{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:07:43Z","timestamp":1790647663211,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hepatosplenic candidiasis (HSC) used to be reported in patients with acute myeloid leukemia (AML) without antifungal prophylaxis. The aim was to describe the clinical features and outcomes of HSC over the last 13 years in a single French hematology center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients diagnosed with HSC between 2008 and 2020 were included in a single-center retrospective cohort study. Data were collected from patient charts, and HSC was classified according to the 2020 European Organisation for Research and Treatment of Cancer\/Mycoses Study Group definitions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sixty patients were included, with 18.3% proven, 3.3% probable, and 78.3% possible HSC according to the 2020 European Organization for Research and Treatment of Cancer Mycoses Study Group classification. Among them, 19 patients were treated for acute myeloid leukemia (AML), 21 for lymphomas, and 14 for acute lymphoblastic leukemia. HSC occurred in 13 patients after autologous stem cell transplantation for lymphoma. At HSC diagnosis, 13 patients were receiving antifungal prophylaxis. Candida colonization was present in 84.2%, with prior candidemia in 36.7% of cases. \u03b2-D-glucans was positive in 55.8%, and 45.8% of tissue biopsies were contributive. First-line antifungal therapy was azoles in 61.7%, and steroids were associated in 45% of cases. At 3 months of follow-up, partial response to antifungal therapy was 94.2%. At last follow-up (mean, 22.6 months), 41 patients (68.3%) presented a complete hematological remission and 22 patients were deceased, none because of HSC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The epidemiology of HSC has changed in the last decade, with fewer cases occurring in the AML setting. A better identification of patients at risk could lead to specific prophylaxis and improved diagnosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofac088","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T17:29:50Z","timestamp":1646674190000},"source":"Crossref","is-referenced-by-count":16,"title":["Hepatosplenic Candidiasis in Patients With Hematological Malignancies: A 13-Year Retrospective Cohort Study"],"prefix":"10.1093","volume":"9","author":[{"given":"In\u00e8s","family":"Boussen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Saint Louis and Lariboisi\u00e8re Hospitals, APHP, Paris, France"},{"name":"Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Lisan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, School of Medicine, University Paris Saclay, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Raffoux","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology, Saint Louis Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Di Blasi","sequence":"additional","affiliation":[{"name":"Department of Hemato-oncology, Saint Louis Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Boissel","sequence":"additional","affiliation":[{"name":"Department of Teenagers and Young Adult Hematology, Saint Louis Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Oksenhendler","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Saint Louis Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Ad\u00e8s","sequence":"additional","affiliation":[{"name":"Department of Senior Adult Hematology, Saint Louis Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali\u00e9nor","family":"Xhaard","sequence":"additional","affiliation":[{"name":"Department of Hematology - Transplantation, Saint Louis Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Bretagne","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris, France"},{"name":"Molecular Mycology Unit, Institut Pasteur, CNRS UMR2000, Paris, France"},{"name":"Department of Mycology, Saint Louis Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Alanio","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris, France"},{"name":"Molecular Mycology Unit, Institut Pasteur, CNRS UMR2000, Paris, France"},{"name":"Department of Mycology, Saint Louis Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Saint Louis and Lariboisi\u00e8re Hospitals, APHP, Paris, France"},{"name":"Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Denis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Saint Louis and Lariboisi\u00e8re Hospitals, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"2022032913363908300_CIT0001","doi-asserted-by":"crossref","first-page":"88","DOI":"10.7326\/0003-4819-108-1-88","article-title":"Hepatic candidiasis in cancer patients: the evolving picture of the syndrome.","volume":"108","author":"Thaler","year":"1988","journal-title":"Ann Intern Med"},{"key":"2022032913363908300_CIT0002","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0891-5520(05)70128-8","article-title":"Hepatosplenic candidiasis. 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