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Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options.<\/jats:p>","DOI":"10.1093\/ofid\/ofac472","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T04:14:20Z","timestamp":1662956060000},"source":"Crossref","is-referenced-by-count":2,"title":["Disseminated <i>Mycoplasma Orale<\/i> Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-7522","authenticated-orcid":false,"given":"Arthur H","family":"Totten","sequence":"first","affiliation":[{"name":"Clinical Center, National Institutes of Health , Bethesda, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulbu","family":"Uzel","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , 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