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We present the case of a 19-year-old man treated with adalimumab for Crohn\u2019s disease who presented with disseminated miliary tuberculosis. His treatment course was complicated by central nervous system TB-IRIS following cessation of his immunosuppression. We review the presentation and differential diagnosis of TB-IRIS, as well as risk factors for developing IRIS and the treatment of IRIS in this population.<\/jats:p>","DOI":"10.1093\/ofid\/ofac367","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T08:15:48Z","timestamp":1658477748000},"source":"Crossref","is-referenced-by-count":3,"title":["CNS TB-IRIS Following Cessation of Adalimumab in an Adolescent With Crohn\u2019s Disease"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-865X","authenticated-orcid":false,"given":"Elizabeth","family":"Christian","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Boston Children\u2019s Hospital , Boston, Massachusetts , USA"},{"name":"Division of Infectious Disease, Beth Israel Deaconess Medical Center , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Johnston","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Boston Children\u2019s Hospital , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"2022080617294994600_ofac367-B1","article-title":"Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV","author":"Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV"},{"key":"2022080617294994600_ofac367-B2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jctube.2016.03.002","article-title":"Tuberculosis-immune reconstitution inflammatory syndrome","volume":"3","author":"Lanzafame","year":"2016","journal-title":"J Clin Tuberc Other Mycobact 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