timestamp":1784366731771,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Mycobacterium marinum is a nontuberculous mycobacterium that causes skin and soft tissue infections. Treatment consists of multiple antibiotics, sometimes combined with surgical debridement. There is little evidence for the choice of antibiotics, the duration of treatment, and the role of susceptibility testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a retrospective cohort study of culture-confirmed M. marinum infections in the Netherlands in the 2011\u20132018 period. Clinical characteristics, in vitro susceptibility, extent of disease, treatment regimens, and outcomes were analyzed. Incidence was assessed from laboratory databases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty cases of M. marinum infection could be studied. Antibiotic treatment cured 36\/40 patients (90%) after a mean treatment duration of 25 weeks. Failure\/relapse occurred in 3 patients, and 1 patient was lost to follow-up. Antibiotic treatment consisted of monotherapy in 35% and 2-drug therapy in 63%. Final treatment contained mostly ethambutol\u2013macrolide combinations (35%). Eleven patients (28%) received additional surgery. We recorded high rates of in vitro resistance to tetracyclines (36% of isolates). Tetracycline resistance seemed correlated with poor response to tetracycline monotherapy. The annual incidence rate was 0.15\/100\u2005000\/year during the study period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Prolonged and susceptibility-guided treatment results in a 90% cure rate in M. marinum disease. Two-drug regimens of ethambutol and a macrolide are effective for moderately severe infections. Tetracycline monotherapy in limited disease should be used vigilantly, preferably with proven in vitro susceptibility.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofac077","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T15:30:51Z","timestamp":1647444651000},"source":"Crossref","is-referenced-by-count":25,"title":["Treatment and Outcome of Culture-Confirmed <i>Mycobacterium marinum<\/i> Disease"],"prefix":"10.1093","volume":"9","author":[{"given":"Louise","family":"Hendrikx","sequence":"first","affiliation":[{"name":"Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Radboudumc Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette L M","family":"van Hees","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-156X","authenticated-orcid":false,"given":"Jurriaan E M","family":"de Steenwinkel","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannelore I","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Sprong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Canisius Wilhelmine Hospital, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Canisius Wilhelmine Hospital, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Jansz","sequence":"additional","affiliation":[{"name":"PAMM Laboratory of Medical Microbiology, Veldhoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjanne","family":"van Griethuysen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Gelderse Vallei Hospital, Ede, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Bosboom","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Rijnstate Hospital, Arnhem, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Stemerding","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Gelre Hospital, Apeldoorn, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"Koetsier","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gelre Hospital, Apeldoorn, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"van Coevorden","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gelre Hospital, Apeldoorn, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas C","family":"Mourik","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen D","family":"Quint","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alewijn","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Certe, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"van Soolingen","sequence":"additional","affiliation":[{"name":"Tuberculosis Reference Laboratory, National Institute for Public Health and the Environment, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Kuipers","sequence":"additional","affiliation":[{"name":"Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinout","family":"van Crevel","sequence":"additional","affiliation":[{"name":"Radboudumc Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-2003","authenticated-orcid":false,"given":"Jakko","family":"van Ingen","sequence":"additional","affiliation":[{"name":"Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"2022031615304621600_CIT0001","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1086\/313972","article-title":"Incubation period and sources of exposure for cutaneous Mycobacterium marinum infection: case report and review of the 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