{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:05:07Z","timestamp":1788570307166,"version":"build-2803163510"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Pediatric Clinical Research Center Foundation of Sichuan Province, China","award":["2017-46-4"],"award-info":[{"award-number":["2017-46-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Infants are more likely to develop severe pertussis. We report a malignant pertussis case in a 2-month-old boy with respiratory failure, severe pneumonia, septic shock, and encephalopathy. Bordetella pertussis was detected from nasopharyngeal secretions by polymerase chain reaction, as well as both blood and cerebrospinal fluid samples via metagenomics next-generation sequencing.<\/jats:p>","DOI":"10.1093\/ofid\/ofac478","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T20:50:13Z","timestamp":1663793413000},"source":"Crossref","is-referenced-by-count":13,"title":["Invasive <i>Bordetella pertussis<\/i> Infection in Infants: A Case Report"],"prefix":"10.1093","volume":"9","author":[{"given":"Yang","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Infection, West China Second Hospital affiliated with Sichuan University , Chengdu , China"},{"name":"NHC Key Laboratory of Chronobiology, Sichuan University , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-ran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infection, West China Second Hospital affiliated with Sichuan University , Chengdu , China"},{"name":"NHC Key Laboratory of Chronobiology, Sichuan University , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infection, West China Second Hospital affiliated with Sichuan University , Chengdu , China"},{"name":"NHC Key Laboratory of Chronobiology, Sichuan University , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-hong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Infection, West China Second Hospital affiliated with Sichuan University , Chengdu , China"},{"name":"NHC Key Laboratory of Chronobiology, Sichuan University , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Infection, West China Second Hospital affiliated with Sichuan University , Chengdu , China"},{"name":"NHC Key Laboratory of Chronobiology, Sichuan University , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-min","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Infection, West China Second Hospital affiliated with Sichuan University , Chengdu , China"},{"name":"NHC Key Laboratory of Chronobiology, Sichuan University , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"2022100812104205000_ofac478-B1","doi-asserted-by":"crossref","first-page":"D36","DOI":"10.1093\/nar\/gks1195","article-title":"GenBank","volume":"41","author":"Benson","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2022100812104205000_ofac478-B2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1586\/14760584.2014.935766","article-title":"Pathogenesis and histopathology of pertussis: implications for immunization","volume":"13","author":"Cherry","year":"2014","journal-title":"Expert Rev Vaccines"},{"key":"2022100812104205000_ofac478-B3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrmicro3235","article-title":"Bordetella pertussis pathogenesis: current and future challenges","volume":"12","author":"Melvin","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"2022100812104205000_ofac478-B4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3390\/toxins11070373","article-title":"Association of pertussis toxin with severe pertussis disease","volume":"11","author":"Scanlon","year":"2019","journal-title":"Toxins (Basel)"},{"key":"2022100812104205000_ofac478-B5","doi-asserted-by":"crossref","first-page":"e00355","DOI":"10.1128\/IAI.00355-17","article-title":"Fatal pertussis in the neonatal mouse model is associated with pertussis toxin-mediated pathology beyond the 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