{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T02:27:41Z","timestamp":1772072861554,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cellulitis is a common disease in the elderly, and detecting etiologic organisms with blood cultures is difficult because of the low positive rate and occasional skin contamination. Therefore, routine blood cultures are not recommended for uncomplicated cellulitis. However, it is unclear whether blood culture collection for the diagnosis of cellulitis in elderly patients is useful.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This single hospital\u2013based observational study was performed between April 2012 and March 2015 in Okinawa, Japan. All enrolled patients were aged 15 years or older and admitted to the Division of Infectious Diseases with suspected cellulitis, erysipelas, and cutaneous abscess. Two routine sets of blood cultures were obtained.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two hundred and twenty-one patients were enrolled. The median age was 77 years. The proportion of bacteremia was 21.7% for all patients (48\/221), 8.5% (4\/47) for those &amp;lt;65 years, and 25.3% (44\/174) for those \u226565 years old (P\u2009=\u2009.013). The skin contamination rate was 0.9% (2\/221). The most common pathogen was Streptococcus dysgalactiae (62.5%). Gram-negative bacteremia not susceptible to cefazolin was detected in 8.3%. Cefazolin and ampicillin were the first- and second-most commonly used therapies. Anti\u2013methicillin-resistant Staphylococcus aureus therapy was required in 3.6% of patients. In addition to age and severe infection, shaking chills and white blood count \u226513\u2009000 cells\/\u00b5L were independent risk factors of bacteremia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Two routine sets of blood cultures are recommended for the precise diagnosis and appropriate treatment of cellulitis in elderly patients, especially in patients with shaking chills or leukocytosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofac317","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T17:30:50Z","timestamp":1656091850000},"source":"Crossref","is-referenced-by-count":9,"title":["High Yield of Blood Cultures in the Etiologic Diagnosis of Cellulitis, Erysipelas, and Cutaneous Abscess in Elderly Patients"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-3767","authenticated-orcid":false,"given":"Tomohiro","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Okinawa Chubu Hospital , Uruma, Okinawa , Japan"},{"name":"Division of General Internal Medicine and Infectious Diseases, Hiroshima Prefectural Hospital , Minami-ku, Hiroshima , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanefumi","family":"Tsuha","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Okinawa Chubu Hospital , Uruma, Okinawa , Japan"},{"name":"Division of General Internal Medicine and Infectious Diseases, Sakibana Hospital , Izumi, Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichi","family":"Shiiki","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Okinawa Chubu Hospital , Uruma, Okinawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Narita","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Okinawa Chubu Hospital , Uruma, Okinawa , Japan"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, Okinawa Nanbu Medical Center and Children's Medical Center , Shimajiri-gun, Okinawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Teruya","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Okinawa Chubu Hospital , Uruma, Okinawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyuki","family":"Hachiman","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Okinawa Chubu Hospital , Uruma, Okinawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyasu","family":"Kogachi","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Okinawa Chubu Hospital , Uruma, Okinawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"2022072511184962800_ofac317-B1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1001\/jama.2016.8825","article-title":"Cellulitis: a review","volume":"316","author":"Raff","year":"2016","journal-title":"JAMA"},{"key":"2022072511184962800_ofac317-B2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1086\/656431","article-title":"Skin and soft-tissue infections requiring hospitalization at an academic medical center: opportunities for antimicrobial stewardship","volume":"51","author":"Jenkins","year":"2010","journal-title":"Clin Infect Dis"},{"key":"2022072511184962800_ofac317-B3","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1001\/jama.2012.8262","article-title":"Does this adult patient with suspected bacteremia require blood cultures?","volume":"308","author":"Coburn","year":"2012","journal-title":"JAMA"},{"key":"2022072511184962800_ofac317-B4","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/cid\/ciaa039","article-title":"Does this patient need blood cultures? 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