{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:51:37Z","timestamp":1770727897112,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AI143453"],"award-info":[{"award-number":["R01 AI143453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Antibody immunity has not been studied in organ transplant recipients (OTRs) with cryptococcosis. We determined serum antibody levels in OTRs: 23 cryptococcosis cases and 21 controls. Glucuronoxylomannan immunoglobulin M (IgM) and laminarin IgM were lower in cases than controls, were inversely associated with cryptococcosis status, and may hold promise as markers of cryptococcosis.<\/jats:p>","DOI":"10.1093\/ofid\/ofac211","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T12:41:19Z","timestamp":1650458479000},"source":"Crossref","is-referenced-by-count":4,"title":["<i>Cryptococcus neoformans\u2013<\/i>Specific and Non\u2013<i>Cryptococcus neoformans<\/i>\u2013Specific Antibody Profiles in Organ Transplant Recipients With and Without Cryptococcosis"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-6876","authenticated-orcid":false,"given":"Hyunah","family":"Yoon","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Nakouzi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center , Bronx, New York , USA"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G","family":"Pappas","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vagish S","family":"Hemmige","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liise anne","family":"Pirofski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center , Bronx, New York , USA"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"2022073009484700900_ofac211-B1","doi-asserted-by":"crossref","first-page":"e13543","DOI":"10.1111\/ctr.13543","article-title":"Cryptococcosis in solid organ transplantation: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","volume":"33","author":"Baddley","year":"2019","journal-title":"Clin Transplant"},{"key":"2022073009484700900_ofac211-B2","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1086\/651262","article-title":"Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET)","volume":"50","author":"Pappas","year":"2010","journal-title":"Clin Infect Dis"},{"key":"2022073009484700900_ofac211-B3","doi-asserted-by":"crossref","first-page":"ofy333","DOI":"10.1093\/ofid\/ofy333","article-title":"Antibody responses in HIV-infected patients with advanced immunosuppression and asymptomatic cryptococcal antigenemia","volume":"6","author":"Hlupeni","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"2022073009484700900_ofac211-B4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.vaccine.2008.11.030","article-title":"Anti-beta-glucan antibodies in healthy human subjects","volume":"27","author":"Chiani","year":"2009","journal-title":"Vaccine"},{"key":"2022073009484700900_ofac211-B5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/infdis\/jiy447","article-title":"Association between plasma antibody responses and risk for cryptococcus-associated immune reconstitution inflammatory syndrome","volume":"219","author":"Yoon","year":"2019","journal-title":"J Infect Dis"},{"key":"2022073009484700900_ofac211-B6","article-title":"Antibody and B cell subset perturbations in HIV-uninfected patients with cryptococcosis","volume":"5","author":"Rohatgi","year":"2017","journal-title":"Open Forum Infect Dis"},{"key":"2022073009484700900_ofac211-B7","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1128\/CVI.00139-06","article-title":"Antibody response to Cryptococcus neoformans capsular polysaccharide glucuronoxylomannan in patients after solid-organ transplantation","volume":"13","author":"Jalali","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"2022073009484700900_ofac211-B8","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1399-3062.2009.00407.x","article-title":"Mycophenolate mofetil: effects on cellular immune subsets, infectious complications, and antimicrobial activity","volume":"11","author":"Ritter","year":"2009","journal-title":"Transpl Infect Dis"},{"key":"2022073009484700900_ofac211-B9","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/cei.12604","article-title":"Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells","volume":"180","author":"De Bruyne","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"2022073009484700900_ofac211-B10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1128\/iai.56.1.7-12.1988","article-title":"Cyclosporin A inhibits the growth of Cryptococcus neoformans in a murine model","volume":"56","author":"Mody","year":"1988","journal-title":"Infect Immun"},{"key":"2022073009484700900_ofac211-B11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1128\/AAC.41.1.156","article-title":"The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein","volume":"41","author":"Odom","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"2022073009484700900_ofac211-B12","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1086\/511438","article-title":"Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality","volume":"195","author":"Singh","year":"2007","journal-title":"J Infect Dis"},{"key":"2022073009484700900_ofac211-B13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1365-2249.1995.tb05568.x","article-title":"Antibodies to the Cryptococcus neoformans capsular glucuronoxylomannan are ubiquitous in serum from HIV+ and HIV\u2212 individuals","volume":"99","author":"Deshaw","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"2022073009484700900_ofac211-B14","first-page":"1168","article-title":"Cryptococcus neoformans\u2013reactive and total immunoglobulin profiles of human immunodeficiency virus-infected and uninfected Ugandans","volume":"12","author":"Subramaniam","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"2022073009484700900_ofac211-B15","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1086\/315102","article-title":"Quantitative and qualitative differences in the serum antibody profiles of human immunodeficiency virus-infected persons with and without Cryptococcus neoformans meningitis","volume":"180","author":"Fleuridor","year":"1999","journal-title":"J Infect Dis"},{"key":"2022073009484700900_ofac211-B16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1086\/599318","article-title":"IgM(+) memory B cell expression predicts HIV-associated cryptococcosis status","volume":"200","author":"Subramaniam","year":"2009","journal-title":"J Infect Dis"},{"key":"2022073009484700900_ofac211-B17","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1128\/iai.64.9.3446-3450.1996","article-title":"Opsonization of Cryptococcus neoformans by human anticryptococcal glucuronoxylomannan antibodies","volume":"64","author":"Zhong","year":"1996","journal-title":"Infect Immun"},{"key":"2022073009484700900_ofac211-B18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1128\/IAI.72.1.196-208.2004","article-title":"Immunogenicity and efficacy of Cryptococcus neoformans capsular polysaccharide glucuronoxylomannan peptide mimotope-protein conjugates in human immunoglobulin transgenic mice","volume":"72","author":"Maitta","year":"2004","journal-title":"Infect Immun"},{"key":"2022073009484700900_ofac211-B19","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.4049\/jimmunol.166.2.1087","article-title":"A cryptococcal capsular polysaccharide mimotope prolongs the survival of mice with Cryptococcus neoformans infection","volume":"166","author":"Fleuridor","year":"2001","journal-title":"J Immunol"},{"key":"2022073009484700900_ofac211-B20","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1128\/IAI.00278-07","article-title":"An anti-beta-glucan monoclonal antibody inhibits growth and capsule formation of Cryptococcus neoformans in vitro and exerts therapeutic, anticryptococcal activity in vivo","volume":"75","author":"Rachini","year":"2007","journal-title":"Infect Immun"},{"key":"2022073009484700900_ofac211-B21","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1128\/IAI.68.12.7049-7060.2000","article-title":"Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth","volume":"68","author":"Rodrigues","year":"2000","journal-title":"Infect Immun"},{"key":"2022073009484700900_ofac211-B22","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00046-20","article-title":"Human IgM inhibits the formation of titan-like cells in Cryptococcus neoformans","volume":"88","author":"Trevijano-Contador","year":"2020","journal-title":"Infect Immun"},{"key":"2022073009484700900_ofac211-B23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/imr.12397","article-title":"Manipulation of the glycan-specific natural antibody repertoire for immunotherapy","volume":"270","author":"New","year":"2016","journal-title":"Immunol Rev"},{"key":"2022073009484700900_ofac211-B24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2217\/fmb.14.132","article-title":"Host immunity to Cryptococcus neoformans","volume":"10","author":"Rohatgi","year":"2015","journal-title":"Future Microbiol"},{"key":"2022073009484700900_ofac211-B25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1086\/314953","article-title":"Antibodies reactive with the cryptococcal capsular polysaccharide glucuronoxylomannan are present in sera from children with and without human immunodeficiency virus infection","volume":"180","author":"Abadi","year":"1999","journal-title":"J Infect Dis"},{"issue":"Suppl 7","key":"2022073009484700900_ofac211-B26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/imj.15590","article-title":"Consensus guidelines for the diagnosis and management of cryptococcosis and rare yeast infections in the haematology\/oncology setting, 2021","volume":"51","author":"Chang","year":"2021","journal-title":"Intern Med J"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofac211\/43402013\/ofac211.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/9\/7\/ofac211\/45028788\/ofac211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/9\/7\/ofac211\/45028788\/ofac211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T09:49:29Z","timestamp":1659174569000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofac211\/6571358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofac211","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,4,20]]},"article-number":"ofac211"}}