{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:44:55Z","timestamp":1786790695475,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lemierre\u2019s syndrome (LS) is a rare and potentially fatal condition that predominantly affects young adults with oropharyngeal infection. Fusobacterium necrophorum is the usual etiology and classically causes internal jugular vein septic thrombophlebitis, frequently complicated by septic emboli to several organs (most classically to the lungs). Lemierre-like syndrome (LLS) describes the same constellation of symptoms and pathophysiology as Lemierre\u2019s syndrome; however, Fusobacterium spp. are not the cause, and the source of infection may be nonoropharyngeal. We present a case with an unusual etiology of LLS: a patient with untreated preseptal cellulitis and associated methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in the setting of injection drug use. Physical exam revealed tachypnea and rhonchi with severe periorbital and bilateral eyelid edema. Imaging demonstrated bilateral preseptal and orbital cellulitis with thrombosis of both internal jugular veins and bilateral pulmonary cavitary lesions consistent with septic pulmonary emboli. She was managed with anticoagulation and parenteral antibiotics. To our knowledge, this is the first case of LLS originating from preseptal cellulitis without evidence of preceding pharyngitis. While facial and orbital infections are rare etiologies of LLS, the potentially devastating sequelae of LLS warrant its inclusion in differential diagnoses.<\/jats:p>","DOI":"10.1093\/ofid\/ofac143","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T14:20:55Z","timestamp":1650291655000},"source":"Crossref","is-referenced-by-count":3,"title":["An Unusual Etiology of Lemierre-Like Syndrome: Preseptal Cellulitis due to Methicillin-Resistant <i>Staphylococcus aureus<\/i>"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2886-0232","authenticated-orcid":false,"given":"Noah","family":"Newman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amlak","family":"Bantikassegn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G","family":"West","sequence":"additional","affiliation":[{"name":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"James E","family":"Peacock","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"2022050514253933100_CIT0001","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0140-6736(00)57035-4","article-title":"On certain septic\u00e6mias due to anaerobic organisms.","volume":"227","author":"Lemierre","year":"1936","journal-title":"Lancet"},{"key":"2022050514253933100_CIT0002","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/lary.20542","article-title":"Lemierre\u2019s syndrome: a systematic review.","volume":"119","author":"Karkos","year":"2009","journal-title":"Laryngoscope"},{"key":"2022050514253933100_CIT0003","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/23744235.2019.1691255","article-title":"A Lemierre-like syndrome caused by Staphylococcus aureus: an emerging disease.","volume":"52","author":"Van Hoecke","year":"2020","journal-title":"Infect Dis"},{"key":"2022050514253933100_CIT0004","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2147\/IDR.S95050","article-title":"Lemierre\u2019s syndrome: current perspectives on diagnosis and management.","volume":"9","author":"Johannesen","year":"2016","journal-title":"Infect Drug 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Dis"},{"key":"2022050514253933100_CIT0008","volume-title":"Lemierre Syndrome","author":"Allen","year":"2021"},{"key":"2022050514253933100_CIT0009","doi-asserted-by":"crossref","first-page":"1089.e7","DOI":"10.1016\/j.cmi.2019.12.002","article-title":"Invasive infections with Fusobacterium necrophorum including Lemierre\u2019s syndrome: an 8-year Swedish nationwide retrospective study.","volume":"26","author":"Nygren","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"2022050514253933100_CIT0010","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jmii.2020.03.027","article-title":"Lemierre\u2019s syndrome: a forgotten and re-emerging infection.","volume":"53","author":"Lee","year":"2020","journal-title":"J Microbiol Immunol Infect"},{"key":"2022050514253933100_CIT0011","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/jama.2019.18211","article-title":"Periorbital and orbital cellulitis.","volume":"323","author":"Baiu","year":"2020","journal-title":"JAMA"},{"key":"2022050514253933100_CIT0012","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/00365540500372846","article-title":"Persistence in Staphylococcus aureus bacteremia: incidence, characteristics of patients and outcome.","volume":"38","author":"Khatib","year":"2006","journal-title":"Scand J Infect Dis"},{"key":"2022050514253933100_CIT0013","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s100720100073","article-title":"Lemierre\u2019s syndrome complicated by carotid thrombosis.","volume":"22","author":"Maalikjy","year":"2001","journal-title":"Neurol Sci"},{"key":"2022050514253933100_CIT0014","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3171\/ped.2007.106.1.53","article-title":"Lemierre syndrome complicated by cavernous sinus thrombosis, the development of subdural empyemas, and internal carotid artery narrowing without cerebral infarction: case 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Case 36-2014. An 18-year-old woman with fever, pharyngitis, and double vision.","volume":"371","author":"Olson","year":"2014","journal-title":"N Engl J Med"},{"key":"2022050514253933100_CIT0019","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000500560","article-title":"Lemierre\u2019s syndrome caused by Streptococcus anginosus presenting as postseptal cellulitis in a pediatric patient.","volume":"81","author":"Camacho-Cruz","year":"2019","journal-title":"J Otorhinolaryngol Relat Spec"},{"key":"2022050514253933100_CIT0020","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1186\/1752-1947-2-374","article-title":"Lemierre\u2019s syndrome due to community-acquired methicillin-resistant Staphylococcus aureus infection and presenting with orbital cellulitis: a case report.","volume":"2","author":"Kadhiravan","year":"2008","journal-title":"J Med Case Rep"},{"key":"2022050514253933100_CIT0021","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1865-1380-6-40","article-title":"Lemierre\u2019s syndrome.","volume":"6","author":"Eilbert","year":"2013","journal-title":"Int J Emerg Med"},{"key":"2022050514253933100_CIT0022","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S1473-3099(12)70089-0","article-title":"Lemierre\u2019s syndrome due to Fusobacterium necrophorum.","volume":"12","author":"Kuppalli","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"2022050514253933100_CIT0023","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1017\/S0022215113001035","article-title":"Methicillin-resistant Staphylococcus aureus bacteraemia associated with Lemierre\u2019s syndrome: case report and literature review.","volume":"127","author":"Kizhner","year":"2013","journal-title":"J Laryngol Otol"},{"key":"2022050514253933100_CIT0024","volume-title":"Cavernous Sinus Thrombosis","author":"Plewa","year":"2021"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofac143\/43391121\/ofac143.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/9\/5\/ofac143\/43516119\/ofac143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/9\/5\/ofac143\/43516119\/ofac143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T14:28:03Z","timestamp":1651760883000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofac143\/6569899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,18]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofac143","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5,1]]},"published":{"date-parts":[[2022,4,18]]},"article-number":"ofac143"}}