{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:12:14Z","timestamp":1784801534673,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We herein present the case of a 28-year-old male patient who presented with fever and bilateral upper eyelid edema without other upper airway symptoms and was diagnosed with acute dacryoadenitis due to Epstein-Barr virus (EBV) infection. The patient\u2019s medical history was unremarkable. Laboratory tests revealed lymphocytosis with atypical lymphocytes and abnormal liver function tests. Physical examination and computed tomography revealed swelling in the lacrimal glands, and serological tests confirmed EBV infection. Although rare, ocular symptoms of primary EBV infection are important for diagnosis. Acute dacryoadenitis should be considered as a rare manifestation and an underdiagnosed complication of primary EBV infection.<\/jats:p>","DOI":"10.1093\/ofid\/ofac086","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T15:21:05Z","timestamp":1645543265000},"source":"Crossref","is-referenced-by-count":7,"title":["Acute Dacryoadenitis due to Primary Epstein-Barr Virus Infection"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3554-1600","authenticated-orcid":false,"given":"Satoshi","family":"Hayano","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruhiko","family":"Nakada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kashima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"2022032913362614000_CIT0001","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1056\/NEJMcp1001116","article-title":"Infectious mononucleosis.","volume":"362","author":"Luzuriaga","year":"2010","journal-title":"N Engl J Med"},{"key":"2022032913362614000_CIT0002","doi-asserted-by":"crossref","first-page":"h1825","DOI":"10.1136\/bmj.h1825","article-title":"Infectious mononucleosis.","volume":"350","author":"Lennon","year":"2015","journal-title":"BMJ"},{"key":"2022032913362614000_CIT0003","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12875-019-0954-3","article-title":"Epstein-Barr virus and its association with disease - a review of relevance to general practice.","volume":"20","author":"Fugl","year":"2019","journal-title":"BMC Fam Pract"},{"key":"2022032913362614000_CIT0004","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0002-9394(99)00351-7","article-title":"Epstein-Barr virus dacryoadenitis.","volume":"129","author":"Rhem","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"2022032913362614000_CIT0005","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0002-9394(01)01182-5","article-title":"Epstein-Barr virus dacryoadenitis resulting in keratoconjunctivitis sicca in a child.","volume":"132","author":"Merayo-Lloves","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"2022032913362614000_CIT0006","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1034\/j.1600-0420.2002.800323.x","article-title":"Acute infectious mononucleosis presenting with dacryoadenitis and tonsillitis.","volume":"80","author":"Marchese-Ragona","year":"2002","journal-title":"Acta Ophthalmol Scand"},{"key":"2022032913362614000_CIT0007","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0039-6257(90)90069-8","article-title":"Ocular disease associated with Epstein-Barr virus infection.","volume":"35","author":"Matoba","year":"1990","journal-title":"Surv Ophthalmol"},{"key":"2022032913362614000_CIT0008","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/01676830.2011.584933","article-title":"Acute dacryocystitis associated with Epstein-Barr virus infection.","volume":"30","author":"Ghauri","year":"2011","journal-title":"Orbit"},{"key":"2022032913362614000_CIT0009","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0002-9343(52)90154-X","article-title":"Infectious mononucleosis.","volume":"13","author":"Hoagland","year":"1952","journal-title":"Am J Med"},{"key":"2022032913362614000_CIT0010","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.jiac.2020.06.009","article-title":"Sex difference in clinical presentation of patients with infectious mononucleosis caused by Epstein-Barr virus.","volume":"26","author":"Sasaki","year":"2020","journal-title":"J Infect Chemother"},{"key":"2022032913362614000_CIT0011","doi-asserted-by":"crossref","first-page":"030006052092455300060520924550","DOI":"10.1177\/0300060520924550","article-title":"Clinical manifestations and laboratory results of 61 children with infectious mononucleosis.","volume":"48","author":"Wu","year":"2020","journal-title":"J Int Med Res"},{"key":"2022032913362614000_CIT0012","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s15010-013-0487-y","article-title":"Three cases of primary EBV infection in young adults manifested by periorbital and eyelid oedema.","volume":"41","author":"Demonchy","year":"2013","journal-title":"Infection"},{"key":"2022032913362614000_CIT0013","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0002-9343(51)90106-4","article-title":"Infectious mononucleosis; 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