{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:30:08Z","timestamp":1791876608216,"version":"4.3.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Prison-based hepatitis C treatment is safe and effective; however, many individuals are released untreated due to time or resource constraints. On community re-entry, individuals face a number of immediate competing priorities, and in this context, linkage to hepatitis C care is low. Interventions targeted at improving healthcare continuity after prison release have yielded positive outcomes for other health diagnoses; however, data regarding hepatitis C transitional care are limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective randomized controlled trial comparing a hepatitis C care navigator intervention with standard of care for individuals released from prison with untreated hepatitis C infection. The primary outcome was prescription of hepatitis C direct-acting antivirals (DAA) within 6 months of release.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-six participants were randomized. The median age was 36 years and 59% were male. Ninety percent (n\u2009=\u200936 of 40) had injected drugs within 6 months before incarceration. Twenty-two were randomized to care navigation and 24 were randomized to standard of care. Individuals randomized to the intervention were more likely to commence hepatitis C DAAs within 6 months of release (73%, n\u2009=\u200916 of 22 vs 33% n\u2009=\u20098 of 24, P\u2009&amp;lt;\u2009.01), and the median time between re-entry and DAA prescription was significantly shorter (21\u2005days [interquartile range {IQR}, 11\u201342] vs 82\u2005days [IQR, 44\u201399], P\u2009=\u2009.049).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Care navigation increased hepatitis C treatment uptake among untreated individuals released from prison. Public policy should support similar models of care to promote treatment in this high-risk population. Such an approach will help achieve hepatitis C elimination as a public health threat.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofac350","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T14:42:39Z","timestamp":1659019359000},"source":"Crossref","is-referenced-by-count":24,"title":["Care Navigation Increases Initiation of Hepatitis C Treatment After Release From Prison in a Prospective Randomized Controlled Trial: The C-LINK Study"],"prefix":"10.1093","volume":"9","author":[{"given":"Timothy","family":"Papaluca","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"},{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Craigie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"},{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"},{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Pappas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife","family":"Waldron","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Stoove","sequence":"additional","affiliation":[{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"},{"name":"Department of Epidemiology and Preventative Medicine, Monash University , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Doyle","sequence":"additional","affiliation":[{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"},{"name":"Department of Epidemiology and Preventative Medicine, Monash University , Melbourne, Victoria , Australia"},{"name":"Department of Infectious Diseases, The Alfred and Monash University , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Hellard","sequence":"additional","affiliation":[{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"},{"name":"Department of Epidemiology and Preventative Medicine, Monash University , Melbourne, Victoria , Australia"},{"name":"Department of Infectious Diseases, The Alfred and Monash University , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinta","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"},{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-1468","authenticated-orcid":false,"given":"Michael","family":"MacIsaac","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"},{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Desmond","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"},{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Iser","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"},{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent's Hospital , Melbourne, Victoria , Australia"},{"name":"Burnet Institute, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"2022080617300080000_ofac350-B1","article-title":"Combating hepatitis B and C to reach elimination by 2030: advocacy brief","author":"World Health Organization"},{"key":"2022080617300080000_ofac350-B2","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1136\/gutjnl-2016-311504","article-title":"Treatment scale-up to achieve global HCV incidence and mortality elimination targets: a cost-effectiveness model","volume":"66","author":"Scott","year":"2017","journal-title":"Gut"},{"key":"2022080617300080000_ofac350-B3","doi-asserted-by":"crossref","first-page":"e1192","DOI":"10.1016\/S2214-109X(17)30375-3","article-title":"Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: a multistage systematic 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Supported housing for prisoners returning to the community: A review of the literature. Research Report no. 7. Canberra: Australian Institute of Criminology. 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