{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:34:41Z","timestamp":1789058081612,"version":"build-2803163510"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Outbreaks of healthcare-associated mucormycosis (HCM), a life-threatening fungal infection, have been attributed to multiple sources, including contaminated healthcare linens. In 2020, staff at Hospital A in Arkansas alerted public health officials of a potential HCM outbreak.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We collected data on patients at Hospital A who had invasive mucormycosis during January 2017\u2013June 2021 and calculated annual incidence of HCM (defined as mucormycosis diagnosed within \u22657 days after hospital admission). We performed targeted environmental assessments, including linen sampling at the hospital, to identify potential sources of infection.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n During the outbreak period (June 2019\u2013June 2021), 16 patients had HCM; clinical features were similar between HCM patients and non-HCM patients. Hospital-wide HCM incidence (per 100 000 patient-days) increased from 0 in 2018 to 3 in 2019 and 6 in 2020. For the 16 HCM patients, the most common underlying medical conditions were hematologic malignancy (56%) and recent traumatic injury (38%); 38% of HCM patients died in-hospital. Healthcare-associated mucormycosis cases were not epidemiologically linked by common procedures, products, units, or rooms. At Hospital A and its contracted offsite laundry provider, suboptimal handling of laundered linens and inadequate environmental controls to prevent mucormycete contamination were observed. We detected Rhizopus on 9 (9%) of 98 linens sampled at the hospital, including on linens that had just arrived from the laundry facility.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We describe the largest, single-center, HCM outbreak reported to date. Our findings underscore the importance of hospital-based monitoring for HCM and increased attention to the safe handling of laundered linens.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ofid\/ofac510","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T04:51:13Z","timestamp":1665982273000},"source":"Crossref","is-referenced-by-count":9,"title":["Investigation of a Prolonged and Large Outbreak of Healthcare-Associated Mucormycosis Cases in an Acute Care Hospital\u2014Arkansas, June 2019\u2013May 2021"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-866X","authenticated-orcid":false,"given":"Alexander","family":"Jordan","sequence":"first","affiliation":[{"name":"Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison 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