{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:01:36Z","timestamp":1773028896045,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Institute for Allergy and Infectious Diseases","award":["T32-AI055435 to H. L. Z."],"award-info":[{"award-number":["T32-AI055435 to H. L. Z."]}]},{"name":"National Institute for Allergy and Infectious Diseases","award":["K01-AI137317 to J. A. A."],"award-info":[{"award-number":["K01-AI137317 to J. A. A."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Reported \u03b2-lactam allergies (BLAs) are common and frequently inaccurate, but there are limited data on the clinical implications of BLA among solid organ transplant (SOT) recipients. We examined the impact of BLA on clinical outcomes and antibiotic use among SOT recipients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cohort study included adult patients undergoing single-organ heart, kidney, liver, lung, or pancreas transplant at a United States academic medical center from 1 April 2017 to 31 December 2020. Demographic and clinical data were collected from the electronic health record. Multivariate median regression was performed to evaluate the association between BLA and days alive and out of the hospital in the first 180 days posttransplant (DAOH180). Multivariate logistic regression was performed to evaluate the association between BLA and antibiotic use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 1700 SOT recipients, 285 (16.8%) had a BLA at the time of transplant. BLA was not associated with DAOH180 (adjusted median difference, \u20130.8 days [95% confidence interval {CI}, \u20132.7 to 1.2]; P\u2009=\u2009.43). Patients with BLA were more likely to receive intravenous vancomycin (adjusted odds ratio [aOR], 1.8 [95% CI, 1.3\u20132.6]; P\u2009&amp;lt;\u2009.001), clindamycin (aOR, 9.9 [95% CI, 5.1\u201318.9]; P\u2009&amp;lt;\u2009.001), aztreonam (aOR, 19.6 [95% CI, 5.9\u201364.4]; P\u2009&amp;lt;\u2009.001), fluoroquinolones (aOR, 3.8 [95% CI, 2.8\u20135.0]; P\u2009&amp;lt;\u2009.001), or aminoglycosides (aOR, 3.9 [95% CI, 2.5\u20136.2]; P\u2009&amp;lt;\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>BLA was associated with use of \u03b2-lactam alternative antibiotics but not DAOH180 among SOT recipients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofac384","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T16:38:56Z","timestamp":1659112736000},"source":"Crossref","is-referenced-by-count":6,"title":["The Impact of Reported \u03b2-Lactam Allergy on Clinical Outcomes and Antibiotic Use Among Solid Organ Transplant Recipients"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8978-1832","authenticated-orcid":false,"given":"Helen L","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"},{"name":"Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A","family":"Anesi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"},{"name":"Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"},{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith W","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh","family":"Cressman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren B","family":"Bilker","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"},{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebbing","family":"Lautenbach","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"},{"name":"Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"},{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"2022081609342063400_ofac384-B1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s11882-014-0476-y","article-title":"Penicillin and beta-lactam allergy: epidemiology and diagnosis","volume":"14","author":"Macy","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"2022081609342063400_ofac384-B2","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/cid\/ciw462","article-title":"Impact of reported beta-lactam allergy on inpatient outcomes: a multicenter prospective cohort study","volume":"63","author":"MacFadden","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2022081609342063400_ofac384-B3","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1001\/archinte.160.18.2819","article-title":"The incidence of antimicrobial allergies in hospitalized patients: implications regarding prescribing 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