{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:20:40Z","timestamp":1773339640050,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32LM012410"],"award-info":[{"award-number":["5T32LM012410"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Case series without control groups suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in cognitive deficits and dementia in the postinfectious period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adult pneumonia patients with SARS-CoV-2 infection (index hospitalization) and age-, gender-, and race\/ethnicity-matched contemporary control pneumonia patients without SARS-CoV-2 infection were identified from 110 healthcare facilities in United States. The risk of new diagnosis of dementia following &amp;gt;30 days after the index hospitalization event without any previous history of dementia was identified using logistic regression analysis to adjust for potential confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 10\u00a0403 patients with pneumonia associated with SARS-CoV-2 infection, 312 patients (3% [95% confidence interval {CI}, 2.7%\u20133.4%]) developed new-onset dementia over a median period of 182 days (quartile 1\u2005=\u2005113 days, quartile 3\u2005=\u2005277 days). After adjustment for age, gender, race\/ethnicity, hypertension, diabetes mellitus, hyperlipidemia, nicotine dependence\/tobacco use, alcohol use\/abuse, atrial fibrillation, previous stroke, and congestive heart failure, the risk of new-onset dementia was significantly higher with pneumonia associated with SARS-CoV-2 infection compared with pneumonia unrelated to SARS-CoV-2 infection (odds ratio [OR], 1.3 [95% CI, 1.1\u20131.5]). The association remained significant after further adjustment for occurrence of stroke, septic shock, and intubation\/mechanical ventilation during index hospitalization (OR, 1.3 [95% CI, 1.1\u20131.5]).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Approximately 3% of patients with pneumonia associated with SARS-CoV-2 infection developed new-onset dementia, which was significantly higher than the rate seen with other pneumonias.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofac115","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T19:06:28Z","timestamp":1646679988000},"source":"Crossref","is-referenced-by-count":22,"title":["New-Onset Dementia Among Survivors of Pneumonia Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-540X","authenticated-orcid":false,"given":"Adnan I","family":"Qureshi","sequence":"first","affiliation":[{"name":"Zeenat Qureshi Stroke Institutes and Department of Neurology, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William I","family":"Baskett","sequence":"additional","affiliation":[{"name":"Institute for Data Science and Informatics, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Zeenat Qureshi Stroke Institutes and Department of Neurology, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Hasan","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Ren","family":"Shyu","sequence":"additional","affiliation":[{"name":"Institute for Data Science and Informatics, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Medicine, University of Missouri, Columbia, Missouri, USA"},{"name":"Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"2022032913364906800_CIT0001","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S2213-2600(21)00383-0","article-title":"Physical, cognitive, and mental health impacts of COVID-19 following hospitalisation (PHOSP-COVID): a UK multi-centre, prospective cohort study.","volume":"9","author":"Evans","year":"2021","journal-title":"Lancet Respir Med"},{"key":"2022032913364906800_CIT0002","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-021-03553-9","article-title":"High-dimensional characterization of post-acute sequelae of COVID-19.","volume":"594","author":"Al-Aly","year":"2021","journal-title":"Nature"},{"key":"2022032913364906800_CIT0003","doi-asserted-by":"crossref","first-page":"345","DOI":"10.14336\/AD.2021.0109","article-title":"SARS-CoV-2 emergency and long-term cognitive impairment in older people.","volume":"12","author":"Rizzo","year":"2021","journal-title":"Aging Dis"},{"key":"2022032913364906800_CIT0004","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s13365-021-00954-4","article-title":"Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients.","volume":"27","author":"Hellmuth","year":"2021","journal-title":"J Neurovirol"},{"key":"2022032913364906800_CIT0005","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/jnnp-2020-325173","article-title":"Pattern of cognitive deficits in severe COVID-19.","volume":"92","author":"Beaud","year":"2021","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2022032913364906800_CIT0006","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1016\/j.jinf.2020.08.029","article-title":"Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19.","volume":"81","author":"Garrigues","year":"2020","journal-title":"J Infect"},{"key":"2022032913364906800_CIT0007","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1164\/rccm.201904-0816CI","article-title":"Natural history of cognitive impairment in critical illness survivors. 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