{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:21:32Z","timestamp":1791321692812,"version":"4.3.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate clinical outcomes in the published literature on medical and surgical management of diabetic foot osteomyelitis (DFO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PubMed and Google Scholar search of articles relating to DFO was performed over the dates of January 1931 to January 2020. Articles that involved Charcot arthropathy, case reports, small case series, review articles, commentaries, nonhuman studies, and non-English articles were excluded. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool was used to rate the bias of each study. A meta-analysis was performed using random-effects and inverse variance methods. The search yielded 1192 articles. After review and the removal of articles that did not meet inclusion criteria, 28 articles remained. Eighteen articles were related to the medical management of DFO and 13 articles were related to surgical management. Three articles looked at a combination of medical and surgical management and were included in both groups. Heterogeneity was evaluated using Cochran Q, I2, \u03c42, and \u03c4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average success rate was 68.2% (range, 17.0%\u201397.3%) for medical treatment and 85.7% (range, 65.0%\u201398.8%) for surgical and medical treatment. There were significant inconsistencies in accounting for peripheral arterial disease and peripheral neuropathy. There was significant heterogeneity in outcomes between studies. However, there was a high rate of successful treatment and a wide range between patients with medical treatment and combined surgical and medical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Additional properly designed prospective studies with gold-standard references for diagnosing osteomyelitis are needed to help determine whether medical management of DFO can be successful without surgical intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofac407","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T10:08:10Z","timestamp":1660039690000},"source":"Crossref","is-referenced-by-count":37,"title":["Meta-Analysis: Outcomes of Surgical and Medical Management of Diabetic Foot Osteomyelitis"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2688-066X","authenticated-orcid":false,"given":"David H","family":"Truong","sequence":"first","affiliation":[{"name":"Surgical Service, Podiatry Section, Veterans Affairs North Texas Health Care System , Dallas, Texas , USA"},{"name":"Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center , Dallas, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Bedimo","sequence":"additional","affiliation":[{"name":"Medical Service, Infectious Disease Section, Veterans Affairs North Texas Health Care System , Dallas, Texas , USA"},{"name":"Department of Infectious Disease, University of Texas Southwestern Medical Center , Dallas, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Malone","sequence":"additional","affiliation":[{"name":"Infectious Disease and Microbiology, School of Medicine, Western Sydney University , Campbelltown , Australia"},{"name":"South West Sydney Limb Preservation and Wound Research Academic Unit, South Western Sydney Local Health District , Sydney , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dane K","family":"Wukich","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center , Dallas, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan K","family":"Oz","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Texas Southwestern Medical Center , Dallas, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L","family":"Killeen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University of Texas Southwestern Medical Center , Dallas, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A","family":"Lavery","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center , Dallas, Texas , USA"},{"name":"Department of Plastic Surgery, University of Texas Southwestern Medical Center , Dallas, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"2022092702280362800_ofac407-B1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1464-5491.2011.03528.x","article-title":"Does osteomyelitis in the feet of patients with diabetes really recur after surgical treatment? Natural history of a surgical series","volume":"29","author":"Arag\u00f3n-S\u00e1nchez","year":"2012","journal-title":"Diabet Med"},{"key":"2022092702280362800_ofac407-B2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1053\/j.jfas.2017.01.025","article-title":"Nonsurgical treatment of osteomyelitis of the hallux sesamoids: a case series and literature review","volume":"56","author":"Mauler","year":"2017","journal-title":"J Foot Ankle Surg"},{"key":"2022092702280362800_ofac407-B3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2337\/dc14-1514","article-title":"Six-week versus twelve-week antibiotic therapy for nonsurgically treated diabetic foot osteomyelitis: a multicenter open-label controlled randomized study","volume":"38","author":"Tone","year":"2015","journal-title":"Diabetes Care"},{"key":"2022092702280362800_ofac407-B4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0002-9343(03)00231-6","article-title":"Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy","volume":"114","author":"Tice","year":"2003","journal-title":"Am J Med"},{"key":"2022092702280362800_ofac407-B5","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/jac\/48.6.927","article-title":"Rifampicin-ofloxacin oral regimen for the treatment of mild to moderate diabetic foot osteomyelitis","volume":"48","author":"Senneville","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"2022092702280362800_ofac407-B6","first-page":"31","article-title":"Conservative management of diabetic foot ulcers complicated by osteomyelitis","volume":"14","author":"Yadlapalli","year":"2002","journal-title":"Wounds"},{"key":"2022092702280362800_ofac407-B7","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0002-9343(89)90476-2","article-title":"Therapy of lower extremity infections with ciprofloxacin in patients with diabetes mellitus, peripheral vascular disease, or both","volume":"86","author":"Peterson","year":"1989","journal-title":"Am J Med"},{"key":"2022092702280362800_ofac407-B8","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0002-9343(87)90894-1","article-title":"Osteomyelitis in the feet of diabetic patients","volume":"83","author":"Bamberger","year":"1987","journal-title":"Am J Med"},{"key":"2022092702280362800_ofac407-B9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/archinte.159.8.851","article-title":"Outcome of diabetic foot infections treated conservatively","volume":"159","author":"Pittet","year":"1999","journal-title":"Arch Intern Med"},{"key":"2022092702280362800_ofac407-B10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3109\/00365548.2013.765589","article-title":"The implications of the presence of osteomyelitis on outcomes of infected diabetic foot wounds","volume":"45","author":"Mutluoglu","year":"2013","journal-title":"Scand J Infect Dis"},{"key":"2022092702280362800_ofac407-B11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2337\/dc13-1526","article-title":"Antibiotics versus conservative surgery for treating diabetic foot osteomyelitis: a randomized trial","volume":"37","author":"L\u00e1zaro-Mart\u00ednez","year":"2014","journal-title":"Diabetes Care"},{"key":"2022092702280362800_ofac407-B12","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/j.diabres.2013.06.010","article-title":"Conservative management of diabetic foot osteomyelitis","volume":"101","author":"Acharya","year":"2013","journal-title":"Diabetes Res Clin Pract"},{"key":"2022092702280362800_ofac407-B13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2337\/dc07-1744","article-title":"Outcome of diabetic foot osteomyelitis treated nonsurgically","volume":"31","author":"Senneville","year":"2008","journal-title":"Diabetes Care"},{"key":"2022092702280362800_ofac407-B14","first-page":"28","article-title":"Antibiotherapy with and without bone debridement in diabetic foot osteomyelitis: a retrospective cohort study","volume":"30","author":"Ulcay","year":"2014","journal-title":"Pak J Med Sci"},{"key":"2022092702280362800_ofac407-B15","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1464-5491.2009.02828.x","article-title":"Conservative management of diabetic forefoot ulceration complicated by underlying osteomyelitis: the benefits of magnetic resonance imaging","volume":"26","author":"Valabhji","year":"2009","journal-title":"Diabet Med"},{"key":"2022092702280362800_ofac407-B16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/(SICI)1096-9136(199706)14:6<487::AID-DIA373>3.0.CO;2-Q","article-title":"Conservative management of osteomyelitis in the feet of diabetic patients","volume":"14","author":"Venkatesan","year":"1997","journal-title":"Diabet Med"},{"key":"2022092702280362800_ofac407-B17","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1177\/107110070602701003","article-title":"Oral antimicrobial therapy for diabetic foot osteomyelitis","volume":"27","author":"Embil","year":"2006","journal-title":"Foot Ankle Int"},{"key":"2022092702280362800_ofac407-B18","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s00125-008-0976-1","article-title":"Primarily non-surgical management of osteomyelitis of the foot in diabetes","volume":"51","author":"Game","year":"2008","journal-title":"Diabetologia"},{"key":"2022092702280362800_ofac407-B19","doi-asserted-by":"crossref","first-page":"1264699","DOI":"10.1080\/2000625X.2017.1264699","article-title":"Partial calcanectomy and Ilizarov external fixation may reduce amputation need in severe diabetic calcaneal ulcers","volume":"8","author":"Akkurt","year":"2017","journal-title":"Diabet Foot Ankle"},{"key":"2022092702280362800_ofac407-B20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/01.ASW.0000407647.12832.6c","article-title":"Managing lower-extremity osteomyelitis locally with surgical debridement and synthetic calcium sulfate antibiotic tablets","volume":"24","author":"Gauland","year":"2011","journal-title":"Adv Skin Wound Care"},{"key":"2022092702280362800_ofac407-B21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1053\/j.jfas.2012.05.015","article-title":"Feasibility and effectiveness of internal pedal amputation of phalanx or metatarsal head in diabetic patients with forefoot osteomyelitis","volume":"51","author":"Faglia","year":"2012","journal-title":"J Foot Ankle Surg"},{"key":"2022092702280362800_ofac407-B22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.foot.2019.01.005","article-title":"Adjuvant antibiotic loaded biocomposite in the management of diabetic foot osteomyelitis\u2014a multicentre study","volume":"39","author":"Niazi","year":"2019","journal-title":"Foot"},{"key":"2022092702280362800_ofac407-B23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7547\/1020273","article-title":"Successful limb-sparing treatment strategy for diabetic foot osteomyelitis","volume":"102","author":"Beieler","year":"2012","journal-title":"J Am Podiatr Med Assoc"},{"key":"2022092702280362800_ofac407-B24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/1534734614559931","article-title":"Staphylococcus aureus\u2013related diabetic osteomyelitis: medical or surgical management? A French and Spanish retrospective cohort","volume":"14","author":"Lesens","year":"2015","journal-title":"Int J Low Extrem Wounds"},{"key":"2022092702280362800_ofac407-B25","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1464-5491.2009.02714.x","article-title":"Are diabetic foot ulcers complicated by MRSA osteomyelitis associated with worse prognosis? Outcome of a surgical series","volume":"26","author":"Arag\u00f3n-S\u00e1nchez","year":"2009","journal-title":"Diabet Med"},{"key":"2022092702280362800_ofac407-B26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/1534734611426364","article-title":"Surgical treatment of limb- and life-threatening infections in the feet of patients with diabetes and at least one palpable pedal pulse: successes and lessons learnt","volume":"10","author":"Arag\u00f3n-S\u00e1nchez","year":"2011","journal-title":"Int J Low Extrem Wounds"},{"key":"2022092702280362800_ofac407-B27","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/01.sla.0000164172.28918.3f","article-title":"Osteomyelitis of the foot and toe in adults is a surgical disease","volume":"241","author":"Henke","year":"2005","journal-title":"Ann Surg"},{"key":"2022092702280362800_ofac407-B28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1053\/j.jfas.2010.12.009","article-title":"The effect of residual osteomyelitis at the resection margin in patients with surgically treated diabetic foot infection","volume":"50","author":"Kowalski","year":"2011","journal-title":"J Foot Ankle Surg"},{"key":"2022092702280362800_ofac407-B29","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1007\/s00125-008-1131-8","article-title":"Outcome of surgical treatment of diabetic foot osteomyelitis: a series of 185 patients with histopathological confirmation of bone involvement","volume":"51","author":"Arag\u00f3n-S\u00e1nchez","year":"2008","journal-title":"Diabetologia"},{"key":"2022092702280362800_ofac407-B30","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.2337\/diacare.19.11.1257","article-title":"Treatment of osteomyelitis in the diabetic foot. Contribution of conservative surgery","volume":"19","author":"Ha Van","year":"1996","journal-title":"Diabetes Care"},{"key":"2022092702280362800_ofac407-B31","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1093\/cid\/cis346","article-title":"2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections","volume":"54","author":"Lipsky","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"Suppl 1","key":"2022092702280362800_ofac407-B32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/dmrr.2699","article-title":"IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes","volume":"32","author":"Lipsky","year":"2016","journal-title":"Diabetes Metab Res Rev"},{"issue":"Suppl 1","key":"2022092702280362800_ofac407-B33","doi-asserted-by":"crossref","first-page":"e3280","DOI":"10.1002\/dmrr.3280","article-title":"Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)","volume":"36","author":"Lipsky","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"issue":"Suppl 1","key":"2022092702280362800_ofac407-B34","doi-asserted-by":"crossref","first-page":"e3281","DOI":"10.1002\/dmrr.3281","article-title":"Diagnosis of infection in the foot in diabetes: a systematic review","volume":"36","author":"Senneville","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"issue":"Suppl 1","key":"2022092702280362800_ofac407-B35","doi-asserted-by":"crossref","first-page":"e3282","DOI":"10.1002\/dmrr.3282","article-title":"Interventions in the management of infection in the foot in diabetes: a systematic review","volume":"36","author":"Peters","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"key":"2022092702280362800_ofac407-B36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/095952876504800105","article-title":"Remarks upon osteo-myelitis consequent on gunshot wounds of the upper and lower extremities, and especially upon the treatment of stumps affected with osteomyelitis after amputation necessitated by such injuries","volume":"48","author":"Longmore","year":"1865","journal-title":"Med Chir Trans"},{"key":"2022092702280362800_ofac407-B37","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.diabres.2016.06.003","article-title":"Prevalence and comorbidities of double diabetes","volume":"119","author":"Merger","year":"2016","journal-title":"Diabetes Res Clin Pract"},{"key":"2022092702280362800_ofac407-B38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jcjd.2016.06.006","article-title":"The relationship between diabetes care quality and diabetes-related hospitalizations and the modifying role of comorbidity","volume":"41","author":"Petrosyan","year":"2017","journal-title":"Can J Diabetes"},{"key":"2022092702280362800_ofac407-B39","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1177\/1708538116673015","article-title":"Wound healing of critical limb ischemia with tissue loss in patients on hemodialysis","volume":"25","author":"Honda","year":"2017","journal-title":"Vascular"},{"key":"2022092702280362800_ofac407-B40","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jdiacomp.2015.02.009","article-title":"Congestive heart failure presence predicts delayed healing of foot ulcers in diabetes: an audit from a multidisciplinary high-risk foot clinic","volume":"29","author":"Rhou","year":"2015","journal-title":"J Diabetes Complicat"},{"key":"2022092702280362800_ofac407-B41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.diabres.2008.11.030","article-title":"Risk factors for developing osteomyelitis in patients with diabetic foot wounds","volume":"83","author":"Lavery","year":"2009","journal-title":"Diabetes Res Clin Pract"},{"key":"2022092702280362800_ofac407-B42","doi-asserted-by":"crossref","first-page":"e0124446","DOI":"10.1371\/journal.pone.0124446","article-title":"Diabetic foot complications and their risk factors from a large retrospective cohort study","volume":"10","author":"Al-Rubeaan","year":"2015","journal-title":"PLoS One"},{"key":"2022092702280362800_ofac407-B43","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/iwj.13055","article-title":"Complications associated with the approach to metatarsal head resection in diabetic foot osteomyelitis","volume":"16","author":"Tard\u00e1guila-Garc\u00eda","year":"2019","journal-title":"Int Wound J"},{"key":"2022092702280362800_ofac407-B44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1534734617728642","article-title":"The relationship between osteomyelitis complication and drug-resistant infection risk in diabetic foot ulcer: a meta-analysis","volume":"16","author":"Chen","year":"2017","journal-title":"Int J Low Extrem Wounds"},{"key":"2022092702280362800_ofac407-B45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.diabres.2017.06.002","article-title":"Complications during the treatment of diabetic foot osteomyelitis","volume":"135","author":"van Asten","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"2022092702280362800_ofac407-B46","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"key":"2022092702280362800_ofac407-B47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jrsm.1260","article-title":"Introduction, comparison and validation of meta-essentials: a free and simple tool for meta-analysis","volume":"8","author":"Suurmond","year":"2017","journal-title":"Res Synth Methods"},{"key":"2022092702280362800_ofac407-B48","volume-title":"User manual for meta-essentials: workbooks for meta-analysis (version 1.4)","author":"VanRhee","year":"2015"},{"key":"2022092702280362800_ofac407-B49","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analysis","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"2022092702280362800_ofac407-B50","first-page":"162","article-title":"Meta-analysis fixed effect vs random effects","author":"Borenstein","year":"2007"},{"key":"2022092702280362800_ofac407-B51","volume-title":"How to interpret results of meta-analysis (version 1.4)","author":"Hak","year":"2018"},{"key":"2022092702280362800_ofac407-B52","doi-asserted-by":"crossref","DOI":"10.7547\/20-147","article-title":"Are surrogate markers for diabetic foot osteomyelitis remission reliable?","volume":"111","author":"Crisologo","year":"2021","journal-title":"J Am Podiatr Med Assoc"},{"key":"2022092702280362800_ofac407-B53","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.idc.2017.01.004","article-title":"Radiologic approach to musculoskeletal infections","volume":"31","author":"Simpfendorfer","year":"2017","journal-title":"Infect Dis Clin North Am"},{"key":"2022092702280362800_ofac407-B54","doi-asserted-by":"crossref","first-page":"e54760","DOI":"10.1371\/journal.pone.0054760","article-title":"A human model of small fiber neuropathy to study wound healing","volume":"8","author":"Illigens","year":"2013","journal-title":"PLoS One"},{"key":"2022092702280362800_ofac407-B55","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.burns.2016.09.016","article-title":"Effects of small-fiber neuropathy induced by resiniferatoxin on skin healing and axonal regrowth after burn","volume":"43","author":"Laverdet","year":"2017","journal-title":"Burns"},{"key":"2022092702280362800_ofac407-B56","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/jid.2011.176","article-title":"Hemoglobin A1c predicts healing rate in diabetic wounds","volume":"131","author":"Christman","year":"2011","journal-title":"J Invest Dermatol"},{"key":"2022092702280362800_ofac407-B57","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/iwj.12622","article-title":"Vascular assessment of wound healing: a clinical review","volume":"14","author":"Li","year":"2017","journal-title":"Int Wound J"},{"key":"2022092702280362800_ofac407-B58","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.2337\/diacare.18.11.1460","article-title":"Increased foot pressures after great toe amputation in diabetes","volume":"18","author":"Lavery","year":"1995","journal-title":"Diabetes Care"},{"key":"2022092702280362800_ofac407-B59","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S1067-2516(97)80116-0","article-title":"The natural history of great toe amputations","volume":"36","author":"Murdoch","year":"1997","journal-title":"J Foot Ankle Surg"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofac407\/45295579\/ofac407.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/9\/9\/ofac407\/46041824\/ofac407.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/9\/9\/ofac407\/46041824\/ofac407.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T21:40:33Z","timestamp":1727732433000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofac407\/6658949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,9]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofac407","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2022,8,9]]},"article-number":"ofac407"}}